Effectiveness and Safety Dosing of Sodium Bicarbonate in Women With Obstructed Labor in Eastern Uganda: A Phase III Randomized Placebo-controlled Trial

The goal of this clinical trial is to determine a universal safe and effective dose of sodium bicarbonate for use among women with Obstructed labour to treat acidosis. It will also learn about the safety of sodium bicarbonate drug among women with Obstructed labour.
Researchers will compare sodium bicarbonate drug to normal saline (a look-alike solution) to see if sodium bicarbonate works to treat acidosis.
Participants will receive sodium bicarbonate solution or a placebo up to two doses, four hours apart.

开始日期2024-09-01

申办/合作机构

Busitema University

[+4]

PACTR202405917242393 / Suspended临床3期IIT

Effectiveness and Safety Dosing of Sodium Bicarbonate in Women with Obstructed Labor in Eastern Uganda: A Phase III Randomized placebo-controlled Trial (SoBicOL- II Study)

开始日期2024-08-01

申办/合作机构

Busitema University

NCT05685498 / CompletedN/AIIT

Peer-led HIV Self-testing to Improve HIV Testing and Linkage to HIV Care Among Men in Two Fishing Communities in Rural Uganda: a Pilot Intervention

The goal of this behavioral interventional study is to assess the feasibility and acceptability of a peer-led HIV self-testing intervention among men in two fishing communities along the shores of Lake Victoria in Uganda. The main objectives of the study are: a) to assess the feasibility of implementing a peer-led HIV self-testing intervention among men in a fishing community context; b) determine the uptake of HIV self-testing among men in the fishing communities, and c) determine linkage to and retention in HIV care among newly diagnosed HIV-positive men following peer-led HIV self-testing. Participants will:
Be administered a baseline questionnaire to assess prior HIV testing behaviors and willingness to self-test for HIV
Receive two HIV self-test kits, one for them and one for someone else that they prefer to give the kit, to determine HIV testing behaviors among men and their significant others
Be administered follow-up questionnaires at one (1), six (6) and 12 months post-baseline to determine linkage to and retention in HIV care among those testing HIV-positive, as well as linkage to appropriate HIV prevention services among those testing HIV-negative.

开始日期2022-07-18

申办/合作机构

Busitema University

[+2]

100 项与 Busitema University 相关的临床结果

登录后查看更多信息

0 项与 Busitema University 相关的专利（医药）

登录后查看更多信息

674

项与 Busitema University 相关的文献（医药）

2024-11-01·Polymer Bulletin

The effect of nanocellulose and alkali treatment on the thermal and mechanical properties of hybrid barkcloth-banana fiber reinforced polyester bio composites

作者: Sebagala, Ivan ; Tumusiime, Godias ; Rwahwire, Samson

Abstract: The interest in bio-based polymer composites is brought about by the quest for sustainable environmentally friendly materials due to the rapid depletion of petroleum resources and the desire to find solutions to environmental pollution because of synthetic composites.The purpose of this work was to study the effect of various treatments on the performance and potential use of hybrid barkcloth-banana fiber-reinforced polyester resin biocomposites particularly for interior automotive applications.Two categories of biocomposites were prepared: (1) untreated banana fibers and barkcloth, denoted by A1, B1, C1, D1, and (2) 5% sodium hydroxide (NaOH) treated banana fibers and barkcloth with nano-cellulose denoted by A, B, C, and D.Banana fibers were soaked in the alkali solution for 12 h, nanocellulose was extracted from the barkcloth using the acid hydrolysis method and applied to the barkcloth fabrics by the pad-dry-cure method with a concentration of 1% nanocellulose.The treated barkcloth had better bonding capacity with the resin and was thermally stable than the untreated barkcloth.In contrast, the alkali treatment of banana fibers led to fiber degradation, making them brittle and consequently reducing their tensile and bending strength.The mech. properties of both composites showed that sample D1 had the best tensile and flexural strength attributed to the fact that it was based on the untreated banana fibers as opposed to the degraded alkali-treated banana fibers.

2024-10-01·International Journal of Behavioral Medicine

Increased Knowledge Mediates the Effect of Game Changers for Cervical Cancer Prevention on Diffusion of Cervical Cancer Screening Advocacy Among Social Network Members in a Pilot Trial

Article

作者: Wagner, Glenn J ; Wanyenze, Rhoda K ; Nakami, Sylvia ; Luyirika, Emmanuel ; Matovu, Joseph K B ; Bouskill, Kathryn ; Beyeza-Kashesya, Jolly ; Ghai, Ishita ; Juncker, Margrethe ; Namisango, Eve

AbstractBackgroundGame Changers for Cervical Cancer Prevention (GC-CCP), a peer-led, group advocacy training intervention, increased cervical cancer (CC) prevention advocacy not only among intervention recipients, but also their social network members (referred to as “alters”) who were targeted with advocacy in a pilot randomized controlled trial. We examined mediators and moderators of this effect on alter advocacy, to understand how and for whom the intervention had such an effect.MethodForty women (index participants) who had recently screened for CC enrolled and were randomly assigned to receive the GC-CCP intervention (n = 20) or the wait-list control (n = 20). Up to three alters from each participant (n = 103) were surveyed at baseline and month 6. Measures of CC-related cognitive constructs (knowledge, enacted stigma, and risk management self-efficacy), as well as extent of advocacy received from index participants, were assessed as mediators of the intervention effect on alter advocacy using multivariate regression analyses. Alter characteristics were examined as moderators.ResultsIncreased CC-related knowledge partially mediated the intervention effect on increased alter engagement in CC prevention advocacy; those with greater gains in knowledge reported greater engagement in advocacy. No moderators of the intervention effect were identified.ConclusionThe effect of GC-CCP on alter CC prevention advocacy is enhanced by increased alter knowledge pertaining to CC prevention, causes, and treatment and suggests this may be key for diffusion of intervention effects on increased CC prevention advocacy throughout a social network.Trial RegistrationNCT04960748 (registered on clinicaltrials.gov, 7/14/2021).

2024-09-01·European Journal of Obstetrics & Gynecology and Reproductive Biology

Influence of women’s decision-making autonomy and partner support on adherence to the 8 antenatal care contact model in Eastern Uganda: A multicenter cross-sectional study

Article

作者: Nantale, Ritah ; Wani, Solomon ; Kasibante, Samuel ; Lee, Seungwon ; Marvin Kanyike, Andrew

OBJECTIVEMaternal and child health outcomes remain a challenge in Uganda. Antenatal care (ANC) is effective in mitigating pregnancy and childbirth risks. Women's decision-making autonomy and partner support are crucial for adherence to ANC contacts and better pregnancy outcomes. We assessed the impact of women's decision-making autonomy and partner support on adherence to the 8 + ANC contact schedule among post-partum mothers in Eastern Uganda.METHODSA multicenter cross-sectional study was conducted in four tertiary health facilities in Eastern Uganda, utilizing quantitative techniques to collect data from 1077 postnatal mothers. Eligible participants were those who had given birth within the previous 48 h and had documentation of ANC contacts from their pregnancy. Data was collected using structured questionnaires and analyzed using multivariable logistic regression to assess factors associated with adherence to the WHO-recommended 8 + ANC contacts.RESULTSMost women were aged 20-34 years (792; 73.5 %). Only 253 (23.5 %) women adhered to the 8 + ANC contacts. A significant proportion lacked decision-making autonomy (839; 77.9 %), and over half reported partner support (550; 51.2 %). Decision-making autonomy and partner support were significantly associated with adherence to the 8 + ANC contacts (aOR: 1.6, 95 % CI: 1.2 - 2.2, p = 0.005) and (aOR: 1.9, 95 % CI: 1.4 - 2.7, p < 0.001), respectively. Women with at least five children had lower adherence to the 8 + ANC contacts (aOR=0.4, 95 % CI: 0.2 - 0.7, p = 0.002).CONCLUSIONEmpowering women and engaging their partners can improve maternal health service utilization and increase ANC contact adherence, leading to better maternal and neonatal health outcomes.

100 项与 Busitema University 相关的药物交易

登录后查看更多信息

100 项与 Busitema University 相关的转化医学

登录后查看更多信息