A Randomized, Double-Blind Study Evaluating the Efficacy, Safety and Tolerability of XtraBosTM (Boswellia Serrata Extract) Compared with Placebo in participants with Osteoarthritis Associated with Hypertension or Neuropathic Pain, or Sleep Disorder. - NIL

开始日期2023-07-28

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2019-11-01·Homeopathy4区 · 医学

Current Status of Expiry of Homeopathic Medicines in Brazil, Germany, India and the United States: A Critical Review

4区 · 医学

Review

作者: Cesar, Amarilys ; Valavan, Ramachandran

Background Assignment of expiry date to homeopathic medicines is a subject of important concern to its pharmacists and practitioners. This study compares the regulatory framework for the expiry of homeopathic medicines in four countries: Brazil, Germany, India and the United States. Findings Different or no expiry periods are variously followed. Whereas Germany, with some exceptions, employs a maximum expiry of 5 years for both potencies and finished products, Brazil adopts a 5-year expiry for finished products only, potencies used in manufacture being exempted from an assigned expiry date. In India, all homeopathic medicines except dilutions and back potencies have a maximum of 5 years' shelf-life, including those supplied to consumers. In the United States, homeopathic medicines are exempted from expiry dates. Comments There is neither a rational basis nor scientific evidence for assigning a short (3–5 years) expiry period for homeopathic medicines as followed in some of the countries, particularly in light of the fact that some studies have shown homeopathic medications to be effective even after 25 years. Homeopathic ultra-dilutions seem to contain non-material activity that is maintained over time and, since these exhibit different chemical properties compared to the original starting material, it is quite possible they possess properties of longer activity than conventional medicines. Regulators should acknowledge this feature and differentiate expiry of homeopathic medicinal products from that of conventional drugs.

International Journal for Pharmaceutical Research Scholars

Application of high performance liquid chromatography to the determination and validation of levodopa in Mucuna pruriens L

作者: Kalakoti, B. S. ; Singh, B. P. ; Upadhyay, V. ; Sharma, N. ; Tiwari, A. K. ; Joshi, H. M.

The seeds of Mucuna pruriens L. were extracted with 40% ethyl-alc., 60% water with 1.5% glacial acetic acid for the detection of levodopa and some physico-chem. parameters.A sensitive, precise and accurate high-performance liquid chromatog. (HPLC) method was developed for the quant. estimation of levodopa in Mucuna pruriens extractThe method utilizes sample preparation step followed by separation on a Phenomenex C₁₈, 250 × 4.6 mm, 5 μm particle size column, using 0.1 M KH₂PO₄ (pH 3.0 by ortho-phosphoric acid) as the mobile phase.Anal. of levodopa was carried out in the absorbance mode at 283 nm.The method was validated in terms of linearity, precision (inter and intraday), accuracy, limit of detection (LOD) and limit of quantification (LOQ).Linearity was observed in the range of 20-100 ppm with correlation coefficient of 0.9991.Detection limit was 5.6 ppm and quantification limit was 8.5 ppm.The repeatability of the method was found to be 0.49% and recovery values from 101.17 to 100.18 % indicates best accuracy of the method.The results indicated that the extract obtained was 50% Levodopa content and 38% protein content.The proposed HPLC method was also found to be precise, specific, accurate and can be used for the identification and quant. determination of levodopa in herbal extracts

International Journal of pharma and Bio Sciences

Antioxidant and antimicrobial effect of turmeric oil, boswellia oil and neem oil on pathogenic and food spoilage microorganisms

作者: Choudhary, Sheetal ; Gaba, Goldie ; Sharma, Naveen ; Haneef, Mohammad ; Sharma, Amit

Oils extracted from the parts of plant possess a plethora of ethno botanical activity.They have been extensively utilized in perfume, food, pharmaceutical and cosmetic industry as fragrances, flavoring and therapeutic agents.This study investigates antioxidant and antimicrobial potential of herbal essential oils namely turmeric, neem and boswellia in order to extend their protective activity against infections and food spoilage.The microorganisms utilized in the research were a strain of gram pos. bacteria; Staphylococcus aureus, gram neg. bacteria: Escherichia coli and two strains of fungi: Candida albicans and Aspergillus brasiliensis.The essential oils were extracted inhouse by adopting methods standardized for industrial purposes.The antioxidant potential of the obtained essential oils was analyzed by FRAP assay while antimicrobial effect was examined by the percentage of growth inhibition on test microorganisms.Viable strains were nurtured in culture media over a period of 21 days to observe the antimicrobial potential.The results from the present study revealed strong antioxidant potential of Turmeric oil followed by Boswellia oil and least effect was seen in case of neem oil.The antibacterial effect against both the strains Staphylococcus aureus (NCIM-5345, Pune) and Escherichia coli was observed to be Turmeric oil ≥ Boswellia oil >Neem oil.It was concluded that Turmeric oil and Boswellia oil exhibited marked antioxidant and antimicrobial activity.

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