The aim of this project is to set up a cross-sectional cohort study (France, Germany, The Netherlands, Poland, Spain, Switzerland, Italy, United Kingdom and Portugal) to assess the implementation of EACS guidelines for HDV-testing among PLWH with positive HbsAg and thereby evaluate the prevalence of HDV infection among HIV/HBV-coinfected in 2023, as well as corresponding risk factors. In addition to the testing itself, this study will also set up a cohort and databasee for future HDV studies among PLWH, including clinical, virological und laboratory parameters.
Analyze the rate of HDV-testing and evaluate the prevalence of HDV-infection by testing.
Evaluation of former screening of HDV by assessing existing data at study sites.
Determination of the HDV prevalence in European PLWH and HBV coinfection.
Setting up a database of all PLWH with HBV/HDV coinfection
Analysis of transmission risk factors for HDV coinfection
Asses the rate of HDV positive patients with ongoing HDV replication.
Define the liver disease state by APRI score, fibroscan, ultrasound and routine laboratory test results.

开始日期2024-05-01

申办/合作机构

Universitätsklinikum Bonn

[+10]

NCT06140381 / RecruitingN/A

Characterization of the Neuromuscular and Biomechanical Properties of Spastic Myopathy-affected Muscles During the Generation of Passive and Active Force: the Effect of a Management Program Based on Eccentric Exercises.

The goal of this study is to compare between Eccentric training and conventional therapy in sub-acute stroke survivors. The primary objective of this study is to evaluate improvements in gait speed after four months of ET in comparison to conventional therapy for patients with sub-acute stroke. Secondary objectives involve assessing: i) modifications in neuromuscular parameters of PF, ii) changes in muscle stiffness within PF during passive mobilization and active force generation, and iii) modifications in architectural parameters of PF.

开始日期2023-12-01

申办/合作机构

Centre hospitalier universitaire Henri-Mondor

NCT05912608 / Enrolling by invitationN/A

Searching Optimal Tailored Strategy for Repair of Acute Type A Acute Aortic Dissection

Acute type A aortic dissection (TAAD) persists as a clinicopathologic entity with high lethality in the current era. Several procedures are presently used to repair the TAAAD. The objective of this study is to analyze two groups of individuals using a conservative approach through root-sparing and hemiarch techniques in patients who are hospitalized in higher-risk clinical conditions or more aggressive procedures such as root replacement and total arch replacement in low-risk patients.

开始日期2023-10-30

申办/合作机构

Société d'Exploitation du Centre Cardiologique du Nord SA

[+2]

100 项与 Centre hospitalier universitaire Henri-Mondor 相关的临床结果

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400

项与 Centre hospitalier universitaire Henri-Mondor 相关的文献（医药）

2024-09-18·Science Translational Medicine

Preschool-age children maintain a distinct memory CD4 ⁺ T cell and memory B cell response after SARS-CoV-2 infection

Article

作者: Manfroi, Benoît ; Pottez-Jouatte, Valentine ; Lorrot, Mathie ; Mahuteau-Betzer, Florence ; Leite-de-Moraes, Maria ; Attia, Mikaël ; Fillatreau, Simon ; Aubart, Mélodie ; Ouldali, Naim ; Walczak, Aleksandra M. ; Temmam, Sarah ; Sermet-Gaudelus, Isabelle ; Reynaud, Claude-Agnès ; Briand, Nelly ; Faye, Albert ; Pohar, Jelka ; Bacher, Petra ; Tartour, Eric ; Galeotti, Caroline ; Lezmi, Guillaume ; Cuc, Bui Thi ; Van Endert, Peter ; Chappert, Pascal ; Vandenberghe, Alexis ; Nguyen, Ngan Thu ; Hulot, Jean-Sébastien ; de truchis de Lays, Camille ; Michel, Marc ; Sokal, Aurélien ; Courbebaisse, Marie ; Romain, Anne-Sophie ; Mahévas, Matthieu ; Weill, Jean-Claude ; Morelle, Guillaume ; Semeraro, Michaela ; Arnould, Marc Duval ; El Behi, Mohamed ; Amouyal, Elsa ; Salem-Wehbe, Layale ; Languille, Laetitia ; Benoist, Grégoire ; Beauvineau, Claire ; Camaglia, Francesco ; Blanchard, Anne ; Luka, Marine ; Eloit, Marc ; Ménager, Mickael ; Borzakian, Sibyline ; Martin, Roland ; Crétolle, Célia ; Scheffold, Alexander ; Berthaud, Romain ; Mora, Thierry ; Elenga, Narcisse

The development of the human immune system lasts for several years after birth. The impact of this maturation phase on the quality of adaptive immunity and the acquisition of immunological memory after infection at a young age remains incompletely defined. Here, using an antigen-reactive T cell (ARTE) assay and multidimensional flow cytometry, we profiled circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–reactive CD3 + CD4 + CD154 + T cells in children and adults before infection, during infection, and 11 months after infection, stratifying children into separate age groups and adults according to disease severity. During SARS-CoV-2 infection, children younger than 5 years old displayed a lower antiviral CD4 + T cell response, whereas children older than 5 years and adults with mild disease had, quantitatively and phenotypically, comparable virus-reactive CD4 + T cell responses. Adults with severe disease mounted a response characterized by higher frequencies of virus-reactive proinflammatory and cytotoxic T cells. After SARS-CoV-2 infection, preschool-age children not only maintained neutralizing SARS-CoV-2–reactive antibodies postinfection comparable to adults but also had phenotypically distinct memory T cells displaying high inflammatory features and properties associated with migration toward inflamed sites. Moreover, preschool-age children had markedly fewer circulating virus-reactive memory B cells compared with the other cohorts. Collectively, our results reveal unique facets of antiviral immunity in humans at a young age and indicate that the maturation of adaptive responses against SARS-CoV-2 toward an adult-like profile occurs in a progressive manner.

2024-09-01·Thorax

Epidemiology of childhood interstitial lung disease in France: the RespiRare cohort

Article

作者: Fleury, Manon ; Schweitzer, Cyril ; Clement, Annick ; Berteloot, Laureline ; Egron, Carole ; Thumerelle, Caroline ; Borie, Raphael ; Guiddir, Tamazoust ; Vigier, Clémentine ; Renoux, Marie-Catherine ; Labbé, Guillame ; Epaud, Ralph ; Roditis, Léa ; Le Clainche Viala, Laurence ; Bessaci, Katia ; Labouret, Géraldine ; Tatopoulos, Aurélie ; Ladaurade, Alice ; Deneuville, Eric ; Reix, Philippe ; Corvol, Harriet ; Trioche-Eberschweiler, Pascale ; Cros, Pierrick ; Jarreau, Pierre-Henri ; Gertini, Isabelle ; Coutier, Laurianne ; Cantais, Aurélie ; Weiss, Laurence ; Forgeron, Aude ; Gachelin, Elsa ; Jedidi, Nouha ; Cisterne, Camille ; Houdouin, Véronique ; Gourdan, Pierre ; Fletcher, Camille ; Marguet, Christophe ; Galode, François ; Giovannini-Chami, Lisa ; Mazenq, Julie ; Perisson, Caroline ; Hullo, Églantine ; Coulomb, Aurore ; Ducou le Pointe, Hubert ; Sileo, Chiara ; Hadchouel, Alice ; Dalphin, Marie-Laure ; Dubus, Jean-Christophe ; Delestrain, Céline ; Herzog, Audrey ; Rames, Cinthia ; Troussier, Françoise ; Fayon, Michael ; Brouard, Jacques ; Masson-Rouchaud, Alexandra ; Benhamida, Myriam ; de Becdelievre, Alix ; Louvrier, Camille ; Nathan, Nadia ; Legendre, Marie ; Bilhouee, Tiphaine ; Delacourt, Christophe

IntroductionInterstitial lung disease in children (chILD) are rare and mostly severe lung diseases. Very few epidemiological data are available in limited series of patients. The aim of this study was to assess the prevalence and incidence of chILD in France.MethodsWe performed within the RespiRare network a multicentre retrospective observational study in patients with chILD from 2000 to 2022 and a prospective evaluation of chILD’s incidence between February 2022 and 2023.ResultschILD was reported in 790 patients in 42 centres. The estimated 2022 prevalence in France was 44 /million children (95% CI 40.76 to 47.46) and the computed incidence was 4.4 /million children (95% CI 3.44 to 5.56). The median age at diagnosis was 3 months with 16.9% of familial forms. Lung biopsy and genetic analyses were performed in 23.4% and 76.9%, respectively. The most frequent chILD aetiologies in the <2 years group were surfactant metabolism disorders (16.3%) and neuroendocrine cell hyperplasia of infancy (11.8%), and in the 2–18 years group diffuse alveolar haemorrhage (12.2%), connective tissue diseases (11.4%), hypersensitivity pneumonitis (8.8%) and sarcoidosis (8.8%). The management included mainly oxygen therapy (52%), corticosteroid pulses (56%), oral corticosteroids (44%), azithromycin (27.2%), enteral nutrition (26.9%), immunosuppressants (20.3%) and hydroxychloroquine (15.9%). The 5-year survival rate was 57.3% for the patients diagnosed before 2 years and 86% between 2 and 18 years.ConclusionThis large and systematic epidemiological study confirms a higher incidence and prevalence of chILD than previously described. In order to develop international studies, efforts are still needed to optimise the case collection and to harmonise diagnostic and management practices.

2024-09-01·Revue Neurologique

Metabolic syndrome and the phenotype of multiple sclerosis

Article

作者: Bapst, B ; Zedet, M ; Baldé, S ; Wahab, A ; Créange, A ; Lafont, C ; Gauthier, H

BACKGROUNDComorbidities, particularly vascular comorbidities, have been shown to exacerbate the progression of disability in multiple sclerosis (MS). Metabolic syndrome (MetS) is a cluster of conditions including abdominal obesity, insulin resistance, atherogenic dyslipidemia, and vascular dysfunction, which contribute to vascular morbidity and chronic inflammation.OBJECTIVETo describe the characteristics of MetS in a cohort of MS patients and evaluate its relationship with the MS phenotype.METHODSA monocentric cohort study was conducted on MS patients, collecting demographic, clinical, radiological, and therapeutic data, as well as metabolic data including waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose.RESULTSAmong the 84 patients included in the study, 27% were diagnosed with MetS. MetS was found to be associated with secondary progressive MS (SPMS). Patients with SPMS had a higher prevalence of MetS compared to those with relapsing-remitting MS (RRMS), even after adjusting for disease duration. While MetS was associated with Expanded Disability Status Scale (EDSS) progression in the 3-year period according to univariate analysis, it did not show a significant association with disease activity.CONCLUSIONThis study provides evidence supporting the connection between MetS and the progression of disability in MS, independent of disease relapse activity.

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