Ryazan State Medical University

更新于：2025-01-23

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NCT05304689

/ RecruitingN/AIIT

Analysis of the Interconnection Between the Quantitative Indicators Cytokines in the Oral Fluid and the Local Inflammatory Process at the Stage of Orthopedic Rehabilitation of Patients With Postoperative Jaw Defects.

The of study is to increase the effectiveness of orthopedic rehabilitation of patients with postoperative jaw defects using various types of replacement structures, taking into account the clinical and morphofunctional characteristics of oral tissues after surgery.

开始日期2023-11-01

申办/合作机构

Ryazan State Medical University

NCT05920226

/ Active, not recruitingN/AIIT

Myocardial Fibrosis in Patients With Permanent Pacemakers

Patients with cardiac pathology and arrhythmias including those who have indications for pacemakers implantation will be included in the study. We will determine the influence of pacemaker implantation with the localization of the ventricular electrode in the top of the right ventricle or the middle third of the right ventricle according to echocardiographic and electrocardiographic parameters, congestive heart failure progression, patients' quality of life and follow-up therapy of patients with identified myocardial fibrosis with existing pacemaker.
Study of changes in echocardiography, electrocardiography, myocardial fibrosis markers, the quality of life of patients will allow to choose the most optimal localization of the ventricular electrode during implantation of the permanent pacemakers system in order to improve the quality of life of the patients.

开始日期2023-07-01

申办/合作机构

Ryazan State Medical University

NCT06367166

/ Active, not recruitingN/AIIT

Study of the Effects of Bioflavonoids on Venous Wall Remodeling in Patients With Varicose Veins of the Lower Extremities

The study is aimed at assessing the dynamics of changes in biochemical markers of venous wall remodeling (type 1 plasminogen activation inhibitor (PAI-1), fibronectin (fibronectin, FN), vimentin (vimentin, VM), von Willebrand factor (vWF), PECAM-1 (CD31) ) in patients with C2s-C3s varicose veins compared with healthy volunteers while taking Venarus® (diosmin in combination with hesperidin).

开始日期2023-04-01

申办/合作机构

Ryazan State Medical University

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434

项与 Ryazan State Medical University 相关的文献（医药）

2024-09-30·Science. Culture. Society

Motivation for "tattoo" or what justifies the costs of self-expression of an individual

作者: Kroshilin, Sergey ; Medvedeva, Elena

The purpose of the article is to identify new trends in the perception of tattoos in modern society with an additional focus on analyzing the motives for making decisions about their application, including the financial aspect of the costs of this type of self-expression of an individual. The object of the study - dominant reasons/factors of tattooing in modern realities. Subject - modern trends in the perception of tattoos by different categories of working Russians with a focus on identifying contradictions between self-actualization through tattooing and emerging obstacles from society. The authors use analytical approaches and statistical methods of comparison in analyzing secondary and obtaining primary data on the studied problems. Data from the authors' 2023 surveys were used as primary data. The method of content analysis of statements during the thematic discussion on the portal of pedagogical community was also used. As the research has shown, the situation within society is ambiguous. A significant number of Russians are interested in self-expression through tattooing, but society still has a traditionally wary attitude towards tattoo wearers, especially those employed in social sectors. For tattoo wearers, regardless of their professional credentials, there are often significant barriers to employment and career advancement. Despite this, the study shows a growing trend in the number of tattoo wearers. Those who have already got them earlier are ready for further financial expenditures for renewal of old and application of new tattoos. The amount of money that respondents plan, want and can spend on tattooing, despite the difficult economic situation, reaches 100 thousand rubles. The results of the study can be practically significant for scientists, specialists, as well as researchers of consumer behavior of Russians from the point of view of economic aspects of decision-making on new types of goods and services and the formation of spending on self-expression.

2024-09-10·BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY

Variant anatomy of the facial innervation and the buccal fat pad in the maxillofacial region.

作者: Chilikov, Valerij ; Darawsheh, Hadi ; Yartseva, Aleksandra ; Zhandarov, Kirill Zhandarov ; Aleshkina, Olga ; Tiunova, Natalia ; Mirontsev, Artem ; Zhdanova, Maria ; Aymaletdinova, Zinaida ; Lopatin, Andrey ; Pavlov, Artem

Abstract The The questions of how an encapsulated, and therefore isolated, fat body can cross the branches of the facial nerve can be considered open. The goal was to study the variant anatomy of the syntopy of the branches of the facial nerve and the fatty body of the cheek. Anatomical material was collected from 2019 to 2022. The material for this study was 163 heads of adult men and women aged 46 to 94 years. Analysis of the significance of differences in groups was carried out using the methods of variation statistics in the licensed computer program “Statistica 6.0” (StatSoft, USA). 3 variants of the relationship of these anatomical structures were established and it is noteworthy that in 100% of observations the branches were represented by at least two trunks: 1 variant (37.42%; n=61) - the branches of the facial nerve pass directly along the surface of the buccal process of the fatty body of the cheek ; Option 2 (33.74% n=55) – the branches of the facial nerve pass along the upper and lower edges of the buccal process of the fat pad of the cheek; Option 3 (28.83%; n=47) – the branches of the facial nerve pass directly through the thickness of the buccal process of the buccal fat pad.

2024-09-01·Bulletin of Experimental Biology and Medicine

Regulation of the Organic Anion Transporting Polypeptide 1B3 (OATP1B3) by Sex Hormones

Article

作者: Abalenikhina, Yu V ; Shchulkin, A V ; Yakusheva, E N ; Slepnev, A A ; Ananyeva, P D

The mechanisms of regulation of the organic anion transporting polypeptide OATP1B3 by sex hormones were studied using HepG2 cells. Estradiol, progesterone, and testosterone were added to cells at concentrations of 1, 10, 100 μM for 24 h. The relative content of OATP1B3 was evaluated by Western blotting. Estradiol at concentrations of 10 and 100 μM increased the level of OATP1B3 acting through the farnesoid X-receptor, testosterone at concentrations of 1, 10, and 100 μM increased the expression of the transporter protein due to its effect on the liver X-receptor subtype α (LXRα), and progesterone did not affect the expression of OATP1B3.

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