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更新于：2025-05-07

Ryazan State Medical University

更新于：2025-05-07

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项与 Ryazan State Medical University 相关的临床试验

NCT05304689

/ RecruitingN/AIIT

Analysis of the Interconnection Between the Quantitative Indicators Cytokines in the Oral Fluid and the Local Inflammatory Process at the Stage of Orthopedic Rehabilitation of Patients With Postoperative Jaw Defects.

The of study is to increase the effectiveness of orthopedic rehabilitation of patients with postoperative jaw defects using various types of replacement structures, taking into account the clinical and morphofunctional characteristics of oral tissues after surgery.

开始日期2023-11-01

申办/合作机构

Ryazan State Medical University

NCT05920226

/ Active, not recruitingN/AIIT

Myocardial Fibrosis in Patients With Permanent Pacemakers

Patients with cardiac pathology and arrhythmias including those who have indications for pacemakers implantation will be included in the study. We will determine the influence of pacemaker implantation with the localization of the ventricular electrode in the top of the right ventricle or the middle third of the right ventricle according to echocardiographic and electrocardiographic parameters, congestive heart failure progression, patients' quality of life and follow-up therapy of patients with identified myocardial fibrosis with existing pacemaker.
Study of changes in echocardiography, electrocardiography, myocardial fibrosis markers, the quality of life of patients will allow to choose the most optimal localization of the ventricular electrode during implantation of the permanent pacemakers system in order to improve the quality of life of the patients.

开始日期2023-07-01

申办/合作机构

Ryazan State Medical University

NCT05933720

/ RecruitingN/AIIT

Evaluation of the Efficacy and Safety of the Drug Based on Vascular Regulatory Polypeptides for the Treatment of Patients With Lower Extremity Atherosclerotic Arterial Occlusive Disease.

The study is aimed at assessing the role of the activity of markers of endothelial dysfunction (cytotoxic malonic aldehyde (MDA), angiotensin II, endothelial nitric oxide synthase (NO), endothelin-1, prostacyclin) in the systemic circulation in patients with lower extremity atherosclerotic arterial occlusive disease undergoing open reconstructive interventions.

开始日期2023-04-01

申办/合作机构

Ryazan State Medical University

100 项与 Ryazan State Medical University 相关的临床结果

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0 项与 Ryazan State Medical University 相关的专利（医药）

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468

项与 Ryazan State Medical University 相关的文献（医药）

2025-06-01·Psychiatry Research

Treatment and long-term outcome of mental disorders: The grim picture from a quasi-epidemiological investigation in 54,826 subjects from 40 countries

Article

作者: Lalljee, Alisha ; Pavlichenko, Alexey ; Muhammad, Nuru Suleiman ; Malik, Khamelia ; Bourgin-Duchesnay, Julie ; Matiekus, Eimantas ; Colon-Rivera, Hector ; Tsapakis, Eva Maria ; Elek, Livia Priyanka ; Popkov, Mikhail ; Iakimova, Rossitza ; Martínez, Xarah Elenne Meza ; Szczegielniak, Anna ; Panteleeva, Liliya ; Bukelskis, Laurynas ; Elissa, Anna ; Naor, Mika S ; Ignatenko, Yulia ; Stoyanova, Maria ; Nassieb, Amira ; De Lucena, David ; Dodd, Seetal ; Martinez, Stephanie ; Molina-López, Alejandro ; Hasan, Tasdik M ; Erdelyi-Hamza, Berta ; Shirasaka, Tomohiro ; Ibrahim, Mona ; Franza, Francesco ; García-Portilla, Maria Paz ; Rewekant, Anna ; Tavormina, Giuseppe ; Mejia, Gabriela ; Koh, Steve ; Bobes-Bascaran, Teresa ; Malashonkova, Evgeniia ; Crepin, Piirika ; Berk, Michael ; Vysotska, Olga ; Shah, Bhumika ; Ismail, Zaliha ; Vukovic, Olivera ; Rebok, Federico ; Hossain, Sahadat ; Yashikhina, Anna ; Hilbig, Jan ; Javed, Afzal ; Frias, Pedro ; Pandova, Milena ; Mammadzada, Gulay ; Tukhvatullina, Dina ; Papava, Ion ; Tamasan, Simona Claudia ; Hagin, Michal ; González, Daniela Morera ; Bobes, Julio ; Jakobs, Asaf ; Levaj, Sarah ; Mustač, Filip ; Tavormina, Maurilio Giuseppe Maria ; Malik, Najma Iqbal ; Saw, Jo Anne ; Mahalingappa, Sridevi Sira ; Alarcón, Renato D ; Memon, Roha Saeed ; Widiasih, Natalia ; Falkai, Peter ; Kafali, Helin Yilmaz ; Raduan, Nor Jannah Nasution ; Saiz, Pilar ; Jakovljević, Miro ; Smirnova, Daria ; Ahmed, Helal Uddin ; da Costa, Mariana Pinto ; Khalifa, Doaa ; Kosenko, Korneliia ; Ismayilova, Jamila ; Erzin, Gamze ; Vrublevska, Jelena ; Vadon, Nikolett Beata ; Mandalia, Bilvesh ; Marčinko, Darko ; Vega-Dienstmaier, Johann M ; Jakšić, Nenad ; Garay, Cristian J ; Gonda, Xenia ; Schneidereit, Patricia ; Navickas, Alvydas ; Skugarevsky, Oleg ; Mickevičiūtė, Dalia ; Arai, Kiyomi ; Marazziti, Donatella ; Milev, Roumen ; Mohammed, Muftau ; Liewig, Justine ; Majid, Abdul ; Grau, Arturo ; de Carmona, Manuel Sánchez ; Khaustova, Olena ; Kazakova, Olga ; Iftene, Felicia ; Etchevers, Martin J ; Pejuskovic, Bojana ; Ramírez, Francisca Vargas ; Garcia-Álvarez, Leticia ; Burkadze, Akaki ; Irarrazaval, Matias ; Spikina, Anna ; Flores, Elena Ninoska Reyes ; Okasha, Tarek ; Grandinetti, Paolo ; Auwal, Sani Salihu ; Fountoulakis, Konstantinos N ; Galako, Tatiana ; Filatova, Viktoriia ; De Berardis, Domenico ; Gould, Hilary ; Martínez, David Saucedo ; Kopishinskaia, Svetlana ; Harada, Takayuki ; Castilla-Puentes, Ruby ; Morozov, Petr ; Sitanggang, Satti ; Frankova, Iryna ; Fountoulakis, Nikolaos K ; Delgado, Sergio Zamora ; Groudeva, Violeta ; Ullah, Irfan ; Abud, Indira Indiana Cabrera ; De Sousa, Avinash ; Tohen, Mauricio ; Corral, Ricardo ; Karia, Sagar ; Panfil, Anca-Livia ; Razali, Salmi ; Cortez-Vergara, Carla ; Abraham, Seri ; Vaidya, Ratnaraj ; Rivera-Encinas, María Teresa ; Silagadze, Ketevan ; Saygili, Görkem ; Bredicean, Cristina Ana ; Popovic, Dina ; Farcas, Adriana ; Cetkovich, Marcelo ; Gondek, Tomasz M ; Rancans, Elmars ; Adorjan, Kristina ; Stefano, Ramona Di ; Karakatsoulis, Gregory ; Hashim, Nurul Azreen ; Fedotov, Ilya

INTRODUCTIONThis study registered rates of specific treatment options for mental disorders as well as their long-term outcome.MATERIAL AND METHODSThe history of mental disorders was used as a proxy for diagnosis. The data came from the COMET-G study (40 countries; 54,826 subjects, 64.73 % females, 35.45±13.51 years old). The analysis included descriptive statistics, Risk Ratios, t-tests, and ANCOVA's.RESULTS²⁴.14 % reported a history of any mental disorder (depression >12 %, non-affective psychosis and Bipolar disorder 1 % each, >20 % self-injury, >10 % had attempted suicide, 7.17 % illegal substance abuse). Most patients were not under any kind of treatment (59.44 %) and most were not receiving treatment as recommended (e.g. 90 % of Bipolar and 2/3 of psychotic patients). No treatment at all and psychotherapy as monotherapy were consistently related to poorer outcomes. In anxiety or depression, only antidepressant monotherapy and benzodiazepines, in Bipolar disorder only antipsychotic monotherapy in males and antidepressant monotherapy in females and in non-affective psychosis antipsychotics and psychotherapy in females only, were related to good outcomes. No treatment modality was related to a good outcome in those with a history of self-harm, suicidal attempts, or illegal substance use. Only depression and treatment with antidepressants were related to metabolic syndrome.DISCUSSIONIn the community, the overwhelming majority of mental patients do not receive appropriate treatment or, even worse, no treatment at all. The outcome is unfavourable for the majority and only a few selective treatment options seem to make a difference.

2025-02-28·Stomatology

On the issue of choosing anesthesia methods: a comparison of general medicine and clinical dentistry

Review

作者: Trusov, Yu.A. ; Ermakov, A.V. ; Khramova, M.A. ; Ustinova, E.A. ; Dubina, E.A.

A comparative analysis of the effectiveness of anesthesia methods used in general medicine and dentistry has been carried out. The study highlights various methods of anesthesia, including general, regional and local anesthesia, as well as innovative methods such as computer-based monitoring of the depth of anesthesia and the use of ultrasound to accurately administer the anesthetic. In dentistry, local anesthesia is more often used, which minimizes pain and has fewer side effects. One of the key issues in anesthesiology is the effectiveness of anesthesia, which depends on many factors, including the type of surgery, the physiological characteristics of the patient, and economic components. The main sources of information for this work were scientific articles published in peer-reviewed medical journals. The main platforms for finding relevant literature were: PubMed, ScienceDirect and Google Scholar.

2025-02-01·Biomeditsinskaya Khimiya

The inducing effect of S-nitrosoglutathione on the expression and activity of organic anion transporting polypeptide 1B1 (OATP1B1) in HepG2 cells

Article

作者: Shchul'kin, A.V. ; Myl'nikov, P.Yu. ; Suchkova, O.N. ; Gadzhiyeva, F.T. ; Kochanova, P.D. ; Abalenikhina, Yu.V. ; Uzbekov, M.G. ; Yakusheva, E.N.

The effect of the nitric oxide donor S-nitrosoglutathione on the level and activity of organic anion transporting polypeptide 1B1 (OATP1B1), as well as the expression of the SLCO1B1 gene encoding the transporter protein, was investigated in HepG2 cells. The study has shown that treatment of cells with S-nitrosoglutathione for 3 h did not influence the content and activity of OATP1B1. Incubation with S-nitrosoglutathione (10–500 μM) for 24 h increased SLCO1B1 expression, the content of OATP1B1, and activity of the transporter protein. Induction of the OATP1B1 protein by the NO donor was suppressed by the soluble guanylate cyclase (sGC) inhibitor, 10 μM ODQ (1H-[1,2,4]oxadiazolo-[4,3-a]quinoxaline-1-OH). Thus, the study has shown that S-nitrosoglutathione, acting through the NO-sGC-cGMP signaling pathway, increased SLCO1B1 gene expression, accompanied by the increase in the transporter protein content and its activity in cells.

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100 项与 Ryazan State Medical University 相关的转化医学

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