Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego PAN (Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego PAN)

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疾病领域	数量

感染	1

排名前五的药物类型	数量

适配体	1

关联

1

项与 Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego PAN 相关的药物

APTA-1

靶点-

作用机制

免疫刺激剂

在研机构

Institute of Hematology & Blood Transfusion [+3]

原研机构

Aptahem AB

在研适应症

脓毒症 [+1]

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

首次获批日期-

100 项与 Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego PAN 相关的临床结果

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0 项与 Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego PAN 相关的专利（医药）

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4,953

项与 Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego PAN 相关的文献（医药）

2025-01-01·Behavioural Brain Research

Cortical high-frequency oscillations (≈ 110 Hz) in cats are state-dependent and enhanced by a subanesthetic dose of ketamine

Review

作者: González, Joaquín ; Pascovich, Claudia ; Castro-Zaballa, Santiago ; Mateos, Diego ; Tort, Adriano ; Cavelli, Matías ; Torterolo, Pablo ; Hunt, Mark Jeremy

Ketamine is an NMDA receptor antagonist that has antidepressant and anesthetic properties. At subanesthetic doses, ketamine induces transient psychosis in humans, and is used to model psychosis in experimental animals. In rodents, subanesthetic doses of ketamine increase the power of high-frequency oscillations (HFO, > 100 Hz) in the electroencephalogram (EEG), a frequency band linked to cognitive functions. However, to date, the effects of ketamine in carnivores and primates have been poorly investigated. Here, we examined in the cat, cortical HFO during wakefulness, sleep, and after administering a sub-anesthetic dose of ketamine. Four cats were prepared with cortical electrodes for chronic polysomnographic recordings in head-restrained conditions. The cortical HFO power, connectivity, direction of the information flow using Granger Causality (GC) analysis, their relationships with respiratory activity, and the effect of auditory stimulation were analyzed. During wakefulness, but not during sleep, we found that HFO were coupled with the inspiratory phase of the respiration. After ketamine administration, HFO power was enhanced and remained associated with the inspiratory phase. GC analysis suggests that ketamine-enhanced HFO originate from the olfactory bulb (OB) and stream towards the prefrontal cortex (Pf). Accordingly, occluding the nostrils significantly reduced the power of the ketamine-enhanced HFO in both the OB and Pf. Finally, auditory stimulation did not affect HFO. In conclusion, the HFO are associated with respiration during wakefulness, but not during sleep. The enhancement of this rhythm by ketamine may disrupt cortical information processing, which could contribute to some of the neuropsychiatric effects associated with ketamine.

2024-12-31·RNA Biology

Multiple roles for AU-rich RNA binding proteins in the development of haematologic malignancies and their resistance to chemotherapy

Review

作者: Podszywalow-Bartnicka, Paulina ; Neugebauer, Karla M

Post-transcriptional regulation by RNA binding proteins can determine gene expression levels and drive changes in cancer cell proteomes. Identifying mechanisms of protein-RNA binding, including preferred sequence motifs bound in vivo, provides insights into protein-RNA networks and how they impact mRNA structure, function, and stability. In this review, we will focus on proteins that bind to AU-rich elements (AREs) in nascent or mature mRNA where they play roles in response to stresses encountered by cancer cells. ARE-binding proteins (ARE-BPs) specifically impact alternative splicing, stability, decay and translation, and formation of RNA-rich biomolecular condensates like cytoplasmic stress granules (SGs). For example, recent findings highlight the role of ARE-BPs - like TIAR and HUR - in chemotherapy resistance and in translational regulation of mRNAs encoding pro-inflammatory cytokines. We will discuss emerging evidence that different modes of ARE-BP activity impact leukaemia and lymphoma development, progression, adaptation to microenvironment and chemotherapy resistance.

2024-12-01·Mechanisms of Ageing and Development

Development and validation of cardiometabolic risk predictive models based on LDL oxidation and candidate geromarkers from the MARK-AGE data

Article

作者: Grubeck-Loebenstein, Beatrix ; Gradinaru, Daniela ; Weber, Daniela ; Weinberger, Birgit ; Garagnani, Paolo ; Capri, Miriam ; Frank, Jan ; Grune, Tilman ; Valeanu, Andrei ; Sikora, Ewa ; Bacalini, Maria Giulia ; Hervonen, Antti ; Bürkle, Alexander ; Gonos, Efstathios S ; Margina, Denisa ; Stuetz, Wolfgang ; Breusing, Nicolle ; Toussaint, Olivier ; Franceschi, Claudio ; Slagboom, P Eline ; Debacq-Chainiaux, Florence ; Talbot, Duncan ; Fiegl, Simone ; Jansen, Eugène HJM ; Pirazzini, Chiara ; Dollé, Martijn E T ; Mosieniak, Grazyna ; Moreno-Villanueva, María ; Jansen, Eugène Hjm ; Bernhardt, Jürgen

The predictive value of the susceptibility to oxidation of LDL particles (LDLox) in cardiometabolic risk assessment is incompletely understood. The main objective of the current study was to assess its relationship with other relevant biomarkers and cardiometabolic risk factors from MARK-AGE data. A cross-sectional observational study was carried out on 1089 subjects (528 men and 561 women), aged 40-75 years old, randomly recruited age- and sex-stratified individuals from the general population. A correlation analysis exploring the relationships between LDLox and relevant biomarkers was undertaken, as well as the development and validation of several machine learning algorithms, for estimating the risk of the combined status of high blood pressure and obesity for the MARK-AGE subjects. The machine learning models yielded Area Under the Receiver Operating Characteristic Curve Score ranging 0.783-0.839 for the internal validation, while the external validation resulted in an Under the Receiver Operating Characteristic Curve Score between 0.648 and 0.787, with the variables based on LDLox reaching significant importance within the obtained predictions. The current study offers novel insights regarding the combined effects of LDL oxidation and other ageing markers on cardiometabolic risk. Future studies might be extended on larger patient cohorts, in order to obtain reproducible clinical assessment models.

100 项与 Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego PAN 相关的药物交易

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100 项与 Instytut Biologii Doswiadczalnej im. Marcelego Nenckiego PAN 相关的转化医学

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