A Study on Subjective Evaluation of Fatigue Tolerance in Mental Stress after Long-Term Intake of Supplements Containing Plasmalogen (HSOP; Hokkaido Scallop Oil Plasmalogen) - The intake of plasmalogen supplement.

开始日期2022-11-17

申办/合作机构

Nihon Pharmaceutical University

JPRN-UMIN000039279

/ CompletedN/AIIT

Survey on integrative medicine utilization and attitude in Japanese local government staffs for disease prevention and health promotion program - Survey on integrative medicine utilization in Japanese local governments

开始日期2020-01-21

申办/合作机构

Nihon Pharmaceutical University

[+1]

JPRN-UMIN000030644

/ CompletedN/AIIT

Survey on integrative medicine utilization of Taiwanese general people - Survey on integrative medicine utilization in Taiwan

开始日期2018-01-25

申办/合作机构

Nihon Pharmaceutical University

[+1]

100 项与 Nihon Pharmaceutical University 相关的临床结果

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0 项与 Nihon Pharmaceutical University 相关的专利（医药）

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732

项与 Nihon Pharmaceutical University 相关的文献（医药）

2025-07-01·Tetrahedron

Stereoselective synthesis of novel 4′-methylsulfanyl-pyrimidine ribonucleosides by means of nucleophilic substitution of the 4′-benzoyloxy leaving group

作者: Tanaka, Hiromichi ; Kumamoto, Hiroki ; Kimura, Yasuaki ; Haraguchi, Kazuhiro ; Abe, Hiroshi

A synthetic route for the novel nucleosides 4′-methylsulfanyluridine (20a) and -cytidine (26) has been developed.This route consists of two steps; 1) preparation of 4′-O-benzoyloxy-xylofuranosylnucleoside 13 through electrophilic iodo-benzoyloxylation to 4′,5′-unsaturated uracil nulesoside 9 and replacement of the iodo-substituent at the 5′-position with the benzoyloxy group, 2) nucleophilic substitution of 13 with Me₃SiSMe leading to the 4′-α-methylsulfanylnucleoside 14a stereoselectively.The possible reaction mechanism of the 5′-deoxy-5′-iodonucleosides 10a and 10b with AgOBz is discussed.The transformation of the xylofuranosyl moiety of 14a into the ribonucleoside 20a was performed on the basis of the ring-opening of the O²,2′-anhydronucleoside 24 with benzoate ion.In this study, 4′-methylsulfanylcytidine 26 was also synthesized.

2025-07-01·Bioorganic & Medicinal Chemistry

Oxidization synthesis and bioactivity study of tricyclic and tetracyclic genipin derivatives with collins reagent as anti-inflammatory agents

Article

作者: Huang, Guan-Jhong ; Zeng, Wei-Zheng ; Chung, Cheng-Yen ; Wong, Fung Fuh ; Cha, Chun-Han ; Arai, Ichiro ; Uramaru, Naoto

Tricyclic and tetracyclic genipin derivatives were investigated with variety of oxidized agents to give the corresponding oxidized genipin products with α,β-unsaturated aldehyde moiety. Based on the experimental results, Collins reagent (complex of chromium(VI) oxide withpyridine in CH₂Cl₂) was examined as the better favorable oxidized selective agent. On the other hand, the oxidized tricyclic and tetracyclic genipins were also evaluated for stability using UV-visible spectroscopy and tested for their effects on NO production in LPS-induced RAW 264.7 cells. Most of oxidized tricyclic and tetracyclic genipin aldehyde derivatives were substantiallyimproved ≥4.0-fold inhibiting activity than allyl alcoholic genipin starting materials. On the other hand, SAR study indicated oxidized compound 3g possessed the best inhibitory activity (IC₅₀ = 2.60 μM) in comparison with reference standard Celecoxib (IC₅₀ = 22.6 μM) and Indomethacin (IC₅₀ = 156 μM). Furthermore, potential compounds (IC₅₀ ≤ 10 μM) were also chosen for safety profile study and oxidized compounds 3a-j showed significant safety, except for compound 3f possessed the cell toxicity (12.5 μM). The mechanism of compound 3g in reducing cyclooxygenase-2 (COX-2) during inflammation was further demonstrated through Western blot analysis. To sum-up, the potential drug candidate 3g, significantly exhibited better anti-inflammatory effect than Indomethacin.

2025-05-01·Biomedicine & Pharmacotherapy

Chlorogenic acid attenuates 5-fluorouracil-induced intestinal mucositis in mice through SIRT1 signaling-mediated oxidative stress and inflammatory pathways

Article

作者: Huang, Guan-Jhong ; Jiang, Wen-Ping ; Itokazu, Nanae ; Lin, Che-Hsuan

Mucositis, a common side effect of the chemotherapeutic drug 5-Fluorouracil (5-FU), causes severe and aggravating effects on mucosal cells in the oral cavity and intestine. This study in mice aimed to assess the antioxidant, anti-inflammatory, and mucosal protective properties of chlorogenic acid in mitigating 5-FU-induced intestinal mucositis. To investigate these potential protective effects, we developed a mouse model by administering an initial intraperitoneal (i.p.) injection of 5-FU, followed by daily i.p. injections of chlorogenic acid (10 and 20 mg/kg) for 10 consecutive days. Chlorogenic acid mitigated intestinal histopathological damage, reduced proinflammatory mediators and malondialdehyde (MDA) levels, and increased the glutathione (GSH) level by 5-FU. Chlorogenic acid treatment led to a significant reduction in the expression of inflammation-related proteins decreased oxidative stress-related proteins and, attenuated the expression of apoptosis and autophagy-related proteins in small intestinal tissues. Additional investigations are necessary to verify our findings and enhance our comprehension of how SIRT1 inhibition (EX-527) counteracts the anti-inflammatory effects of chlorogenic acid in intestinal tissues. In conclusion, our mice study has shown that chlorogenic acid exerts its protective effects on 5-FU-induced intestinal tissue damage, by reducing oxidative stress and inflammation through the modulation of multiple signaling pathways, including the TLR4/NF-κB/MAPK, AMPK/ SIRT1, and PI3K/AKT axis. These findings highlight the potential of chlorogenic acid as a therapeutic agent for mucositis, given its anti-inflammatory and antioxidant properties.

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100 项与 Nihon Pharmaceutical University 相关的转化医学

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