George Medicines UK Ltd.

George Medicines completes recruitment offirst Phase III hypertension trial investigating novel single-pill triple combination candidate GMRx2 All patients enrolled in active-controlled trial evaluating efficacy and safety of GMRx2 as treatment for hypertension including first line therapy Novel, patent-protected low and ultra-low dose formulations of GMRx2 are designed for optimal efficacy and safety, and to reach targeted blood pressure control across different patient types Second trial in Phase III programme, comparing GMRx2 against placebo, expands into new geographies, with both trials on track to report topline safety and efficacy data in Q4 2023 London, UK, 12July2023 – George Medicines, a late-stage drug development company transforming the management of cardiometabolic disease, today announced that all patients have been enrolled in its Phase III active-controlled trial evaluating the efficacy and safety of GMRx2, the Company’s lead pipeline candidate, as a treatment for hypertension including first-line therapy. More than 1,300 patients have been enrolled in the trial, across seven countries including the US, UK and Australia, comparing GMRx2, the Company’s proprietary single-pill, multi-mechanism, triple combination of telmisartan, amlodipine and indapamide – three existing, best-in-class treatments – with dual combinations of the same components. George Medicines’ mission is to extend and improve the lives of the millions of people suffering from non-communicable cardiometabolic diseases – the world’s leading causes of death and disability, including hypertension and diabetes. Its patent-protected, single-pill, multi-mechanism combinations of best-in-class, existing treatments in low and ultra-low doses, have the potential to reduce the impact of these diseases on patients, families, health systems and economies across the globe. Globally, over a billion people worldwide have hypertension but fewer than one in five have the condition under control. Individually, antihypertensive medicines are only modestly effective in reducing blood pressure, even at high doses, and most patients require two or more to achieve blood pressure control. GMRx2 is formulated in novel, patent-protected low and ultra-low doses, to be a simple, go-to solution to reach targeted blood pressure control across different patient types. Designed for optimal efficacy and safety, the synergistic and additive effects of its multiple mechanisms, in low doses, have the potential to be effective in a broad patient population, for use in earlier lines of treatment, and would avoid traditional escalation of testing and titrating multiple medicines. Daily dosing with just one pill also provides an opportunity to improve adherence. Dr. Karl Roberts, Chief Operating Officer of George Medicines, said:“The progress of this Phase III programmeis a huge testament to the dedication of the team and our partnersworking to bring GMRx2 to patients. There is an ambitious vision behind this combination candidate, to improve blood pressure control for patients globally, more quickly and without the tolerabilityand adherence challenges associated with currently available treatment options.Ahead of the programme’s data readoutanticipated later this year, we’re continuing our discussions with potential commercial partners for GMRx2 who share our belief in its potential and recognise the opportunity we have to transform how hypertension can be treated.” The Company also recently expanded its second trial in the GMRx2 Phase III programme, a placebo-controlled trial among 250 patients, into the UK, Nigeria and Sri Lanka. Already active in the US and Australia, in collaboration with global clinical research organisation George Clinical, this second trial is now actively recruiting patients further in Europe and into Africa and South Asia, in collaboration with the Imperial Clinical Trials Unit (ICTU) at Imperial College London and RemediumOne in Sri Lanka. Ends About George Medicines George Medicines is a late-stage drug development company with a mission to extend and improve the lives of millions of people suffering from non-communicable cardiometabolic diseases with patent-protected, low dose single-pills combinations of existing best-in-class medicines. These single-pill, multi-mechanism combinations offer the potential to bring significant improvements in clinical outcomes and therapy adherence in patients with non-communicable diseases (NCDs), including hypertension, diabetes and other common cardiometabolic disorders, each of which remain the leading causes of premature death and disability worldwide. The Company is building a strong and diversified pipeline with two lead product candidates in late-stage development. GMRx2, is in Phase III development for the treatment of hypertension including first line therapy and for the prevention of recurrent intracerebral haemorrhage (the most severe type of stroke); GMRx4 is in Phase II development for the treatment of type 2 diabetes. Further research programmes are underway in heart failure, coronary heart disease and chronic kidney disease. George Medicines is a spin-out company from The George Institute for Global Health, one of the world’s leading health research institutes for chronic disease. The Company is backed by George Health, the commercial arm of The George Institute, Brandon Capital, Australia’s leading life sciences venture capital firm supported by the Australian Government, BUPA and Federation Asset Management. For more information, please visit . Media contacts Consilium Strategic Communications David Daley, Lindsey Neville, Isabelle Abdou georgemedicines@consilium-comms.com Tel: +44 (0) 203 709 5700

Lindus Health will use their technology platform and machcine learning to manage trials from start to finish aiming to help treatments reach patients quickly in a bid to improve and extend lives. The news comes as the company reveals it has to date raised $6 million from investors, including from Firstminute, Seedcamp and Peter Thiel (PayPal co-founder and the first outside investor in Facebook), to accelerate their use of machine learning and data science to revolutionise clinical trials. Lindus Health is also announcing that it has received an Innovate UK Smart Grant, part of UK Research and Innovation (UKRI), worth almost £500,000, with their work in machine learning and data science described by UKRI assessors as a ‘​​hugely valuable and game-changing project’. Lindus Health says its technology speeds up the time it takes to approve treatments and get them to market, with their trials to date having been completed three times more quickly than the old-fashioned industry standard. Lindus has delivered more than 80 trials for treatments across the US, UK and Europe and will next be working with healthcare company, Pharmanovia, to evaluate the safety and efficacy of a treatment for patients with severe insomnia in a real-world setting. It will use digital technology to find hard-to-reach insomnia patients. Working with Oto, a provider of digital tinnitus programs, the company will run a trial for 200 people evaluating their digital tinnitus solution against in-person therapy. googletag.cmd.push(function () { googletag.display('text-ad1'); }); Additionally, Lindus is partnering with Berlin-based start-up Dopavision to trial the MyopiaX treatment for children affected by progressive short sightedness. This aims to increase dopamine levels in the retina to slow the progression of the condition. This year, Lindus Health is also launching a trial aimed at treating and reversing type 2 diabetes with George Medicines and a trial aimed at reducing symptoms of menopause, with US-based Bonafide Health, whose parent company is JDS Therapeutics. Launched in 2021 by Michael Young and Meri Beckwith, Lindus Health has already worked with 20,000 patients to find new treatments for chronic conditions. Co-founder of Lindus Health, Michael Young, said: “Clinical trials are the biggest bottleneck to improving human health. We’re working with high-growth companies developing the next wave of breakthrough treatments to accelerate the clinical trials process. “It’s fantastic to be working with the Government and industry pioneers to revolutionise clinical trials to deliver treatments to benefit patients more quickly. “From monitoring trial data in real time to using machine learning to predict trial outcomes and make improvements to trial designs in advance, we want to simplify and accelerate the trials process and put patients first.”

FRANKFURT AM MAIN, Germany--( BUSINESS WIRE )-- As of immediately, Stefan König will be responsible for Merz Therapeutics GmbH as CEO and Managing Director. As one of the businesses of Merz Group, Merz Therapeutics provides medical solutions for the treatment of serious health conditions such as neurological health impairments or diseases of the liver. Stefan König is an accomplished leader who has successfully worked in the pharmaceutical industry for his entire career, both at national and international market level. “Merz Therapeutics has had a successful development in last years. That is why we are very pleased to have won an exceptional executive with Stefan König who will continue to expand our business and take it to the next level. His profound expert knowledge in both clinical-stage drug development and commercialization as well as his experience in different global markets make him the ideal person to drive the future growth strategy of Merz Therapeutics,” says Phillip Burchard, CEO of the Merz Group and Chairman of the Merz Holding Board. Until recently, Stefan König held the position of President and CEO of George Medicines, a London-based company focusing on the development of pharmaceuticals in an advanced clinical phase. George Medicines is a spin-off of the George Institute, one of the leading international health research institutes. Before this, Stefan König worked for many years at Takeda Pharmaceuticals, where he held various senior positions in global, regional and local functions. Among others, he was responsible for the global Inflammatory Bowel Disease franchise, after heading up a number of local and regional market organizations. After a strategic reorganization three years ago, Merz Group created Merz Therapeutics as one of its three core businesses, with the goal for each of the individual businesses to have a better focus on specific customers and markets. Since then, Merz Therapeutics has developed favourably. The previous CEO and Managing Director of Merz Therapeutics, Stefan Brinkmann, is leaving Merz by best mutual agreement at the end of February after many years. With Stefan König’s appointment as of March 1, 2023, we will ensure a seamless transition. About the Merz Group The Merz Group is a global, diversified health care company based in Frankfurt, Germany. Family-owned for over 110 years, the company is distinguished by its commitment to innovation, a long-term perspective, and a focus on sustainable, profitable growth. The Merz Group includes the businesses Merz Aesthetics, Merz Therapeutics, Merz Consumer Care, Merz Real Estate, and Merz Financial Investments. The company employs 3,730 people (as of financial year 21/22) in 28 countries worldwide. To learn more, please visit www.merz.com