Akita University

Chem. durability tests were conducted on Japanese simulated high-level waste (HLW) glasses for 48 h, and the effect of addition of V2O5, ZrO2 and waste components on the leaching rate were examinedWe found that the normalized leaching mass loss of silicon and boron of waste-free glass became slow after 20 h, whereas linearly increased with increasing time in waste-bearing glass.This indicates importance of consideration of waste components in the chem. durability test of the HLW glass.Combined addition of V2O5 and ZrO2 with waste-bearing glasses has significantly reduced the chem. durability.It is estimated that the change of Si with Zr and V in a network-forming site reduced the Si-O-Si bonds and hindered the gel formation that protects glass.

HM-SCREEN-Japan is a multicenter collaborative project in Japan to evaluate the clinical utility of a cancer genome panel in the treatment of acute myeloid leukemia (AML). The HM-SCREEN-JAPAN02 study used the Amoy Myeloid Panel^® with the HANDLE system, which enables efficient and rapid sequencing, as the genomic testing kit. The Amoy Myeloid Panel^® targets 53 genes with established clinical significance or high prevalence. The study analyzed bone marrow fluid or peripheral blood. Multiple time points for submission were allowed to evaluate clonal changes over time. A total of 179 tests/145 patients with one or more pathogenic mutations (23 patients submitted specimens at multiple time points) were included in the analysis. A variety of patterns were detected, including acquisition of new resistance-associated genetic mutations and pathogenic mutations remaining after clinical remission. The median time required for sequencing and annotation was 8 days. TP53 and NRAS mutations were associated with increased risk of death (hazard ratio = 3.98 and 5.50, respectively). In a survey of physicians at the participating centers, 63% reported that the genomic panel was clinically useful, particularly for assessing clinical risk and evaluating indications for hematopoietic stem cell transplantation.

The Mesoarchaean Murchison Greenstone Belt is composed of a strongly deformed volcano-sedimentary succession metamorphosed up to amphibolite facies and surrounded by metaluminous and peraluminous granitoids in the north of the Kaapvaal Craton of southern Africa.A circa 40 km-long shear-zone of strongly carbonatised rocks (the Antimony Line, or Sb-Line) oriented along the main trend of the greenstone belt (WSW-ENE) hosts important Sb deposits with accessory Au.These commodities mostly occur as stibnite and native gold hosted by quartz-carbonate rocks at the center of the Sb-Line, underlining the importance of CO₂-rich fluid flow for mineralization during deformation and metamorphism.In this study, we compare the elemental and stable isotope (C-O-Mg) composition of carbonates from the Sb-Line with regionally distributed carbonates hosted by the volcano-sedimentary succession distal to mineralization.The carbonates of the Sb-Line and regional rocks have overlapping major element compositionsBoth magnesite and dolomite in most Sb-Line samples have marked light-REE-depleted patterns with variable pos. Eu anomalies.Carbon isotope ratios define two clusters, with marked δ¹³C peaks at ca. -5 ‰ for Sb-Line rocks and ca. -2 ‰ for regional rocks, implying sep. C-sources.The peak at ca. -2 ‰ likely represents early carbonatisation through sea-floor alteration, whereas the first peak at ca. -5 ‰ is indicative of deep CO₂ (mantle, or magma-derived) introduced during tectonic activity of the Sb-Line.Magnesium isotope ratios of regional rocks reveal limited fractionation (bulk δ²⁶Mg = -0.27 ± 0.10 ‰) that overlap with mantle values, but some carbonate-bearing veins present ²⁶Mg-depleted compositions (bulk δ²⁶Mg = -1.91 to -0.40 ‰).Sb-Line carbonated rocks have more fractionated Mg isotope compositions (bulk δ²⁶Mg = -0.8 to 0.0 ‰) and carbonates display marked neg. ²⁶Mg values (δ²⁶Mg from -1.46 to -0.31 ‰).We interpret these results in terms of preferential remobilisation of isotopically light Mg during fluid-rock interaction and dissolution of carbonate in the host-rocks.The lack of correlation between δ¹³C and δ²⁶Mg indicates decoupling of these isotopic systems, implying contribution from isotopically distinct sources of C and Mg to the mineralized zone.Similar to other structurally controlled Au-Sb mineralization in Archaean greenstone belts, metal transport and ore deposition in the Murchison Greenstone Belt was closely related to the deep cycle of carbon, linking C-draw-down during sea-floor alteration, carbonate re-mobilisation during metamorphism and CO₂ degassing from deep sources along major crustal discontinuities.In contrast to models for orogenic Au-Sb deposits invoking a purely intra-crustal, metamorphic origin of mineralizing fluids, our results underline the importance of deep-sourced fluids originating from an external source from the volcano-sedimentary succession.