Delving into the Latest Updates on Hebei People's Hospital with Synapse

概览

疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

自体CAR-T	1

排名前五的靶点	数量

PSCA(前列腺干细胞抗原)	1

关联

1

项与 Hebei People's Hospital 相关的药物

Anti-PSCA CAR-T (Hebei People's Hospital)

靶点

PSCA

作用机制

PSCA抑制剂

在研机构

Hebei People's Hospital

原研机构

Hebei People's Hospital

在研适应症

去势抵抗性前列腺癌

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

首次获批日期-

130

项与 Hebei People's Hospital 相关的临床试验

ChiCTR2400089018 / SuspendedN/AIIT

Study on Related Factors and Mechanisms of Behavioral Addiction in Adolescents with Non-suicidal Self-injury

开始日期2024-09-01

申办/合作机构

Hebei People's Hospital

ChiCTR2400086232 / SuspendedIIT

Application of dexmedetomidine in monitoring anesthesia during intervertebral foramen endoscopy

开始日期2024-07-01

申办/合作机构

Hebei People's Hospital

ChiCTR2400085979 / SuspendedIIT

Application of intravenous injection of lidocaine in monitoring anesthesia during intervertebral foramen endoscopy

开始日期2024-07-01

申办/合作机构

Hebei People's Hospital

100 项与 Hebei People's Hospital 相关的临床结果

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0 项与 Hebei People's Hospital 相关的专利（医药）

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2,572

项与 Hebei People's Hospital 相关的文献（医药）

2025-01-01·Brain Research

The role of trimethylation on histone H3 lysine 27 (H3K27me3) in temozolomide resistance of glioma

Article

作者: Li, Li ; Li, Yitong ; Guo, Xiaoqiang ; Sui, Aixia ; Dong, Changzheng ; Zhang, Xiaopei ; Shi, Jian

Temozolomide (TMZ) is the first-line chemotherapeutic agent for malignant glioma, but its resistance limited the benefits of the treated patients. In this study, the role and significance of trimethylation of histone H3 lysine 27 (H3K27me3) in TMZ resistance were investigated. Data from twenty advanced glioma patients were collected, and their pathological samples were analyzed for H3K27me3 levels. TMZ sensitivity was compared between glioma cells U87 and TMZ-resistant cells U87TR, with H3K27me3 levels determined in both cells. The effects of H3K27me3 demethylases inhibitor GSK-J4, combined with TMZ, were assessed on the proliferation and migration of U87TR cells. The results indicated that a high level of H3K27me3 predicts longer disease free survival (DFS) and overall survival (OS) in glioma patients receiving TMZ treatment. The H3K27me3 level was lower in U87TR cells compared to U87 cells. GSK-J4 increased the H3K27me3 level in U87TR cells and decreased their resistance to TMZ. In summary, this study identified a novel marker of TMZ resistance in glioma and provided a new strategy to address this challenge. These findings are significant for improving the clinical treatment of glioma in the future.

2024-12-31·Renal Failure

Association between circulatory complement activation and hypertensive renal damage: a case–control study

Article

作者: Zhai, Jianlong ; Guo, Yifang ; Wang, Xinyu ; Ma, Sai ; Zhang, Guorui ; Zhang, Tingting ; He, Lili ; Zuo, Qingjuan ; Wang, Zhongli

OBJECTIVEThe aim of this study was to investigate the potential importance of complement system activation, with particular emphasis on the complement alternative pathway (AP), in the pathogenesis of hypertensive renal damage.METHODSSerum complement C3, complement Factor H (CFH) and AP activation were assessed in 66 participants with established essential hypertension with renal damage (RD). Fifty-nine patients with age- and sex-matched essential hypertension without renal damage (NRD) and 58 healthy participants (normal) were selected.RESULTSOur study revealed that C3 and AP50 continuously increased from normal to NRD to RD (p < 0.05, respectively), while CFH was significantly lower than that in NRD and healthy participants (p < 0.05, respectively). After multifactorial logistic regression analysis corrected for confounders, elevated serum C3 (p = 0.001) and decreased CFH (p < 0.001) were found to be independent risk factors for hypertension in healthy participants; elevated serum C3 (p = 0.034), elevated AP50 (p < 0.001), decreased CFH (p < 0.001), increased age (p = 0.011) and increased BMI (p = 0.013) were found to be independent risk factors for the progression of hypertension to hypertensive renal damage; elevated serum C3 (p = 0.017), elevated AP50 (p = 0.023), decreased CFH (p = 0.005) and increased age (p = 0.041) were found to be independent risk factors for the development of hypertensive renal damage in healthy participants.CONCLUSIONAbnormal activation of complement, particularly complement AP, may be a risk factor for the development and progression of hypertensive renal damage.

2024-12-31·Renal Failure

Canagliflozin attenuates kidney injury, gut-derived toxins, and gut microbiota imbalance in high-salt diet-fed Dahl salt-sensitive rats

Article

作者: Zhang, Tingting ; Wang, Zhongli ; He, Lili ; Guo, Yifang ; Zuo, Qingjuan ; Ma, Sai ; Zhang, Guorui ; Zhai, Jianlong

PURPOSETo investigate the effects of canagliflozin (20 mg/kg) on Dahl salt-sensitive (DSS) rat gut microbiota and salt-sensitive hypertension-induced kidney injury and further explore its possible mechanism.METHODSRats were fed a high-salt diet to induce hypertension and kidney injury, and physical and physiological indicators were measured afterwards. This study employed 16S rRNA sequencing technology and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based metabolic profiling combined with advanced differential and association analyses to investigate the correlation between the microbiome and the metabolome in male DSS rats.RESULTSA high-salt diet disrupted the balance of the intestinal flora and increased toxic metabolites (methyhistidines, creatinine, homocitrulline, and indoxyl sulfate), resulting in severe kidney damage. Canagliflozin contributed to reconstructing the intestinal flora of DSS rats by significantly increasing the abundance of Corynebacterium spp., Bifidobacterium spp., Facklamia spp., Lactobacillus spp., Ruminococcus spp., Blautia spp., Coprococcus spp., and Allobaculum spp. Moreover, the reconstruction of the intestinal microbiota led to significant changes in host amino acid metabolite concentrations. The concentration of uremic toxins, such as methyhistidines, creatinine, and homocitrulline, in the serum of rats was decreased by canagliflozin, which resulted in oxidative stress and renal injury alleviation.CONCLUSIONCanagliflozin may change the production of metabolites and reduce the level of uremic toxins in the blood circulation by reconstructing the intestinal flora of DSS rats fed a high-salt diet, ultimately alleviating oxidative stress and renal injury.

100 项与 Hebei People's Hospital 相关的药物交易

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100 项与 Hebei People's Hospital 相关的转化医学

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