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项与 Japan Bio Products Co., Ltd. 相关的临床试验

Effect of a horse placental extract-containing cream on the wrinkles in the corner of the eyes of healthy women: a single-blind, comparison study - Anti-wrinkle function evaluation test of a horse placental extract-containing eye cream

开始日期2021-12-16

申办/合作机构

Japan Bio Products Co., Ltd.

JPRN-UMIN000042240 / CompletedN/A

A clinical study of the efficacy and safety of placenta extract in elderly people with low muscle strength and gait speed -Open label trial- - A research of placenta extract in elderly people with low muscle strength and gait speed

开始日期2017-08-28

申办/合作机构

Japan Bio Products Co., Ltd.

100 项与 Japan Bio Products Co., Ltd. 相关的临床结果

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0 项与 Japan Bio Products Co., Ltd. 相关的专利（医药）

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28

项与 Japan Bio Products Co., Ltd. 相关的文献（医药）

2023-05-01·Open veterinary journal

Successful steroid tapering and partial treatment of suspected immune-mediated haemolytic anaemia in a dog with equine placenta extract supplementation: A case report.

作者: Kotoku, Sachiko ; Hirano, Eiichi ; Tahara, Kentarou

BackgroundWe report on the clinical management and outcome of an 11-year-old dog diagnosed with suspected refractory immune-mediated anemia (IMHA) and treated with equine placental extract supplementation.Case DescriptionThe patient had received standard treatment with subcutaneous infusion of prednisone (2 mg/kg) and oral administration (1.3 mg/kg semel in die [sid]), with limited success as hematocrit (HCT) values continued to fall rapidly, and the patient continued to have severe symptoms of fatigue. The patient was then put on equine placental extract supplements, after which the patient's physical exhaustion was improved, and although the HCT level initially continued to fall, it eventually began to rise and remained near normal for approximately 2 years. A significant reduction in prednisone use was achieved with placental supplementation.ConclusionEquine placental supplementation may be useful as a new complementary therapy for suspected refractory IMHA.

2022-01-01·Open Veterinary Journal

Successful treatment of ascites accumulation and diarrhea associated with protein-losing enteropathy with oral equine placenta extract supplementation in a dog: A case report

作者: Watanabe, Tsuyuko ; Fukushima, Naoki ; Hirano, Eiichi ; Tahara, Kentarou ; Kakehi, Nobuhisa

Background: Protein-losing enteropathy (PLE) is characterized by leakage of serum proteins into the intestinal lumen, indicating hypoproteinemia. Immunosuppressive agents are the mainstay of treatment, but in many cases, patients are forced to taper off early owing to the induction of liver damage. Case Description: An 8-year-old, unneutered female Chihuahua presented with diarrhea and ascites effusion lasting 2 weeks. Based on the results of radiography and blood tests, a diagnosis of PLE was made. Prednisolone (3 mg/kg semel in die [SID]) and MitoMax (200 mg/day) were administered, but ascites accumulation and diarrhea did not improve. Thus, azathioprine (2 mg/kg/day) was added, but there was no improvement and liver damage developed. The liver injury did not improve immediately, but the diarrhea and ascites effusion improved after serum total protein and serum albumin levels increased after they had decreased. Subsequent tapering of prednisolone from 3 mg/kg SID to 1 mg/kg SID, combined with MitoMax (200 mg/day) and equine placenta extract (eqPE) (2 mL/day), resulted in no recurrence of ascites or diarrhea. Conclusion: In canine PLE with prolonged diarrhea and ascites effusion, supplementation with eqPE may be considered as a reasonable additional therapeutic strategy.

2021-12-01·BMC Research Notes

Placental extract suppresses the formation of fibrotic deposits by tumor necrosis factor alpha and transforming growth factor beta-induced epithelial–mesenchymal transition in ARPE-19 cells

Article

作者: Sugimoto, Koji ; Igarashi, Kyoko ; Hirano, Eiichi

AbstractObjectiveEpithelial–mesenchymal transition (EMT) is involved in the development of proliferative vitreoretinopathy (PVR) and subsequent fibrosis. Previously, we demonstrated that placental extract ameliorates fibrosis in a mouse model of non-alcoholic steatohepatitis. In this study, we evaluated whether placental extract influences EMT and fibrosis through cytokine-induced EMT in the retinal pigment epithelial cells, in vitro.ResultsPlacental extract did not inhibit EMT, but it suppressed excessive mesenchymal reactions and the subsequent fibrosis. These results suggest that placental extract effectively ameliorates EMT-associated fibrosis in PVR. This beneficial effect could be partially attributed to the suppression of excessive mesenchymal reactions.

100 项与 Japan Bio Products Co., Ltd. 相关的药物交易

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100 项与 Japan Bio Products Co., Ltd. 相关的转化医学

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