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项与 Josai University 相关的药物

MGM-9

靶点

κ opioid receptor x μ opioid receptor

作用机制

κ opioid receptor激动剂 [+1]

在研机构-

原研机构

Josai University

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最高研发阶段无进展

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6

项与 Josai University 相关的临床试验

JPRN-UMIN000053031

/ CompletedN/AIIT

Investigation of marathon-induced muscle damage - Investigation of marathon-induced muscle damage

开始日期2023-10-01

申办/合作机构

Josai University

JPRN-UMIN000050724

/ RecruitingN/AIIT

Effects of Chocolate Rich in Oleic Acid and Flavanols on Energy Metabolism - Effects of Chocolate Rich in Oleic Acid and Flavanols on Energy Metabolism

开始日期2023-03-15

申办/合作机构

Josai University

JPRN-UMIN000050722

/ RecruitingN/AIIT

A study of the relationship between energy metabolism and blood and urine metabolits - A study of the relationship between energy metabolism and blood and urine metabolits

开始日期2022-10-10

申办/合作机构

Josai University

100 项与 Josai University 相关的临床结果

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0 项与 Josai University 相关的专利（医药）

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3,732

项与 Josai University 相关的文献（医药）

2025-04-02·Crystal Growth & Design

Lanthanide-Based Single-Molecule Magnets Derived from Lacunary Polyoxometalates

作者: Hayami, Shinya ; Zenno, Hikaru ; Sekine, Yoshihiro ; Kobayashi, Fumiya ; Hirakawa, Kenta ; Horii, Yoji ; Nakaya, Manabu

Toward the development of new functional materials with single-mol. magnet (SMM) behavior, novel lacunary Dawson-type polyoxometalate (POM)-based clusters containing lanthanide ions (Dy³⁺ and Tb³⁺) were synthesized and their applicability as SMMs was verified.Four discrete complexes were obtained at a mixing ratio of lanthanide ions to lacunary POM clusters of 2:2 or 1:2, yielding K₁₄[Dy₂(P₂W₁₇O₆₁)₂]·52H₂O (1), K₁₇[Dy(P₂W₁₇O₆₁)₂]·52H₂O (2), K₁₄[Tb₂(P₂W₁₇O₆₁)₂]·52H₂O (3), and K₁₇[Tb(P₂W₁₇O₆₁)₂]·53H₂O (4), which were characterized by single-crystal X-ray structural anal.Detailed measurements of the a.c. (ac) magnetic properties revealed that 1 and 2 exhibited the SMM behavior (U_eff/k_B = 2.19 and 22.23 K, τ₀ = 9.02 x 10^-7 and 4.56 x 10^-5 s, H_dc = 3000 and 1000 Oe, resp.), unlike 3 and 4.The distorted geometry of Dy³⁺ ions in 2 in relation to that in 1 resulted in slow magnetic relaxation caused by SMMs with larger energy barrier values, according to temperature-dependent ac susceptibility measurements and theor. calculationsTherefore, new hybrid materials as SMMs from trivalent lanthanide ions and lacunary POM clusters can be fabricated.This study opens new avenues for constructing next-generation compounds that exhibit interesting slow magnetic relaxation based on the assembly of lanthanide ions and lacunary POMs.

2025-04-01·Chemical and Pharmaceutical Bulletin

Hyaluronan Tetrasaccharides Penetrate into the Skin by Passive Diffusion and Contribute to Skin Health

Review

作者: Takagi, Yutaka ; Kage, Madoka

Hyaluronan (HA) is a commonly used material in cosmetics and pharmaceuticals because of its various pharmacological activities. However, because of its large molecular weight, HA penetrates the skin very poorly and most of it remains on the skin surface. Thus, topically applied HA could not be expected to function biologically in the skin. However, we have confirmed that HA tetrasaccharides (HA4), which is the smallest unit of HA, penetrate into the skin by passive diffusion and affect epidermal metabolism. Topical treatment of HA4 rescues the epidermal damage caused by long-term UVA irradiation. Furthermore, various biological functions of HA4 to maintain healthy skin was observed in cell culture studies. This review describes the skin permeability of HA4 and how it contributes to healthy skin.

2025-04-01·International Journal of Oral and Maxillofacial Surgery

Postoperative maxillary stability after Le Fort I osteotomy using a u-HA/PLLA system: three-dimensional analysis by surface superimposition based on virtual Le Fort I osteotomy

Article

作者: Maeda, K. ; Maeda, K ; Yamamoto, S. ; Taniike, N. ; Taniike, N ; Iwadate, R ; Iwadate, R. ; Yamamoto, S

The postoperative stability achieved with Le Fort I osteotomy (LFI) using bioabsorbable systems remains controversial. A new method - multipoint measurement method - was devised for detailed three-dimensional examination of postoperative stability following LFI, and the stability after LFI when using SuperFIXSORB-MX made of u-HA/PLLA was investigated. Thirty-one patients who underwent LFI using SuperFIXSORB-MX were evaluated retrospectively. The patients were divided into four malocclusion types: open bite, mandibular retrognathia, mandibular protrusion, and facial asymmetry. Seven maxillary reference points were measured three-dimensionally using computed tomography scans obtained preoperatively (T0), 4 days post-surgery (T1), and 1 year post-surgery (T2). Surgical changes (T1-T0) and the postoperative discrepancy (T2-T1) of the maxilla were analysed to evaluate postoperative stability by surface superimposition of the virtual LFI segments. Postoperative discrepancy was the largest for the facial asymmetry type, ranging from 0.75 ± 0.45 mm to 0.98 ± 0.52 mm in three-dimensional distance (minimum to maximum mean ± standard deviation values for the individual reference points). The relapse at U1 was 16% in the transverse axis, and the anterior nasal spine moved further upward by 17% of the amount of movement of the maxilla. Fixation with SuperFIXSORB-MX was considered to be within clinically acceptable limits.

100 项与 Josai University 相关的药物交易

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100 项与 Josai University 相关的转化医学

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