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项与 Ichor Biologics LLC 相关的药物

JL-16

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安第斯汉坦病毒糖蛋白

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安第斯汉坦病毒糖蛋白抑制剂

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原研机构

Ichor Biologics LLC初创企业 [+1]

在研适应症-

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汉坦病毒感染

最高研发阶段无进展

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MIB-22

靶点

安第斯汉坦病毒糖蛋白

作用机制

安第斯汉坦病毒糖蛋白抑制剂

在研机构-

原研机构

Ichor Biologics LLC初创企业 [+1]

在研适应症-

非在研适应症

汉坦病毒感染

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Ichor Biologics LLC 相关的临床结果

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0 项与 Ichor Biologics LLC 相关的专利（医药）

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8

项与 Ichor Biologics LLC 相关的文献（医药）

2022-05-01·Cell Reports

IgG targeting distinct seasonal coronavirus- conserved SARS-CoV-2 spike subdomains correlates with differential COVID-19 disease outcomes

Article

作者: Alvarez, Raymond A ; Bravo, Felipe ; Bowman, James W ; Garrido, Jose L ; Pinos, Yazmin ; Bahl, Christopher D ; Calvo, Mario ; McGee, Sarah ; Brachman, Rebecca A ; Barria, Maria Ines ; Medina, Matías A ; Fuentes-Villalobos, Francisco

Despite SARS-CoV-2 being a "novel" virus, early detection of anti-spike IgG in severe COVID-19 patients may be caused by the amplification of humoral memory responses against seasonal coronaviruses. Here, we examine this phenomenon by characterizing anti-spike IgG responses in non-hospitalized convalescent individuals across a spectrum of COVID-19 severity. We observe that disease severity positively correlates with anti-spike IgG levels, IgG cross-reactivity against other betacoronaviruses (β-CoVs), and FcγR activation. Analysis of IgG targeting β-CoV-conserved and non-conserved immunodominant epitopes within the SARS-CoV-2 spike protein revealed epitope-specific relationships: IgG targeting the conserved heptad repeat (HR) 2 region significantly correlates with milder disease, while targeting the conserved S2'FP region correlates with more severe disease. Furthermore, a lower HR2-to-S2'FP IgG-binding ratio correlates with greater disease severity, with ICU-hospitalized COVID-19 patients showing the lowest HR2/S2'FP ratios. These findings suggest that HR2/S2'FP IgG profiles may predict disease severity and offer insight into protective versus deleterious humoral recall responses.

2018-11-21·Science Translational Medicine1区 · 医学

Two recombinant human monoclonal antibodies that protect against lethal Andes hantavirus infection in vivo

1区 · 医学

Article

作者: Rioseco, Maria L. ; Barria, Maria I. ; Riquelme, Raul ; Prescott, Joseph ; Alvarez, Raymond ; Garrido, Jose L. ; Bravo, Felipe ; Feldmann, Heinz ; Haddock, Elaine ; Williamson, Brandi N. ; Calvo, Mario ; Salas, Alexis

Post-exposure highly potent human monoclonal antibodies target Andes hantavirus glycoprotein in a hamster hantavirus cardiopulmonary syndrome model.

bioRxiv

Humoral immune responses against seasonal coronaviruses predict efficiency of SARS-CoV-2 spike targeting, FcγR activation, and corresponding COVID-19 disease severity

作者: Bahl, Christopher D. ; Alvarez, Raymond A. ; Calvo, Mario ; Bowman, James W. ; Brachman, Rebecca A. ; McGee, Sarah ; Fuentes, Francisco ; Bravo, Felipe ; Barria, Maria Ines ; Medina, Matias ; Garrido, Jose L.

Despite SARS-CoV-2 being a "novel" coronavirus, several studies suggest that detection of anti-spike IgG early in infection may be attributable to the amplification of humoral memory responses against seasonal hCoVs in severe COVID-19 patients.In this study, we examined this concept by characterizing anti-spike IgG from a cohort of non-hospitalized convalescent individuals with a spectrum of COVID-19 severity.We observed that anti-spike IgG levels pos. correlated with disease severity, higher IgG cross-reactivity against betacoronaviruses (SARS-CoV-1 and OC43), and higher levels of proinflammatory Fc gamma receptor 2a and 3a (FcγR2a & FcγR3a) activation.In examining the levels of IgG targeting betacoronavirus conserved and immunodominant epitopes vs. disease severity, we observed a pos. correlation with the levels of IgG targeting the conserved S2'FP region, and an inverse correlation with two conserved epitopes around the heptad repeat (HR) 2 region.In comparing the levels of IgG targeting non-conserved epitopes, we observed that only one of three non-conserved immunodominant epitopes correlated with disease severity.Notably, the levels of IgG targeting the receptor binding domain (RBD) were inversely correlated with severity.Importantly, targeting of the RBD and HR2 regions have both been shown to mediate SARS-CoV-2 neutralization.These findings show that, aside from antibody (Ab) targeting of the RBD region, humoral memory responses against seasonal betacoronaviruses are potentially an important factor in dictating COVID-19 severity, with anti-HR2-dominant Ab profiles representing protective memory responses, while an anti-S2'FP dominant Ab profiles indicate deleterious recall responses.Though these profiles are masked in whole antigen profiling, these analyses suggest that distinct Ab memory responses are detectable with epitope targeting anal.These findings have important implications for predicting severity of SARS-CoV-2 infections (primary and reinfections), and may predict vaccine efficacy in subpopulations with different dominant antibody epitope profiles.

100 项与 Ichor Biologics LLC 相关的药物交易

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100 项与 Ichor Biologics LLC 相关的转化医学

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