Delving into the Latest Updates on Naicons Srl with Synapse

概览

疾病领域	数量

感染	1
神经系统疾病	1

排名前五的药物类型	数量

小分子化药	1
重组多肽	1

排名前五的靶点	数量

TRPVs(瞬时受体电位阳离子通道亚家族V)	1

关联

4

项与 Naicons Srl 相关的药物

NAI-107

靶点

TRPVs

作用机制

TRPVs调节剂 [+1]

在研机构

Naicons Srl

原研机构

Sentinella Pharmaceuticals, Inc.

在研适应症

革兰氏阳性细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

NAI-112

靶点-

作用机制-

在研机构

Naicons Srl

原研机构

Naicons Srl

在研适应症

神经痛

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

NAI-Acne

靶点

EEF1A1

作用机制

EEF1A1抑制剂

在研机构-

原研机构

Pfizer Inc.

在研适应症-

非在研适应症

寻常痤疮

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

1

项与 Naicons Srl 相关的临床试验

EUCTR2014-001491-62-SK

/ Not yet recruiting临床2期

Clinical efficacy and safety of NAI-Acne gel 3% applied twice-a-day to patients with facial acne vulgaris - NAI-003 3% gel efficacy pilot

开始日期2014-08-11

申办/合作机构

Naicons Srl

100 项与 Naicons Srl 相关的临床结果

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0 项与 Naicons Srl 相关的专利（医药）

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5

项与 Naicons Srl 相关的文献（医药）

Lantibiotics and other antibacterial peptides

作者: Sosio, Margherita ; Donadio, Stefano

A review.Lantibiotics and other ribosomally synthesized peptides have attracted increasing attention in the search for new chem. classes of antibacterial agents effective against multidrug-resistant pathogens.Several factors have probably contributed to this resurgent interest.Among them, the realization that many different classes of ribosomally synthesized peptides were produced by almost all taxa of bacteria; that lantibiotics, being ribosomally synthesized, are amenable to the generation of analogs by codon substitutions in the structural gene; and that, by binding to biosynthetic intermediates and not directly to enzymes, resistance in bacterial pathogens cannot be simply acquired by mutations in the target enzymes.In this chapter, the authors will review the chem., biosynthesis, occurrence and mechanism of action of lanthipeptides, with particular focus on lantibiotics.The authors will also present three lantibiotics that are currently under advanced preclin. or early clin. development, as well as some recently discovered compounds which represent improved variants of known lantibiotics.

Natural Product Reports1区 · 化学

Challenges and advances in genetic manipulation of filamentous actinomycetes – the remarkable producers of specialized metabolites

1区 · 化学

Review

作者: Stegmann, Evi ; Tocchetti, Arianna ; Sosio, Margherita ; Musiol-Kroll, Ewa M.

Challenges and advances in genetic manipulation of actinomycetes.

RSC Advances

Allopeptimicins: unique antibacterial metabolites generated by hybrid PKS-NRPS, with original self-defense mechanism in Actinoallomurus

作者: Landini, Paolo ; Sosio, Margherita ; Iorio, Marianna ; Brunati, Cristina ; Tocchetti, Arianna ; Donadio, Stefano ; Maffioli, Sonia Ilaria ; Gentile, Andrea

In the search for structurally novel metabolites with antibacterial activity, innovative approaches must be implemented to increase the probability of discovering novel chem. from microbial sources.Here we report on the application of metabolomic tools to the genus Actinoallomurus, a poorly explored member of the Actinobacteria.From examining extracts derived from 88 isolates belonging to this genus, we identified a family of cyclodepsipeptides acylated with a C20 polyketide chain, which we named allopeptimicins.These mols. possess unusual structural features, including several double bonds in the amino-polyketide chain and four non-proteinogenic amino acids in the octapeptide.Remarkably, allopeptimicins are produced as a complex of active and inactive congeners, the latter carrying a sulfate group on the polyketide amine.This modification is also a mechanism of self-protection in the producer strain.The structural uniqueness of allopeptimicins is reflected in a biosynthetic gene cluster showing a mosaic structure, with dedicated gene cassettes devoted to formation of specialized precursors and modular assembly lines related to those from different pathways.

100 项与 Naicons Srl 相关的药物交易

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100 项与 Naicons Srl 相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床前

2

其他

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当前项目

药物(靶点)	适应症	全球最高研发状态

NAI-112	神经痛更多	临床前
NAI-107 ( TRPVs )	革兰氏阳性细菌感染更多	临床前
NAI-802	革兰氏阳性细菌感染更多	无进展
NAI-Acne ( EEF1A1 )	寻常痤疮更多	无进展