Nottinghamshire Healthcare NHS Foundation Trust

Five key methods have been explored by researchers to calculate life expectancy and the life years lost due to disease and illness. Five key methods have been explored by Leicester researchers to calculate life expectancy and the life years lost due to disease and illness. Life expectancy measures, particularly years of life lost or gained, have captured a great interest in the last years by public health institutions and healthcare professionals given their immediate and actionable interpretation. Academics from the University of Leicester investigated the common methods used to predict the 'years of life lost' by reviewing a range of methods: from basic methods -- such as life tables -- to most recent and advanced methods using statistical modelling. They highlighted the important differences between the methods, current software used, and how they can be implemented in healthcare research and real-world settings using an example from a clinically-relevant topic of multimorbidity in the UK Biobank. According to the findings, the review found that using the same data and research question, the estimated years of life lost value differed among methods, as each method focused on estimating different quantities. The research was supported by the National Institute for Health Research (NIHR) Applied Research Collaboration (ARC) East Midlands. Lead researcher Dr Yogini Chudasama, an Epidemiologist at the Leicester Real World Evidence Unit, said: "This project was initially from my PhD, where at the time there was no simple and comprehensive paper explaining or comparing the methods for the years of life lost calculation, or showing which method I should use for my data. This was a challenging task and required a lot of patience and learning to overcome the difficulties encountered. Collaborating with co-authors and supervisor Dr Francesco Zaccardi, I was able to explore the methods in detail and understand how they are applied to real-world data." "I am very proud to have this published in the Journal of Clinical Epidemiology, as a tutorial guide for researchers and healthcare professionals, as it will help promote a better and easier understanding of life expectancy metrics in healthcare research." As a result, the researchers also developed a general life expectancy analytical programme, which has been applied to three NIHR ARC-funded published studies, published in PLOS Medicine, the Journal of Internal Medicine, and BMC Medicine. Dr Francesco Zaccardi, Clinical Epidemiologist at the University of Leicester, main supervisor for the study, said: "Findings from epidemiological studies are commonly reported in terms of relative risk -- for example, type 2 diabetes increases the risk of death by two-fold. This statement is difficult to interpret because it does not convey information on the absolute risk of death. "Years of life lost, conversely, are easily interpretable: in a middle-aged person, type 2 diabetes reduces the life expectancy by five years. As different methods exist to estimate life expectancy, in our study we highlighted that decisions should be based on the purpose of the research, the type of available data, and the required flexibility when using complex statistical modelling." Professor Kamlesh Khunti CBE, Director of NIHR ARC East Midlands and the Real World Evidence Unit and Professor of Primary Care Diabetes and Vascular Medicine at the University of Leicester, added: "This review is important as years of lost life metrics are simple summary measures that can enhance the interpretation of the findings from epidemiological studies for healthcare professionals and the public." NIHR ARC East Midlands funds vital work to tackle the region's health and care priorities by speeding up the adoption of research onto the frontline of health and social care. The organisation puts in place evidence-based innovations which seek to drive up standards of care and save time and money. NIHR ARC East Midlands is hosted by Nottinghamshire Healthcare NHS Foundation Trust and works in collaboration with the East Midlands Academic Health Science Network. It has bases at the University of Leicester and the University of Nottingham.