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概览

疾病领域	数量

感染	2

排名前五的药物类型	数量

单克隆抗体	2

排名前五的靶点	数量

hemagglutinin(血凝素)	2

关联

5

项与 Rotta Research Laboratorium Spa 相关的药物

PN-SIA 28 (Fides)

靶点

hemagglutinin

作用机制

hemagglutinin调节剂

在研机构

Fides Sa

原研机构

Pomona Ricerca Srl

在研适应症

甲型流感病毒感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

PN-SIA 49 (Fides)

靶点

hemagglutinin

作用机制

hemagglutinin调节剂

在研机构

Fides Sa

原研机构

Pomona Ricerca Srl

在研适应症

甲型流感病毒感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

CR-2622

靶点

CCKB

作用机制

CCKB拮抗剂

在研机构-

原研机构

Rottapharm SpA

在研适应症-

非在研适应症

焦虑症

最高研发阶段终止

首次获批国家/地区-

首次获批日期-

100 项与 Rotta Research Laboratorium Spa 相关的临床结果

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0 项与 Rotta Research Laboratorium Spa 相关的专利（医药）

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58

项与 Rotta Research Laboratorium Spa 相关的文献（医药）

2000-01-01·Naunyn-Schmiedeberg's Archives of Pharmacology4区 · 医学

Cholecystokinin (CCK) increases GABA release in the rat anterior nucleus accumbens via CCKB receptors located on glutamatergic interneurons

4区 · 医学

Article

作者: Lanza, Marco ; Makovec, Francesco

The effects of cholecystokinin sulfate octapeptide (CCK-8S) on [3H]gamma-aminobutyric acid (GABA) release have been studied in the anterior side of the rat nucleus accumbens on tissue punches exposed in superfusion to 30 mM KCl. CCK-8S in a concentration dependent manner (10-3000 nM) increased K+-evoked [3H]GABA release (EC50=192 nM). The increase caused by 1 microM CCK-8S ranged from 37% to 42%. CR 2945, (beta-[2-[[2-(8-azaspiro[4.5]dec-8-ylcarbonyl)-4,6-dimethylp henyl]-amino]-2-oxoethyl]-(R)-1-naphthalenepropanoic acid), a potent and selective nonpeptidergic CCK(B) antagonist, concentration-dependently blocked CCK-8S effect (IC50=2.16 nM). CCK-8S-induced increase in [3H]GABA overflow was completely blocked by 1 microM tetrodotoxin. Both the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) and the N-methyl-D-aspartic acid (NMDA) receptor antagonist dizocilpine (MK-801) antagonized the CCK-8S effect. By contrast, (+)-bicuculline, a GABA(A) receptor antagonist, was completely ineffective. Phaclofen, a selective GABA(B) antagonist, increased K+-evoked [3H]GABA release but did not affect the facilitative effect of CCK-8S. Moreover, tetrodotoxin failed to block AMPA-evoked [3H]GABA release but completely prevented the effect of NMDA (Mg2+ free conditions). The data presented suggest that CCK(B) receptors modulating [3H]GABA release from anterior accumbal punches may not be present on GABAergic terminals but could be located on glutamatergic interneurons.

1999-12-01·American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans

Article

作者: Rovati, Lucio ; Matzinger, Daniel ; Orban, Amar ; Drewe, Juergen ; Engel, Reto ; Beglinger, Christoph ; D'Amato, Massimo ; Gutzwiller, Jean-Pierre

Intraduodenal fat inhibits gastric emptying and exerts early satiation in animals and humans, but it is not clear whether the effects are mediated by cholecystokinin (CCK) in humans. Here, we tested whether CCK-A receptors mediate the inhibition of fat on food intake. Two sequential, double-blind, crossover studies were performed in 24 male subjects. First, subjects received either intraduodenal fat or saline together with a preload of either water or banana shake. Second, 12 subjects received either intraduodenal fat or saline perfusion plus a concomitant infusion of saline or loxiglumide, a specific CCK-A receptor antagonist, together with a preload of banana shake. In both studies, subjects were free to eat and drink as much as they wished. Fat induced a reduction in calorie intake ( P < 0.05) compared with controls. Furthermore, a decrease in hunger feelings was observed. Infusion of loxiglumide abolished the effects of fat. Duodenal fat interacts with an appetizer to modulate energy intake in humans. This effect is mediated by CCK-A receptors.

1999-04-01·American Journal of Physiology-Heart and Circulatory Physiology

Physiological doses of estradiol decrease nocturnal blood pressure in normotensive postmenopausal women

Article

作者: Malmusi, Stefania ; Rovati, Lucio ; Zanni, Annalisa ; Cagnacci, Angelo ; Facchinetti, Fabio ; Volpe, Annibale

The effect of a 2-mo treatment with transdermal estradiol (50 μg/day) versus placebo on 24 h of blood pressure rhythm was investigated in 18 normotensive healthy postmenopausal women. Whereas daytime blood pressure was not modified, nighttime blood pressure was reduced by estradiol. Estradiol magnified the nocturnal decrement of systolic (14.3 ± 7.2 vs. 9.8 ± 6.7 mmHg, P = 0.0033), diastolic (11.6 ± 5.0 vs. 7.5 ± 7.3 mmHg, P = 0.028), and mean (10.8 ± 5.6 vs. 7.2 ± 4.5 mmHg, P = 0.011) blood pressure. As a consequence, the 24-h rhythm of mean blood pressure was restored in 50% of the subjects ( P = 0.045) in whom it was absent and was amplified in the remaining 50% of the subjects. Body mass index was an independent determinant of blood pressure values being directly related to the amplitude of the 24-h mean blood pressure rhythm ( r2= 0.38; P = 0.0067). In normotensive postmenopausal women, physiological doses of estradiol amplify the nocturnal decline of blood pressure.

100 项与 Rotta Research Laboratorium Spa 相关的药物交易

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100 项与 Rotta Research Laboratorium Spa 相关的转化医学

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管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床前

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其他

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当前项目

药物(靶点)	适应症	全球最高研发状态

PN-SIA 28 (Fides) ( hemagglutinin )	甲型流感病毒感染更多	临床前
PN-SIA 49 (Fides) ( hemagglutinin )	甲型流感病毒感染更多	临床前
CR-2345 ( CCK receptor )	胃溃疡更多	无进展
CR-2471/P	心绞痛更多	无进展
CR-2622 ( CCKB )	焦虑症更多	无进展