A cross-sectional study representative of the Polish population of children aged 5 months to 6 years conducted in the cross-sectional study model, the main objective of which is to assess the nutritional value of the diet of children aged from 5 months to 6 years with regard to the basic macronutrients: protein (P), fat (F), carbohydrates (C). The study will include: dietary interviews, which will include the Food Frequency Questionnaire questionnaire (FFQ) and a 3-day food diary, as well as anthropometric measurements. The study will involve 1,000 children who will be selected by a random draw based on government database. The survey will be conducted by trained field interviewers - training will be provided by a dietician and an anthropologist. The study also included validation of the FFQ questionnaire.

开始日期2024-06-01

申办/合作机构

Institute of Mother & Child

NCT05968768 / Recruiting临床2期IIT

To Evaluate the Efficacy and Safety of Naxitamab in Patients With Refractory Ewing's Sarcoma

Prospective, interventional, open, randomized, national, multicenter, non-commercial trial

开始日期2023-10-24

申办/合作机构

Institute of Mother & Child

[+1]

EUCTR2022-003812-98-PL / Not yet recruiting临床2期IIT

To evaluate the efficacy and safety of naxitamab in patients with refractory Ewing's sarcoma.

开始日期2023-04-04

申办/合作机构

Institute of Mother & Child

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924

项与 Institute of Mother & Child 相关的文献（医药）

2024-12-31·European Journal of General Practice

Follow-up of patients with chronic conditions within primary care practices during COVID-19: Results from 7 Central and Eastern-European countries from the cross-sectional PRICOV-19 study

Article

作者: Torzsa, Peter ; Prytherch, Helen ; Tkachenko, Victoria ; Collins, Claire ; Windak, Adam ; Curochicin, Ghenadie ; Busneag, Carmen ; Van Poel, Esther ; Curteanu, Ala ; Willems, Sara ; Asenova, Radost ; Rotaru, Cristina ; Seifert, Bohumil ; Schindler, Christian ; Delvento, Giulia

BACKGROUNDThe COVID-19 pandemic posed severe challenges to delivery of services at Primary Care level and for achieving follow-up of patients with chronic diseases.OBJECTIVESWe analysed data from the PRICOV-19 study to explore determinants of active follow-up for chronic disease patients in seven Central and Eastern European (CEE) countries during the pandemic.METHODSPricov-19 was a cross-sectional study conducted within PC (Primary Care) practices in 37 European countries. We analysed data from 7 CEE countries (Bulgaria, Czech Republic, Hungary, Poland, Moldova, Romania, Ukraine) collected between November 2020 and December 2021. Practices were recruited through random or convenience sampling and participation of practices was voluntary. We performed descriptive statistics to identify the level of follow-up of chronic disease and what health system and practice-specific factors were associated with better follow-up. We used logistic regression and meta-analysis techniques to explore associations and heterogeneity between countries.RESULTS67.8% out of 978 practices reported actively following up chronic patients. Positive associations were found between active follow-up and such as having more GPs (aOR = 1.18, p-value = 0.005), an above-average chronic patient population (aOR = 3.13, p-value = 0.006), adequate government support (aOR = 2.35, p-value = 0.001), and GPs having time for guideline reading (aOR = 0.008, p-value = 1.71).CONCLUSIONSPatient follow-up, was influenced by different health system and practice-specific factors. The implications suggest the need for government support to enhance PC practice organisation during crises and solutions to decrease GP workload and provide tailored care for patients with chronic disease.

2024-09-01·Journal of Perinatology

Prenatal ultrasound markers for prediction of complex gastroschisis—single-center retrospective cohort study

Article

作者: Jaczyńska, Renata ; Nimer, Anna ; Sawicka, Ewa ; Mikulska, Boyana ; Mydlak, Dariusz ; Maciejewski, Tomasz

OBJECTIVETo evaluate prenatal ultrasound markers for distinguishing simple gastroschisis (sGS) from complex gastroschisis (cGS) and identifying fetuses at risk of complications.STUDY DESIGNA retrospective cohort study analyzed 61 fetuses with isolated gastroschisis at a tertiary center from 2011 to 2021, utilizing serial ultrasounds from 14 to 35 weeks' gestation. A general linear model, quantile regression, and logistic regression assessed ultrasound markers, fetal weeks, and gastroschisis risk, yielding predictive models.RESULTSIABL dilatation showed the highest PPV but low NPV. Non-free floating bowel loops (NFFBL) indicated the best PPV to NPV ratio. Combinations of markers yielded the highest predictive value for cGS. EABL collapsed and non-free floating bowel loops were significant, consistent risk factors.CONCLUSIONSPrenatal ultrasounds can predict cGS risk, particularly using IABL dilatation and NFFBL as markers. Accurate assessment requires considering gestational age, qualitative symptoms, emphasizing experienced perinatologists' role and monitoring, particularly after 30 weeks of gestation.

2024-09-01·Journal of Neural Transmission

Differential diagnosis of Huntington’s disease− neurological aspects of NKX2-1-related disorders

Review

作者: Milanowski, Łukasz ; Nowicki, Maciej ; Sławek, Jarosław ; Koziorowski, Dariusz ; Dulski, Jarosław ; Sharif, Lucia ; Skwara, Julia ; Skrzypek, Katarzyna ; Hoffman-Zacharska, Dorota ; Elert-Dobkowska, Ewelina

AbstractBenign hereditary chorea (BHC) is an inherited neurological disorder consisting of childhood-onset, nonprogressive chorea, generally without any other manifestations. In most reported cases, the inheritance of BHC is autosomal dominant but both incomplete penetrance and variable expressivity are observed and can be caused by NKX2-1 mutations. The spectrum contains choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress syndrome. The neurological symptoms can be misdiagnosed as Huntington’s disease (HD). The two Polish families were diagnosed with NKX2-1 gene mutations and a literature review concerning the NKX2-1-related disorders was conducted. All family members were examined by experienced movement disorders specialists. PubMed database was searched to obtain previously described NKX2-1 cases. Whole exome sequencing (WES) was performed in one proband (Family A) and direct NKX2-1 sequencing in the second (Family B). Two Polish families were diagnosed with NKX2-1 gene mutations (p.Trp208Leu and p.Cys117Alafs*8). In one family, the co-occurrence of HD was reported. Forty-nine publications were included in the literature review and symptoms of 195 patients with confirmed NKX2-1 mutation were analyzed. The most common symptoms were chorea and choreiform movements, and delayed motor milestones. The NKX2-1 mutation should always be considered as a potential diagnosis in families with chorea, even with a family history of HD. Lack of chorea does not exclude the NKX2-1-related disorders.

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