The goal of this clinical trial is to determine the effects of coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism in women with polycystic ovary syndrome. The main questions it aims to answer are:
Does Coenzyme Q10 alter oxidative stress, inflammation and hyperandrogenism in women with Polycystic ovary syndrome.
Participants will take Coenzyme Q10 200mg, once daily for a period of 3 months. The participants will be reassessed after 12 weeks by measuring Malondialdehyde MDA, C-reactive protein CRP, Sex hormone binding globulin SHBG.

开始日期2025-01-01

申办/合作机构

University of Faisalabad

[+1]

IRCT20240726062547N1 / RecruitingN/AIIT

Comparative effectiveness of Cranial Nerve Seventh (VII) Mobilization versus Manual Manipulation of facial muscles for improving muscular movement and Synkinesis among Bell’s palsy patients; Randomized Clinical Trial

开始日期2024-07-29

申办/合作机构

University of Faisalabad

IRCT20240508061706N1 / Recruiting临床3期IIT

Comparative effect of post Isometric Relaxation and Active Release Technique of calf muscles in young females

开始日期2024-05-31

申办/合作机构

University of Faisalabad

100 项与 University of Faisalabad 相关的临床结果

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0 项与 University of Faisalabad 相关的专利（医药）

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350

项与 University of Faisalabad 相关的文献（医药）

2024-11-01·Plant Physiology and Biochemistry

Empowering agriculture: The promise of zinc biofortification in rice

Review

作者: Jamal, Adil ; He, Shan ; Kallel, Mohamed ; Zubair, Akmal

Zinc (Zn) plays a crucial role in metabolism in both plant and animal life. Zn deficiency is a worldwide problem that has recently gotten worse. This micronutrient shortage can be largely attributed to eating foods that are poor in zinc. If biofortification methods were widely used, Zn enrichment of the organ or tissue of interest would increase dramatically. However, Zn absorption mechanisms in rice plants must be understood on a fundamental level before these methods can be used effectively. Plant systems' Zn transporters and metal chelators play a major role in regulating this intricate physiological characteristic. The Zn efficiency of specific species is affected by a variety of factors, including the plant's growth stage, edaphic conditions, the time of year, and more. Both old and new ways of breeding plants can be used for biofortification. We have highlighted the significance of recombinant and genetic approaches to biofortifying in rice. In this review, we have the metabolic role of zinc in rice, and the different transporter families involved in the transportation of zinc in rice. We have also discussed the combined approaches of agronomic and genetic in zinc biofortification in rice and potential outcomes and future predictions.

2024-10-03·Microbiology Spectrum

Characterization of differences in seed endophytic microbiome in conventional and organic rice by amplicon-based sequencing and culturing methods

Article

作者: Zhou, Xin-Gen ; Khanal, Sabin ; Imran, Muhammad ; Antony-Babu, Sanjay

ABSTRACT The seed serves as the primary source for establishing microbial populations in plants across subsequent generations, influencing plant growth and overall health. Cropping conditions, especially farming practices, can influence the composition and functionality of the seed microbiome. Very little is known about the differences in seed microbiome between organic and conventional production systems. In this study, we characterized the endophytic microbial populations in seeds of rice grown under organic and conventional management practices through culture-dependent and -independent analyses. The V4 region of 16S rRNA was used for bacterial taxa identification, and the ITS1 region was used for the identification of fungal taxa. Our results revealed significantly higher Shannon and Simpson indices for bacterial diversity in the conventional farming system, whereas the fungal diversity was higher for observed, Shannon, and Simpson indices in the organic farming system. The cultivable endophytic bacteria were isolated and identified using the full-length 16S rRNA gene. There was no difference in culturable endophytic bacterial isolates in rice seeds grown under both conventional and organic farming systems. Among 33 unique isolates tested in vitro , three bacteria— Bacillus sp. ST24, Burkholderia sp. OR5, and Pantoea sp. ST25—showed antagonistic activities against Marasmius graminum, Rhizoctonia solani AG4, and R. solani AG11, the fungal pathogens causing seedling blight in rice. IMPORTANCEIn this paper, we studied the differences in the endophytic microbial composition of rice seeds grown in conventional and organic farming systems. Our results demonstrate a greater bacterial diversity in conventional farming, while organic farming showcases a higher fungal diversity. Additionally, our research reveals the ability of seed bacterial endophytes to inhibit the growth of three fungal pathogens responsible for causing seedling blight in rice. This study provides valuable insights into the potential use of beneficial seed microbial endophytes for developing a novel microbiome-based strategy in the management of rice diseases. Such an approach has the potential to enhance overall plant health and improve crop productivity.

2024-10-01·Hepatology

Antagonistic effects of the cytotoxic molecules granzyme B and TRAIL in the immunopathogenesis of sclerosing cholangitis

Article

作者: Casar, Christian ; Javed, Sana ; Berkhout, Laura K. ; Neumann, Katrin ; Schwinge, Dorothee ; Krebs, Christian F. ; Will, Nico ; Kellerer, Mareike ; Schramm, Christoph ; Tiegs, Gisa

Background and Aims:Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by biliary inflammation and fibrosis. We showed an elevated interferon γ response in patients with primary sclerosing cholangitis and in multidrug resistance protein 2-deficient (Mdr2 −/− ) mice developing sclerosing cholangitis. Interferon γ induced expression of the cytotoxic molecules granzyme B (GzmB) and TRAIL in hepatic lymphocytes and mediated liver fibrosis in sclerosing cholangitis.Approach and Results:In patient samples and Mdr2 −/− mice, we identified lymphocyte clusters with a cytotoxic gene expression profile using single-cell RNA-seq and cellular indexing of transcriptomes and epitopes by sequencing analyses combined with multi-parameter flow cytometry. CD8+ T cells and NK cells showed increased expression of GzmB and TRAIL in sclerosing cholangitis. Depletion of CD8+ T cells ameliorated disease severity in Mdr2−/− mice. By using Mdr2−/− × Gzmb−/− and Mdr2−/− × Tnfsf10−/− mice, we investigated the significance of GzmB and TRAIL for disease progression in sclerosing cholangitis. Interestingly, the lack of GzmB resulted in reduced cholangiocyte apoptosis, liver injury, and fibrosis. In contrast, sclerosing cholangitis was aggravated in the absence of TRAIL. This correlated with elevated GzmB and interferon γ expression by CD8+ T cells and NK cells enhanced T-cell survival, and increased apoptosis and expansion of cholangiocytes.Conclusions:GzmB induces apoptosis and fibrosis in sclerosing cholangitis, whereas TRAIL regulates inflammatory and cytotoxic immune responses, subsequently leading to reduced liver injury and fibrosis.

100 项与 University of Faisalabad 相关的药物交易

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100 项与 University of Faisalabad 相关的转化医学

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