更新于：2024-11-01

Ryazan State Medical University

更新于：2024-11-01

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项与 Ryazan State Medical University 相关的临床试验

NCT05304689 / RecruitingN/AIIT

Analysis of the Interconnection Between the Quantitative Indicators Cytokines in the Oral Fluid and the Local Inflammatory Process at the Stage of Orthopedic Rehabilitation of Patients With Postoperative Jaw Defects.

The of study is to increase the effectiveness of orthopedic rehabilitation of patients with postoperative jaw defects using various types of replacement structures, taking into account the clinical and morphofunctional characteristics of oral tissues after surgery.

开始日期2023-11-01

申办/合作机构

Ryazan State Medical University

NCT05920226 / Active, not recruitingN/AIIT

Myocardial Fibrosis in Patients With Permanent Pacemakers

Patients with cardiac pathology and arrhythmias including those who have indications for pacemakers implantation will be included in the study. We will determine the influence of pacemaker implantation with the localization of the ventricular electrode in the top of the right ventricle or the middle third of the right ventricle according to echocardiographic and electrocardiographic parameters, congestive heart failure progression, patients' quality of life and follow-up therapy of patients with identified myocardial fibrosis with existing pacemaker.
Study of changes in echocardiography, electrocardiography, myocardial fibrosis markers, the quality of life of patients will allow to choose the most optimal localization of the ventricular electrode during implantation of the permanent pacemakers system in order to improve the quality of life of the patients.

开始日期2023-07-01

申办/合作机构

Ryazan State Medical University

NCT06367166 / Active, not recruitingN/AIIT

Study of the Effects of Bioflavonoids on Venous Wall Remodeling in Patients With Varicose Veins of the Lower Extremities

The study is aimed at assessing the dynamics of changes in biochemical markers of venous wall remodeling (type 1 plasminogen activation inhibitor (PAI-1), fibronectin (fibronectin, FN), vimentin (vimentin, VM), von Willebrand factor (vWF), PECAM-1 (CD31) ) in patients with C2s-C3s varicose veins compared with healthy volunteers while taking Venarus® (diosmin in combination with hesperidin).

开始日期2023-04-01

申办/合作机构

Ryazan State Medical University

100 项与 Ryazan State Medical University 相关的临床结果

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0 项与 Ryazan State Medical University 相关的专利（医药）

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350

项与 Ryazan State Medical University 相关的文献（医药）

2024-09-10·BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY

Variant anatomy of the facial innervation and the buccal fat pad in the maxillofacial region.

作者: Yartseva, Aleksandra ; Darawsheh, Hadi ; Chilikov, Valerij ; Zhandarov, Kirill Zhandarov ; Aleshkina, Olga ; Tiunova, Natalia ; Mirontsev, Artem ; Zhdanova, Maria ; Aymaletdinova, Zinaida ; Lopatin, Andrey ; Pavlov, Artem

Abstract The The questions of how an encapsulated, and therefore isolated, fat body can cross the branches of the facial nerve can be considered open. The goal was to study the variant anatomy of the syntopy of the branches of the facial nerve and the fatty body of the cheek. Anatomical material was collected from 2019 to 2022. The material for this study was 163 heads of adult men and women aged 46 to 94 years. Analysis of the significance of differences in groups was carried out using the methods of variation statistics in the licensed computer program “Statistica 6.0” (StatSoft, USA). 3 variants of the relationship of these anatomical structures were established and it is noteworthy that in 100% of observations the branches were represented by at least two trunks: 1 variant (37.42%; n=61) - the branches of the facial nerve pass directly along the surface of the buccal process of the fatty body of the cheek ; Option 2 (33.74% n=55) – the branches of the facial nerve pass along the upper and lower edges of the buccal process of the fat pad of the cheek; Option 3 (28.83%; n=47) – the branches of the facial nerve pass directly through the thickness of the buccal process of the buccal fat pad.

2024-07-01·Biochemistry (Moscow)

Mechanism of Stimulation of Myogenesis under the Action of Succinic Acid through the Succinate Receptor SUCNR1

Article

作者: Yakusheva, Elena N. ; Abalenikhina, Yuliya V. ; Abalenikhina, Yuliya V ; Shchulkin, Alexey V. ; Mylnikov, Pavel Yu. ; Shchulkin, Alexey V ; Mylnikov, Pavel Yu ; Isayeva, Mariya O ; Isayeva, Mariya O. ; Yakusheva, Elena N

Effect of succinic acid on the processes of myogenesis was investigated in the study with the cells of C2C12 line. In the concentration range 10-1000 µM, succinic acid stimulated the process of myogenic differentiation, increasing the levels of myogenesis factors MyoD (at all stages of myogenesis) and myogenin (at the stage of terminal differentiation). Presence of the succinate receptors SUCNR1 was revealed in the C2C12 cells using Western blotting, level of which decreased during myogenesis. When succinic acid was added to the cells, the level of intracellular succinate did not change significantly and decreased during myogenic differentiation. Using a specific Gai protein inhibitor, pertussis toxin, it was found that stimulation of myogenesis in the C2C12 cells under the action of succinic acid is realized through SUCNR1-Gai interaction.

2024-06-01·Biomeditsinskaya Khimiya

The effect of lactoferin on the free radical and cytokine status of cornea in the experimental thermal burn

Article

作者: Kirsanova, I V ; Yakusheva, E N ; Erokhina, P D ; Abalenikhina, Yu V ; Shchulkin, A V ; Kolesnikov, A V

The free radical and cytokine statuses of the cornea during its thermal burn and the possibility of its correction by lactoferrin have been studied in Soviet Chinchilla rabbits. The development of a corneal thermal burn was accompanied by the development of oxidative stress (increased levels of TBA-reactive substances and carbonyl derivatives of proteins, decreased activity of SOD and GPx enzymes) and a pronounced inflammatory reaction with increased levels of TNF-1α, IL-10, TGF-1β. The use of lactoferrin had a pronounced therapeutic effect, which was manifested by accelerated healing, prevention of the development of complications (corneal perforations), a decrease in the severity of oxidative stress, an increase in the concentrations of TNF-1α (in the early stages), IL-10 (in the later stages), TGF-1β (throughout the experiment). At the same time, by the end of regeneration more severe corneal opacification was recognized compared to the control group. This may be associated with an increased level of anti-inflammatory cytokines, especially TGF-1β.

100 项与 Ryazan State Medical University 相关的药物交易

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100 项与 Ryazan State Medical University 相关的转化医学

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