Effectiveness of a Modified Cost-Effective Dietary Plan in Promoting Weight Loss and Preservation of Lean Body Mass in Patients After Bariatric Surgery

This study will see if a low-cost dietary plan, based on the standard dietary guidelines of the American Society for Metabolic and Bariatric Surgery (ASMBS) and using locally available foods, can help patients lose weight and keep their lean body mass after bariatric surgery. It will also check if this plan can maintain healthy levels of important nutrients such as vitamin B12, iron, and vitamin D.
Patients who have undergone bariatric surgery will be randomly assigned to follow either the low-cost diet or the regular hospital diet. Their weight, body composition, and nutrient levels will be tracked at baseline, and at 1, 3, and 6 months after surgery.
The aim is to find out if this simpler, affordable diet, which follows international standards, works as well as the regular plan while being easier for low-income patients to follow.

开始日期2025-10-01

申办/合作机构

Khyber Teaching Hospital

NCT07294963

/ RecruitingN/AIIT

Impact of Lifestyle Interventions on Cognitive Decline in NAFLD: A Randomized Controlled Trial of Liver Fibrosis, Hormonal Imbalance, and Inflammatory Markers

This study investigates whether a structured lifestyle program can help improve thinking skills and liver health in adults with Non-Alcoholic Fatty Liver Disease (NAFLD). We are enrolling 45 participants, aged 18-42, who will be randomly assigned to one of three groups for six months: one receiving general health advice, a second following a supervised Mediterranean diet plan, and a third combining the same diet with a regular walking program. The main goal is to see if these diet and exercise interventions can lead to better scores on memory and reasoning tests, reduce liver stiffness measured by a painless scan (FibroScan), and improve related blood markers of inflammation and hormone balance.

开始日期2025-10-01

申办/合作机构

Khyber Medical University

[+1]

ACTRN12625001007426

/ Not yet recruiting临床4期IIT

comparison of efficacy and safety of apremilast and methotrexate in moderate to severe psoriasis : a randomized control trial

开始日期2025-09-15

申办/合作机构

Khyber Teaching Hospital

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项与 Khyber Teaching Hospital 相关的文献（医药）

2025-12-01·Journal of Gastrointestinal Cancer

Comparing ICG-Guided vs. Conventional Laparoscopic Lymphadenectomy in Gastric Cancer: A Systematic Review and Meta-Analysis

Review

作者: Sajjad, Fatima ; Afridi, Abdullah ; Nisa, Farwa ; Khan, Hanifullah ; Shahid, Iqra ; Khan, Muhammad Hamza ; Bacha, Zaryab ; Khan, Iqra ; Khattak, Fazia ; Afridi, Rizwan ; Ali, Muhammad Abdullah ; Kamil, Kamil Ahmad ; Qadri, Maria ; Saleem, Yasir ; Khan, Hafsa ; Habib, Hira

BACKGROUND:

Gastric cancer remains one of the leading causes of cancer-related mortality worldwide, with surgical intervention being a critical aspect of treatment. Lymphadenectomy plays a significant role in managing gastric cancer, with the extent of lymph node removal often influencing survival outcomes. Recent advancements in laparoscopic surgery have introduced the use of indocyanine green (ICG) fluorescence guidance to improve the accuracy and effectiveness of lymphadenectomy. However, the comparative efficacy of ICG-guided laparoscopic lymphadenectomy versus conventional techniques remains a topic of ongoing investigation.

AIM:

This study aims to evaluate the effectiveness and surgical outcomes of ICG-guided laparoscopic lymphadenectomy compared to conventional laparoscopic lymphadenectomy in patients with gastric cancer.

METHODS:

A systematic review and meta-analysis, based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statements, was conducted (PROSPERO: CRD420251039604). A literature review was performed (sources: PubMed, Embase, and Cochrane Library databases; end-of-search date: April 22, 2025) and quality assessment was performed using the ROB 2 and Newcastle-Ottawa Scale. A random-effects model was used to pool the data for the meta-analyses.

RESULTS:

A total of 3996 patients from ten studies were analyzed, with 1870 undergoing ICG-guided surgery and 2126 in the non-ICG group. ICG use was associated with significantly improved 1-year (RR = 1.04) and 2-year (RR = 1.09) overall survival, and a greater number of retrieved lymph nodes (MD = 6.00). While intraoperative blood loss was significantly reduced with ICG (MD = - 14.44 mL), no significant differences were observed in metastatic lymph node count, postoperative complications, operative time, or hospital stay.

CONCLUSIONS:

ICG-guided surgery in gastric cancer is associated with improved short- and mid-term overall survival and enhanced lymph node retrieval. It also significantly reduces intraoperative blood loss without increasing postoperative complications, operative time, or hospital stay. These findings support the clinical value of ICG in improving surgical outcomes.

2025-10-20·Cureus Journal of Medical Science

Autologous Fat Grafting Versus Alloplastic Materials in Post-Traumatic Urogenital Reconstruction

Article

作者: Haq, Ikram ; Khan, Hira ; Farooq, Muhammad Moazzam ; Rizwan, Muhammad ; Gilani, Fatima ; Umar, Zeeshan ; Ullah Khan, Wajahat ; Aziz, Umar

BACKGROUND:

Traumatic soft tissue injuries to the urogenital area need reconstructive procedures that minimize complications while restoring both shape and function.

OBJECTIVE:

To compare the reconstructive outcomes of autologous fat grafting versus alloplastic materials in the repair of post-traumatic urogenital soft tissue defects with respect to complication rates, aesthetic outcomes, and patient-reported satisfaction in a collaborative plastic surgery-urology clinical setting.

METHODOLOGY:

This was a descriptive, multicenter observational study conducted from November 2022 to October 2024 at Shifa International Hospitals, Islamabad, along with Khyber Teaching Hospital, Peshawar, and Hayatabad Medical Complex, Peshawar. Out of 204 patients with post-traumatic urogenital abnormalities who were at least 18 years old, 106 had autologous fat grafting, and 98 had alloplastic repair. At six and 12 months, prospective data were gathered on demographics, injury features, surgical parameters, postoperative complications, cosmetic results (as judged by a panel of blinded people), and patient satisfaction (5-point Likert scale). IBM Corp. Released 2020. IBM SPSS Statistics for Windows, Version 26. Armonk, NY: IBM Corp. was used for statistical analysis, which includes chi-square, t-tests, and multivariable regression.

RESULTS:

Mean surgical time was shorter in the fat grafting group (92.4 ± 18.1 min vs. 103.7 ± 20.9 min, p=0.002), with reduced hospital stay (1.8 ± 0.6 vs. 2.4 ± 1.1 days, p=0.001). Complication rates were significantly lower for fat grafting: infection in 5/106 patients (4.72%) vs. 14/98 (14.29%), p=0.018; extrusion in 0/106 (0%) vs. 9/98 (9.18%), p=0.003; fibrosis in 4/106 (3.77%) vs. 12/98 (12.24%), p=0.021. Excellent aesthetic scores at 12 months were achieved in 61/106 patients (57.55%) vs. 31/98 (31.63%), p=0.001, while very high satisfaction was reported by 58/106 (54.72%) vs. 29/98 (29.59%), p=0.001.

CONCLUSION:

Autologous fat grafting yields superior functional and aesthetic outcomes with fewer complications compared to alloplastic materials in post-traumatic urogenital reconstruction.

2025-09-19·Cureus Journal of Medical Science

Comparison of Core Decompression and Fibular Strut Graft in Early Avascular Necrosis of the Hip: Assessment of Postoperative Pain and Functional Outcomes

Article

作者: Afridi, Asif ; Naqqash, Muhammad ; Ahmad, Bilal ; Ahmad, Maria ; Yousaf, Haroon ; Khan, Mubbshir ; Ali Jan, Atizaz

INTRODUCTION:

There is limited local data comparing the outcomes of core decompression and fibular strut grafting in early-stage avascular necrosis (AVN) of the hip. International findings may not be directly applicable due to population-specific factors such as genetics, lifestyle, and healthcare access. Early identification of the optimal surgical option is essential for improving patient counseling, postoperative recovery, and overall clinical outcomes.

OBJECTIVE:

To compare postoperative pain and functional outcomes of core decompression versus fibular strut grafting in patients with early-stage AVN of the hip.

METHODOLOGY:

This prospective, randomized comparative cohort study was conducted at the Department of Orthopedic Surgery, Khyber Teaching Hospital, Peshawar, from 14th March 2023 to 13th September 2023. A total of 112 patients aged 18-50 years with Ficat and Arlet stage I-II AVN were enrolled and equally allocated into the core decompression or fibular strut graft groups using blocked randomization. Postoperative pain was assessed at 12 weeks using the visual analog scale (VAS), with a score >3 considered significant. Functional status was evaluated using the Hip Disability and Osteoarthritis Outcome Score (HOOS). Data were analyzed using chi-square tests for categorical variables and appropriate tests for functional scores, with p ≤ 0.05 considered statistically significant.

RESULTS:

Significant postoperative pain (VAS > 3) was observed in 11 (19.6%) patients in the core decompression group and 17 (30.4%) in the fibular strut graft group (χ² = 1.708, p = 0.190). Stratification by age, gender, and BMI consistently showed lower pain rates in the core decompression group, though differences were not statistically significant. HOOS functional scores demonstrated a similar trend favoring core decompression, but these differences also did not reach statistical significance.

CONCLUSION:

Core decompression was associated with fewer patients experiencing significant postoperative pain and showed a trend toward better short-term functional outcomes compared to fibular strut grafting. Its minimally invasive nature may make it a preferable option for early pain management in patients with early-stage AVN of the hip. However, the lack of statistical significance and the short follow-up period warrant further studies with larger sample sizes and inclusion of long-term functional and radiological outcomes before definitive clinical recommendations can be made.

项与 Khyber Teaching Hospital 相关的新闻（医药）

2025-01-02

·drugs

More Than Half of People With Rheumatoid Arthritis Have Anemia

THURSDAY, Jan. 2, 2025 -- Anemia is prevalent among patients with rheumatoid arthritis (RA), according to a study published online Oct. 26 in Cureus . Jamal Shah, M.B.B.S., from Khyber Teaching Hospital in Peshawar, Pakistan, and colleagues examined the prevalence of anemia among 330 patients with RA presenting at a tertiary care hospital in 2023. The researchers found that more than half of participants had anemia (54.55 percent). The mean hemoglobin level among these patients was 11.41 g/dL, and the red blood cell count averaged 4.26 million/µL. The Disease Activity Score was higher in patients with anemia (mean of 5.23 versus 4.98 in those without anemia). Most people with anemia had elevated C-reactive protein levels (83.33 percent; mean C-reactive protein, 28.79 mg/L) and an elevated erythrocyte sedimentation rate (88.89 percent; mean erythrocyte sedimentation rate, 45.17 mm/hour). There were significant associations observed between anemia and longer disease duration, higher RA severity, and increased inflammatory markers. "These findings underscore the critical importance of routine screening and management of anemia in RA patients, particularly those with severe or prolonged disease, as addressing anemia could enhance overall patient outcomes and quality of life," the authors write. "Future research should focus on elucidating the mechanisms linking RA and anemia, conducting longitudinal studies to better understand these associations over time, and evaluating the effectiveness of anemia treatments in improving patient health." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

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