4区 · 医学
Article
作者: Czaplewski, Lloyd G. ; Collins, Ian ; Boyd, E. Andrew ; Brown, David ; East, Stephen P. ; Gardiner, Mihaly ; Fletcher, Rowena ; Haydon, David J. ; Henstock, Vincent ; Ingram, Peter ; Jones, Clare ; Noula, Caterina ; Kennison, Leanne ; Rockley, Chris ; Rose, Valerie ; Thomaides-Brears, Helena B. ; Ure, Rebecca ; Whittaker, Mark ; Stokes, Neil R.
3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.