Horizon Immobilien GmbH

Volunteers were given metaclazepam (I) [84031-17-4] (0-40 mg/kg) with EtOH [64-17-5] (0-1.25 g/kg) in order to determine if any drug-drug interaction exists with regard to psychophys. performance.The large standard deviations in the results make the findings difficult to interpret.However, it seems that the interaction between I and EtOH is additive rather than synergistic or antagonistic.

Phys. and chem. properties of HCFC 142 b, toxicity after single and long-term exposures, mutagenicity, genetic toxicity and carcinogenicity, skin and eye irritation, cardiovascular effects and kinetics and metabolism are described.

Investigations show that Al(OH)₃ which has been ignited at 1200-1350° is still hygroscopic, therefore, analysis for Al content by the usual determination of impurities and ignition is subject to error.Ignition at 1500° or above (30 min. is sufficient), followed by cooling over P₂O₅ in a desiccator gives a product of constant weightAt the usual ignition temperature, however, special precautions, such as immediate transfer of the hot material to a ground-glass-closed tube, must be observed if the most accurate results are desired.Exposure for only 15 min. on a balance resulted in the following weight increases for Al₂O₃ ignited 30 min. at 1200°: 4.5 mg. sample, 16.0% increase, 8.5 mg., 12.8% increase, and 18.7 mg., 5.5% increase.Titrations for water content by the Fischer method confirmed these observations.With the Brunauer-Emmett-Teller method for N adsorption, the surface available for adsorption in Al₂O₃ ignited at different temperatures was calculated, typically, as: 1000°, 126 sq. m./g.; 1250°, 8.3; 1350°, 6.7; and 1500°, 3.8.Above 1300° sintered corundum was preferable to Pt as a crucible material, since Pt showed a weight change.