This study aims to evaluate the effects of abdominal massage on gastrointestinal functions in mechanically ventilated patients receiving enteral nutrition in intensive care units.

开始日期2024-12-02

申办/合作机构

Mersin University

NCT06661109 / Not yet recruitingN/AIIT

Innovative Methods in Postsurgical Pain Management: A Randomized Controlled Trial on the Effects of Kinesio Taping After Cesarean Section

Brief Summary:
This randomized, single-blind study aimed to evaluate the effects of kinesio taping on pain management, comfort, and satisfaction of women after cesarean section.
The main question(s) it aimed to answer were:
* Is there a difference in mean pain scores between the intervention group and the control group as a result of kinesio taping?
* Is there a difference in mean comfort levels between the intervention group and the control group as a result of kinesio taping?

开始日期2024-12-02

申办/合作机构

Mersin University

[+1]

NCT06635551 / Not yet recruitingN/AIIT

Comparison of Vascular Catheter-Related Thrombosis and Risk Factors Using Daily Bedside Ultrasonography After Oncologic and Non-Oncologic Major Surgery

The aim of this study was to prospectively evaluate vascular catheter-related thrombosis and risk factors using daily bedside ultrasonography after oncologic and non-oncologic major surgery.

开始日期2024-11-01

申办/合作机构

Mersin University

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0 项与 Mersin University 相关的专利（医药）

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项与 Mersin University 相关的文献（医药）

2025-01-01·Separation and Purification Technology

A facile detachable catalyst support: Green synthesis of Ag nanoparticles, immobilizing into waste corn husk fibers, evaluation of photocatalytic performance and bioactivity analysis

作者: Tollu, Gulsah ; Nawfal Mahmood Al-Nuaimy, Maryam ; Yabalak, Erdal ; Ozdemir, Sadin

The escalating demand for metallic nanoparticles (Nps) is propelled by their expanding utility in environmental and biomedical disciplines.To enhance the efficiency of wastewater treatment, nanotechnol., renowned for its environmentally friendly properties, has been strategically employed.Nano-metals, distinguished for their photocatalytic and antimicrobial capabilities, were harnessed in this investigation.A biochem. synthesis method involving the green synthesis of environmentally friendly and non-toxic AgNps, utilizing Myrtus communis leaf extract, was implemented.The subsequent immobilization of these synthesized nanoparticles into corn husk fibers facilitated the photocatalytic degradation of Crystal Violet dye, yielding an impressive 96 % removal efficiency.The optimization of methodologies using Central Composite Design was validated through ANOVA.Surface properties were comprehensively assessed through SEM-EDS and FT-IR analyses, while crystal structure elucidation was achieved via XRD anal.The synthesized AgNps showcased notable antioxidant activity, registering 90.61 % efficacy even at a modest concentration of 100 mg/L.Microdilution assays underscored the consequential antibacterial and antifungal activities against diverse microorganisms.Notably, AgNps exhibited substantial antibiofilm efficacy, reaching peak rates of 89.63 % and 81.75 % against S. aureus and P. aeruginosa at 20 mg/L, resp.Furthermore, E. coli cell viability was markedly impeded, displaying a 95.87 % reduction compared to the control at a concentration of 20 mg/L.In summation, AgNps manifest noteworthy antimicrobial, antioxidant, cell viability, and antidiabetic potential.Their integration into photocatalytic processes offers a nuanced strategy for environmental remediation, coupling heightened pollutant degradation with inherent antibacterial attributes, thereby advancing the evolution of effective and sustainable water treatment technologies.

2024-12-01·Journal of Molecular Structure

Synthesis, structural diversity, supramolecular architecture, and catalytic reactions of mononuclear and heteronuclear benzamide cobalt complexes

作者: Arslan, Hakan ; Solmaz, Ummuhan

Two NNN-type benzamide derivative ligands {N,N′-(2,2′-azenidiyl-bis(2,1-phenylene))dicyclohexanecarboxamide (H₃L^cyHex) and N,N′-(2,2′-azenidiyl-bis(2,1-phenylene))dicyclobutanecarboxamide (H₃L^cyBu)} that incorporate N-amidate donors have been synthesized and characterized by ¹H NMR, ¹³C NMR, and FT-IR techniques.Subsequently, heterometallic trinuclear cobalt-potassium complexes, [K₂(DMF)₆Co(HL)₂] (K^CyBu and K^CyHex) and mononuclear cobalt complexes with complementary tetraethylammonium ions, [Et₄N]₂[Co(HL)₂] (E^CyBu and E^CyHex), both incorporating these ligands, have been synthesized.Suitable crystals for single-crystal X-ray diffraction of H₃L^cyHex and K^CyBu have been characterized using single-crystal X-ray diffraction anal.Intermol. interactions play a major role in the formation of the supramol. architecture in the crystal lattice of compoundsThe supramol. structures in H₃L^cyHex are formed through intermol. CH···O, CH···π, CH···O/N, and CH···N interactions, and those in K^CyBu are generated by CH···π and CH···O intermol. interactions.The amphoteric properties exhibited by new cobalt-oxygen species produced through the reaction of cobalt complexes with mol. oxygen were examined by their electrophilic reactivity in the conversion of triphenylphosphine (PPh₃) to triphenylphosphoxide (OPPh₃) and their nucleophilic reactivities in the deformylation reaction of 2-phenylpropionaldehyde (2-PPA) to acetophenone (catalyst/substrate ratio, 1:100).In the catalytic activity results, it was observed that the cobalt-oxygen complexes have an amphoteric feature due to their good reactivity in both reactions.

2024-12-01·Molecular Biology Reports

Interaction of olive oil-based propolis and caffeic acid phenethyl ester with methylprednisolone used in the treatment of human acute myeloid leukemia

Article

作者: Ozcimen, A Ata ; Silici, Sibel ; Dogan, Hamide

BACKGROUNDMethylprednisolone (MP) is a pharmaceutical agent employed in the management of Leukemia, which is a systemic malignancy that arises from abnormalities in the hematological system. Numerous investigations in the field of cancer research have directed their attention towards propolis, a natural substance with significant potential as a treatment-supportive agent. Its utilization aims to mitigate the potential adverse effects associated with chemotherapy medications. The objective of this study was to examine the impact of olive oil-based propolis (OEP) and caffeic acid phenethyl ester (CAPE) on the treatment of acute myeloid leukemia, as well as to determine if they exhibit a synergistic effect when combined with the therapeutic support product methylprednisolone.METHODS AND RESULTSThe proliferation of HL-60 cells was quantified using the WST-8 kit. The PI Staining technique was employed to do cell cycle analysis of DNA in cells subjected to OEP, CAPE, and MP, with subsequent measurement by flow cytometry. The apoptotic status of cells was determined by analyzing them using flow cytometry after staining with the Annexin V-APC kit. The quantification of apoptotic gene expression levels was conducted in HL-60 cells. In HL-60 cells, the IC₅₀ dosages of CAPE and MP were determined to be 1 × 10^- 6 M and 5 × 10^- 4 M, respectively. The HL-60 cells were subjected to apoptosis and halted in the G₀/G₁ and G₂/M phases of the cell cycle after being treated with MP, CAPE, and OEP.CONCLUSIONSPropolis and its constituents have the potential to serve as effective adjunctive therapies in chemotherapy.

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100 项与 Mersin University 相关的转化医学

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