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100 项与 Centre for Applied Microbiology & Research 相关的临床结果

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0 项与 Centre for Applied Microbiology & Research 相关的专利（医药）

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项与 Centre for Applied Microbiology & Research 相关的文献（医药）

2024-12-31·Green Chemistry Letters and Reviews

Valeriana jatamansi root extract a potent source for biosynthesis of silver nanoparticles and their biomedical applications, and photocatalytic decomposition

作者: Priyadharsan, Arumugam ; Manimaran, Kumar ; Ragavendran, Chinnasamy ; Kamaraj, Chinnaperumal ; Alharbi, Naify S ; Subramaniyan, Vetriselvan ; Naveenkumar, Selvam ; Thiruvengadam, Muthu ; Cherian, Tijo ; Sugumar, Vimal ; Rarokar, Nilesh ; Kumarasamy, Vinoth ; Prem, Pradisha

This study aimed to synthesize silver nanoparticles (VJ@AgNPs) using Valeriana jatamansi root extract and assess their antibacterial, antioxidant, and antibiofilm properties against Escherichia coli, Staphylococcus aureus, and Streptococcus mutans.Various chem. and phys. characterization methods were employed to analyze the synthesized VJ@AgNPs.UV-Visible spectroscopy confirmed the presence of VJ@AgNPs with a peak absorption at 426 nm, while FT-IR results indicated the involvement of phyto-compounds from V. jatamansi in the reduction and stabilization of these nanoparticles.High-resolution transmission electron microscopy revealed well-dispersed spherical nature with an average size of 29.1 ± 2.06 nm, and X-ray diffraction confirmed their crystalline structure.The biosynthesized VJ@AgNPs exhibited significant antibacterial activity against all tested pathogens, with substantial inhibition zones at 50 and 100μg/mL concentrationsAddnl., VJ@AgNPs displayed potent antibiofilm activity and antioxidant capacity in scavenging assays.Furthermore, these VJ@AgNPs showed promise in photocatalytic degradation, effectively removing 95% of RhB dye within 75 min under solar light irradiation, following pseudo-first-order kinetics.This suggests their potential application in wastewater treatment for organic dye removal.The biocompatible and environmentally friendly nature of VJ@AgNPs underscores their potential as therapeutic agents against bacterial infections and oxidative stress-related diseases.

2024-12-01·Bioresource Technology

Capability lignin from Acacia crassicarpa black liquor as an environmentally benign antibacterial agent to produce antibacterial and hydrophobic textiles

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作者: Nurfajrin Solihat, Nissa ; Zulfiana, Deni ; Oktaviani, Maulida ; Solihat, Nissa Nurfajrin ; Sarip Nawawi, Deded ; Nawawi, Deded Sarip ; Fatriasari, Widya ; Husna, Naurotul ; Purwanti, Try

Recently, the growing health awareness of society on the utilization of fabrics has led to an increasing demand for natural-based antibacterial textiles. Lignin, a generous polyphenol compound in nature, is capable of preventing bacterial growth; in particular, it dwells bacteria closely together on human skin, such as Staphylococcus epidermidis, Bacillus subtilis, Propionibacterium acnes, and Staphylococcus aureus. However, the antibacterial properties of lignin are limited by factors such as the lignin concentration, source, and type of bacteria. This study aimed to evaluate the potency of lignin as an antibacterial agent for textiles. Moreover, the thermal properties and wettability of the textile after lignin coating were also investigated. This study showed that lignin isolation methods significantly contributed to the inhibition of bacterial growth in the clear zone diameter. In addition, the lignin structure, lignin concentration, and type of bacteria had notably different antibacterial effects. SEM images showed that lignin was successfully coated on the fiber, and the antibacterial textile was successfully fabricated with clear zones in the range of 0.1-0.5 cm against four different bacteria. Lignin did not significantly improve the thermal stability of the textile, as proven by the TGA results. After the HDTMS coating by dispersion method, the wettability of the lignin-textile improved to that of the hydrophobic material, with a contact angle greater than 119.05° with excellent antibacterial properties (clear zone of 0.1-0.43 cm).

2024-12-01·Molecular Biology Reports

Expression of soluble moloney murine leukemia virus-reverse transcriptase in Escherichia coli BL21 star (DE3) using autoinduction system

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作者: Dewi, Kartika Sari ; Agustriana, Eva ; Purnawan, Awan ; Nuryana, Isa ; Laksmi, Fina Amreta ; Andriani, Ade ; Handayani, Christina Vivid ; Mubarik, Nisa Rachmania

Autoinduction systems in Escherichia coli can control the production of proteins without the addition of a particular inducer. In the present study, we optimized the heterologous expression of Moloney Murine Leukemia Virus derived Reverse Transcriptase (MMLV-RT) in E. coli. Among 4 autoinduction media, media Imperial College resulted the highest MMLV-RT overexpression in E. coli BL21 Star (DE3) with incubation time 96 h. The enzyme was produced most optimum in soluble fraction of lysate cells. The MMLV-RT was then purified using the Immobilized Metal Affinity Chromatography method and had specific activity of 629.4 U/mg. The system resulted lower specific activity and longer incubation of the enzyme than a classical Isopropyl ß-D-1-thiogalactopyranoside (IPTG)-induction system. However, the autoinduction resulted higher yield of the enzyme than the conventional induction (27.8%). Techno Economic Analysis revealed that this method could produce MMLV-RT using autoinduction at half the cost of MMLV-RT production by IPTG-induction. Bioprocessing techniques are necessary to conduct to obtain higher quality of MMLV-RT under autoinduction system.

100 项与 Centre for Applied Microbiology & Research 相关的药物交易

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100 项与 Centre for Applied Microbiology & Research 相关的转化医学

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