The stability of Shenmai injections with different solubilizer and explore a solubilizer for replacing polysorbate 80 was investigated.Shenmai injection was prepared with 15-hydroxy polyethylene glycol stearate (0.2%) and polysorbate 80 (0.5%) as solubilizer, resp.With appearance, insoluble particles, visible particles, fingerprint similarity, pH and content of ginsenosides as indexes, stability of Shenmai injections was investigated, including influencing factor test (lighting, high temperature, low temperature, freezing and thawing), long-term stability test in 25 degree C and acceleration test in 40 degree C.UV was adopted to determine content of total saponins with detection wavelength at 544 nm; the content of ginsenosides was determined by HPLC, mobile phase of acetonitrile (A)-water (B) for gradient elution (0-30 min, 0%-10%A; 30-40 min, 10%-23%A; 40-50 min, 23%A; 50-85 min, 23%-60%A; 85-95 min, 60%-100%A) and detection wavelength at 203 nm.Appearance, insoluble particles and visible particles of Shenmai injections with different solubilizer were in line with regulations, fingerprint similarity was 0.98, and the content of ginsenosides had no significant difference.Compared with polysorbate 80, 15-hydroxy polyethylene glycol stearate had the same solubilization effect, and prepared Shenmei injections had good stability.