Skinvisible, Inc.

Results Demonstrate Significant Transdermal Penetration of GLP-1 Receptor Agonists and CB-1 Receptor Antagonists Using Invisicare Technology LAS VEGAS, NV / ACCESSWIRE / July 9, 2024 / Skinvisible Pharmaceuticals, Inc. ("Skinvisible" or "the Company"), (OTCQB:SKVI), an innovative topical pharmaceutical research and development company, today announced exciting data demonstrating its transdermal delivery of obesity drugs (and other glucose- controlling drugs) including a GLP-1 agonist and CB-1 receptor antagonist delivered by its proprietary Invisicare® technology; a polymer delivery vehicle that does not require a patch or needles. The Company previously announced it has filed two provisional patent applications covering formulations that leverage Invisicare for the transdermal administration of obesity drugs and other glucose-controlling agents. The Company has been developing topical formulations to enable transdermal absorption of these drugs, allowing for sustained release into the bloodstream. The results are compelling: Franz Cell diffusion studies demonstrated up to 69% penetration over six hours for the GLP-1 drug tested; For the CB-1 antagonists formulated with Invisicare, a 62% penetration rate was achieved over the same time period; In addition to these high penetration rates, these studies demonstrate that Invisicare formulations have the ability to provide sustained drug delivery over time. Data showed an average drug release of approximately 10% per hour. Building on this breakthrough, Skinvisible is confident that its proprietary technology can be applied to a broader range of GLP-1 agonists and CB-1 receptor antagonists with a molecular mass that permits transdermal penetration. This development opens up exciting possibilities for expanding the company's portfolio of obesity-targeting formulations. "Our Invisicare technology has the potential to revolutionize how obesity drugs are administered," said Terry Howlett, Skinvisible's CEO. "We can deliver significant amounts of drug systemically, potentially avoiding the side effects of oral pills and injections and increase patient compliance." He explained, "Since pills must pass through the digestive system and liver first, much of the drug is metabolized before reaching its target and may lead to uncomfortable side-effects. Injections can be painful and lead to poor patient compliance. Our topical cream formulations offer a transdermal approach that circumvents first-pass metabolism and related challenges. Furthermore, these transdermal obesity treatments could serve effectively as a maintenance therapy." Skinvisible has pursued the obesity market due to the overwhelming increase in the need for obesity drugs and treatment options. According to a recent IQVIA report, the prevalence of obesity in the world is expected to be 25% of the population by 2035. In conjunction with the increase in obesity, the global obesity market is expected to reach $24 billion in 2023, and a staggering $131 billion by 2028. Skinvisible is actively seeking a strategic partnership with a pharmaceutical and/or biotech company to bring the first transdermal obesity therapies to market and to explore applications of its transdermal delivery platform across other disease areas. For more information on Skinvisible Pharmaceuticals, partnerships and investment opportunities, please visit or contact info@skinvisible.com. About Skinvisible Pharmaceuticals, Inc. Skinvisible Pharmaceuticals, a wholly-owned subsidiary of Skinvisible, Inc., is a pioneering research and development company specializing in licensing proprietary topical and transdermal formulations utilizing its patented polymer skin delivery system; Invisicare. This innovative technology provides life-cycle management and distinctive enhancements for both topical and transdermal delivery products. Invisicare formulated as a lotion or cream, effectively adheres active ingredients to the skin facilitating a controlled release of the active to and/or through the skin and into the blood stream over time. Skinvisible has recently developed formulations for the potential treatment of obesity, along with over forty dermatology related conditions including rare skin disorders. For further details, please visit . Forward-Looking Statements: This press release contains 'forward looking' statements within the meaning of Section 21A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and are subject to the safe harbors created thereby including with respect to the possible development of any such products, the acceptance of any such products in the market place, the size of any such markets, the ability of any product candidates to be approved by the U.S. Food and Drug Administration among others. Such statements involve certain risks and uncertainties associated with an emerging company. Actual results could differ materially from those projected in the forward-looking statements as a result of risk factors discussed in Skinvisible, Inc. reports on the U.S. Securities and Exchange Commission (including, but not limited to, a report on Form 10Q for the period ending March 31, 2024). ### Contacts: Strategic Partnerships: Doreen McMorran - doreen@invisicare.com Corporate Inquiries: info@skinvisible.com Office Number: 702-433-7154 (PST) SOURCE: Skinvisible, Inc. View the original press release on accesswire.com

Administration of GLP-1 Receptor Agonists and CB-1 Receptor Antagonists Enhanced by Invisicare Topical / Transdermal Delivery System LAS VEGAS, NV / ACCESSWIRE / May 29, 2024 / Skinvisible Pharmaceuticals, Inc. ("Skinvisible" or "the Company"), (OTCQB:SKVI), an innovative pharmaceutical research and development company, announced a major advancement in the battle against obesity. The Company has achieved a significant milestone by officially filing a provisional patent application covering formulations that leverage the Company's proprietary delivery technology Invisicare® for the transdermal administration of obesity drugs. Titled "Transdermal Delivery Composition for Delivery of CB-1 Receptor Antagonists and/or GLP-1 Receptor Agonists, and Method of Delivery," this patent filing ushers in a new era of efficient and convenient obesity drug delivery solutions. The patent application focuses on Invisicare; a patented transdermal delivery technology designed to incorporate CB-1 receptor antagonists and/or GPL-1 receptor agonists, two classes of drugs known for their potential in obesity management, into a lotion that is applied topically to the skin using a metered applicator. Studies have demonstrated the superior transdermal penetration and controlled release of other active compounds using Invisicare's innovative technology; with certain actives exhibiting up to a tenfold increase in transdermal delivery effectiveness. By utilizing Invisicare, Skinvisible aims to not only offer patients a convenient and effective alternative to traditional oral or injectable therapies but to also enhance drug efficacy and potentially significantly reduce side effects as transdermal delivery avoids first-pass metabolism. Additionally, for long-term treatment of obesity, a transdermal delivery system could feasibly provide a convenient method for administering maintenance doses of anti-obesity medications. The global obesity drug market is poised to exceed $30 billion by 2027, propelled by the escalating prevalence of obesity worldwide and the eagerly anticipated advent of revolutionary anti-obesity medications. Nonetheless, the impediment posed by needles and injections remains a formidable barrier to access and compliance. Skinvisible's proprietary transdermal delivery technology overcomes this obstacle, unlocking the full therapeutic potential of CB-1 and GLP-1 targeting drugs. "Our transdermal technology has the potential to revolutionize how obesity drugs are administered, granting patients access to potent weight loss medications through the ease and convenience of a metered dose of lotion simply applied to the skin," remarked Terry Howlett, CEO of Skinvisible Pharmaceuticals. "This needle-free approach holds immense promise in enhancing treatment adherence and broadening the accessibility of obesity therapies to countless individuals grappling with weight-related challenges." He added, "This groundbreaking patent application highlights our proficiency in transdermal delivery and underscores our commitment to leveraging this capability to reshape treatment standards." Skinvisible is actively pursuing strategic partnerships with pharmaceutical and/or biotech companies to facilitate the introduction of the first transdermal obesity therapies to market and to explore the application of its delivery platform across diverse disease domains. For more information on Skinvisible Pharmaceuticals, partnerships and investment opportunities, please visit or contact info@skinvisible.com. About Skinvisible Pharmaceuticals, Inc. Skinvisible Pharmaceuticals, a wholly-owned subsidiary of Skinvisible, Inc., is a pioneering research and development company specializing in licensing proprietary topical and transdermal formulations utilizing its patented polymer skin delivery system; Invisicare. This innovative technology provides life-cycle management and distinctive enhancements for both topical and transdermal delivery products. Invisicare formulated as a lotion or cream, effectively adheres active ingredients to the skin facilitating a controlled release of the active to and/or through the skin and into the blood stream over time. Skinvisible has recently developed formulations for the potential treatment of obesity, along with over forty dermatology related conditions including rare skin disorders. For further details, please visit . Forward-Looking Statements: This press release contains 'forward looking' statements within the meaning of Section 21A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and are subject to the safe harbors created thereby including with respect to the possible development of any such products, the acceptance of any such products in the market place, the size of any such markets, the ability of any product candidates to be approved by the U.S. Food and Drug Administration among others. Such statements involve certain risks and uncertainties associated with an emerging company. Actual results could differ materially from those projected in the forward-looking statements as a result of risk factors discussed in Skinvisible, Inc. reports on the U.S. Securities and Exchange Commission (including, but not limited to, a report on Form 10Q for the period ending March 31, 2024). ### Contacts: Strategic Partnerships: Doreen McMorran - doreen@invisicare.com Corporate Inquiries: info@skinvisible.com Office Number: 702-433-7154 (PST) SOURCE: Skinvisible, Inc. View the original press release on accesswire.com

LAS VEGAS, NV / ACCESSWIRE / February 14, 2024 / Skinvisible, Inc. ("Skinvisible") (OTCQB:SKVI) is excited to share a promising update on the ongoing clinical trials conducted by its licensee, Quoin Pharmaceuticals, Inc. ("Quoin") (NASDAQ:QNRX). The trials focus on the innovative formulation "QRX003," powered by Skinvisible's Invisicare® proprietary drug delivery technology, to address the challenges of Netherton Syndrome ("NS"). Netherton Syndrome is a hereditary disorder affecting the skin, hair and immune system, currently lacking an approved treatment or cure. The preliminary results and updates from Quoin's ongoing clinical studies, operating under an open Investigational New Drug (IND) application, indicate noteworthy progress: Positive Initial Data and Clean Safety Profile: The trials have demonstrated positive initial data and a clean safety profile, leading to the implementation of an optimization plan. Optimization Plan Implementation: Quoin has increased the size of both clinical trials significantly and adjusted dosing frequency to twice-daily from once-daily for both trials. Elimination of Lower Dose: In the blinded trial, a lower dose has been eliminated based on the positive outcomes observed. Protocol Amendments: Quoin's press release highlights protocol amendments aimed at enhancing the data set and potentially expediting regulatory approval. Quoin's CEO, Dr. Michael Myers, expressed enthusiasm about the optimization plan, stating, "Armed with positive initial data and a clean safety pro date, we believe that these protocol amendments could ultimately result in the generation of a highly compelling data set which could support regulatory filings and approval for QRX003 as the first treatment for this terrible disease." Terry Howlett, President and CEO of Skinvisible, commented on the encouraging results, emphasizing the potential FDA approval of QRX003 as a significant milestone in providing much-needed relief to Nethertons Syndrome patients, "These developments support Skinvisible's vision to develop effective topical therapeutics and is an important step that could lead to other formulas and indications receiving approval." The Company previously announced that QRX003, the first Invisicare® delivery technology product, has already received acceptance for an Investigational New Drug Application (IND) from the U.S. Food and Drug Administration (FDA). Quoin is actively working towards obtaining necessary FDA and other regulatory approvals for marketing the product in the United States and other countries. About QRX003: QRX003 is a topical lotion formulated with Invisicare®, a proprietary delivery technology, and contains a broad-spectrum serine protease inhibitor. Its mechanism of action mimics the function of the specific protein LEKTI, addressing excessive skin shedding in Netherton patients and strengthening the compromised skin barrier. Skinvisible is dedicated to advancing topical therapeutics, and the progress in QRX003's clinical trials aligns with the company's commitment to delivering effective treatments for underserved patient populations. About Quoin Pharmaceuticals Ltd. Quoin Pharmaceuticals Ltd. is an emerging specialty pharmaceutical company focused on developing and commercializing therapeutic products that treat rare and orphan diseases. We are committed to addressing unmet medical needs for patients, their families, communities and care teams. Quoin's innovative pipeline comprises three products in development that collectively have the potential to target a broad number of rare and orphan indications, including Netherton Syndrome, Peeling Skin Syndrome, Palmoplantar Keratoderma, Epidermolysis Bullosa and others. For more information, go to: . About Skinvisible Pharmaceuticals, Inc. Skinvisible Pharmaceuticals is a research and development company that licenses its proprietary formulations made with Invisicare®, its patented polymer delivery system that offers life-cycle management and unique enhancements for topical and transdermal delivered products. Invisicare holds active ingredients on the skin for extended periods of time, allowing for the controlled release of actives. As well, and if required, the Invisicare technology allows for a controlled transdermal release through the skin. For more information please visit . Forward-Looking Statements: This press release contains 'forward looking' statements within the meaning of Section 21A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, and are subject to the safe harbors created thereby including with respect to the possible development of any such products, the acceptance of any such products in the market place, the size of any such markets, the ability of any product candidates to be approved by the U.S. Food and Drug Administration among others. Such statements involve certain risks and uncertainties associated with an emerging company. Actual results could differ materially from those projected in the forward-looking statements as a result of risk factors discussed in Skinvisible, Inc. reports on the U.S. Securities and Exchange Commission (including, but not limited to, a report on Form 10Q for the period ending September 31, 2023). ### Contact: Doreen McMorran info@skinvisible.com PH: 702-433-7154 x 7 SOURCE: Skinvisible, Inc. View the original press release on accesswire.com