The goals of this study is to evaluate the feasibility and the effects of a WhatsApp-assisted prehabilitation for colorectal cancer patients undergoing elective surgery. The main questions are: If the digital prehabilitation is feasible and acceptable by the colorectal cancer patient prior to elective surgery? If this prehabilitation helps to improve the postoperative complications, length of stay, physical activity and psychological well-being for colorectal cancer patients receiving surgery.
Researcher will compare the prehabilitation plus standard care to standard care only to see if the prehabiliation helps the colorectal cancer patients.
Participants will: 1) enrolled in a approximate 4 weeks (3 episodes/ week) prehabilitation program containing educational information of colorectal cancer, dietary advice, exercises training and psychological podcasting. 2) will answer the survey weekly and after surgery. 3) keep the standard care as per department guidelines

开始日期2026-01-15

申办/合作机构

將軍澳醫院

[+1]

ChiCTR2500110717

/ Not yet recruitingN/AIIT

WhatsApp-assisted prehabilitation programme for adult patient undergoing elective colorectal cancer surgery

开始日期2025-09-10

申办/合作机构

香港中文大学

[+1]

NCT06225765

/ RecruitingN/AIIT

A Prospective Trial Comparing Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA) and Conventional Open Thyroidectomy

To determine if transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a safe and effective procedure compared to traditional open thyroidectomy. Surgical outcomes, patients' satisfaction, voice and swallowing outcomes will be assessed.

开始日期2024-07-01

申办/合作机构

將軍澳醫院

100 项与將軍澳醫院相关的临床结果

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194

项与將軍澳醫院相关的文献（医药）

2026-01-01·AMERICAN JOURNAL OF OPHTHALMOLOGY

International Consensuses and Guidelines on the Etiology, Diagnosis and Management of Intraocular Foreign Bodies (IOFBs) by the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO), the Asia-Pacific Vitreo-retina Society (APVRS), and the Academia Retina Internationalis (ARI)

Article

作者: Wong, Daniel H T ; Chen, Haoyu ; Das, Taraprasad ; Mieler, William F ; Lim, Jennifer I ; Yan, Hua ; Lam, Dennis S C ; Caputo, Georges ; Lou, Bingsheng ; Au, Andrea C K ; Li, Kenneth K W ; Justin, Grant A ; Ruamviboonsuk, Paisan ; Zhang, Feng ; Watson, Stephanie ; Yu, Seung-Young ; Lee, Eun Kyoung ; Lai, Chi-Chun ; Choovuthayakorn, Janejit ; Azad, Rajvardhan ; Huang, Xin ; Radke, Nishant V ; Agrawal, Rupesh ; Fong, Kenneth

PURPOSE:

To discuss the critical aspects and establish a consensus among experts regarding intraocular foreign bodies (IOFB) management, and to standardize clinical management for IOFB cases in order to ensure consistent and optimal clinical outcomes.

DESIGN:

A modified Delphi method to reach a consensus among international experts.

METHODS:

An expert panel was formed by the Academy of Asia-Pacific Professors of Ophthalmology (AAPPO), the Asia-Pacific Vitreo-retina Society (APVRS), and the Academia Retina Internationalis (ARI) to identify the controversy and establish consensus and statement on the management of IOFB. The core group of the panel gathered, reviewed, discussed, and formulated the statements. The statements were rated by the expert panel based on a five-point Likert scale (strongly agree, agree, neutral, disagree and strongly disagree). A consensus was reached when at least 75% of the experts voted either "agree" or "strongly agree" for a statement.

RESULTS:

Twenty four international experts from 11 countries/territories participated. Fifty four consensus statements were reviewed in the following 8 sections: diagnostic controversies, ⁠⁠IOFB characterization controversies, management controversies, prophylactic measures controversies, post-extraction management controversies, special population considerations, outcomes assessment controversies, and future directions. The expert panel showed good agreement in all sections. Consensus was reached for 49 out of 54 statements, while the final score was less than 75% for 5 statements.

CONCLUSION:

The strong majority of consensus statements serves as a useful guidance, enabling clinicians to approach IOFB removal in a systemic manner with more confidence and improve patient outcomes. The varying levels of agreement in some statements underscore remaining uncertainties in IOFB clinical management.

2025-10-01·RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

PHYSICAL FACTORS INFLUENCING THE COMPLETENESS OF REMOVAL OF RESIDUAL PERFLUOROCARBON LIQUID IN VITREORETINAL SURGERY

Article

作者: Chen, Ying ; Steel, David H. ; Guo, Wei ; Chu, Wang Yee ; Chan, Yau Kei ; Lau, Chun Wai Maggie ; Long, Zhongdui ; Li, Kenneth Kai Wang

Purpose::

Postoperative perfluorocarbon liquid (PFCL) retention would lead to serious complications, especially retinal toxicity and intraocular inflammation. This study aimed to elucidate the roles of air infusion pressure and residual balanced salt solution in PFCL evaporation during vitreoretinal surgery, thereby optimizing residual PFCL removal, minimizing complications, and improving patient outcomes.

Methods::

Evaporation rates of perfluoro-n-octane and perfluoro-decalin were studied using a 3D-printed eye model under varying air infusion pressures from 10 to 40 mmHg. Computational fluid dynamics simulations were used to qualitatively capture PFCL evaporation dynamics, followed by interpretation with a quantitative mathematical model, which also elucidates the impact of the balanced salt solution film on PFCL evaporation.

Results::

In the 3D-printed eye model, PFCL completely evaporated at rates of 1.03 µL/second (perfluoro-n-octane) and 0.28 µL/second (perfluoro-decalin) at an air pressure of 30 mmHg. Perfluorocarbon liquid evaporation rate increased almost linearly from 10 to 30 mmHg (P < 0.05) before reaching its maximum level. Computational fluid dynamics simulations revealed enhanced PFCL evaporation rate as air pressure rises. A mathematical model, based on inlet air pressure enhanced PFCL vapor diffusion, was derived to quantitatively capture PFCL evaporation under clinical conditions with balanced salt solution.

Conclusion::

Both in vitro experiments and mathematical models indicate that trace amounts of PFCL could evaporate completely under surgically representative air pressure levels without significantly extending surgical time. Inlet air pressure significantly accelerates PFCL vapor diffusion rate, dominating PFCL evaporation. The height of the balanced salt solution film exerts a determinant effect on the evaporation of PFCL even under the surgically relevant air infusion pressure level.

2025-10-01·PHYTOMEDICINE

Parthenolide inhibits Hsp90α ATPase activity and overcomes acquired BRAF-inhibitor resistance in cutaneous melanoma

Article

作者: Wang, Li ; Yu, Zhi-Ling ; Liu, Bin ; Mo, Huanbiao ; Fu, Xiu-Qiong ; Wu, Jia-Ying ; Wu, Ying ; He, Jin-Jin ; Han, Rui-Xuan ; Li, Amy Sze-Man ; Lu, Guang-Hua ; Yu, Xiao-Fei ; Wang, Xiao-Qi ; Tsui, Wilson Man-Shan

BACKGROUND:

Oncogenic mutations in the BRAF gene, particularly the V600E mutation, are present in roughly half of metastatic cutaneous melanoma cases. BRAF inhibitors (BRAFi) have shown significant clinical efficacy; however, their long-term effectiveness is frequently limited by the development of resistance. Parthenolide, a sesquiterpene lactone derived from medicinal herbs, has previously been reported to exhibit anti-melanoma effects and to disrupt signaling pathways associated with BRAFi resistance.

PURPOSE:

This study aimed to evaluate the potential of parthenolide to overcome resistance to BRAFi in melanoma.

STUDY DESIGN AND METHODS:

The effects of parthenolide on BRAFi-resistant melanoma cells were assessed using cell viability, apoptosis, and cell cycle assays. In vivo efficacy and safety were evaluated in a BRAFi-resistant melanoma xenograft mouse model. Target identification and validation were performed using network pharmacology, molecular docking, surface plasmon resonance, and Western blotting.

RESULTS:

Parthenolide inhibited cell viability and induced apoptosis and S-phase cell cycle arrest in BRAFi-resistant melanoma cells. In vivo, parthenolide significantly suppressed tumor growth and reduced tumor weight in BRAFi-resistant melanoma xenografts without apparent toxicity. Mechanistically, parthenolide stably interacted with the N-terminal ATPase domain of Hsp90α and dose-dependently inhibited its ATPase activity. Hsp90α functions as a chaperone for several oncoproteins involved in signaling pathways driving BRAFi resistance. Parthenolide reduced the levels of several Hsp90α client proteins and inhibited their downstream pathways, including PI3K/Akt, Ras/Raf/MEK, and Src/STAT3, in BRAFi-resistant melanoma cells. Moreover, the Hsp90 activator tamoxifen attenuated the effects of parthenolide in these cells.

CONCLUSION:

Our findings provide the first evidence that parthenolide can overcome BRAFi resistance in melanoma, highlighting its potential as a lead compound for the development of Hsp90α inhibitors to manage BRAFi-resistant cutaneous melanoma.

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