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8

项与 University of Human Environments 相关的临床试验

Randomized controlled trial of a wellbeing smartphone application (Intellect app) aimed to reduce depressive symptoms in Japanese Working Adults presenting with depressive symptoms. - Randomized controlled trial of a wellbeing smartphone application (Intellect app) aimed to reduce depressive symptoms in Japanese Working Adults presenting with depressive symptoms.

开始日期2023-06-16

申办/合作机构

University of Human Environments

JPRN-UMIN000051082 / Recruiting

Effects of Nurses to Continuously Practice by a Nursing Practice Model for Glycerin Enema and Digital Extraction of Feces for Elderly People who Require At-home Nursing Care - Effects of Nurses to Continuously Practice for Defecationing Support by a Nursing Practice Model for Elderly People who Require At-home Nursing Care

开始日期2023-06-06

申办/合作机构

University of Human Environments

JPRN-UMIN000043270 / CompletedN/A

A randomized controlled trial of smartphone application for reducing gambling symptoms (Gamble Control) for Japanese high-risk gamblers - A randomized controlled trial of smartphone application for reducing gambling symptoms (Gamble Control) for Japanese high-risk gamblers

开始日期2023-01-06

申办/合作机构

University of Human Environments

100 项与 University of Human Environments 相关的临床结果

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0 项与 University of Human Environments 相关的专利（医药）

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206

项与 University of Human Environments 相关的文献（医药）

2024-07-31·Japanese Journal of Health and Human Ecology

An exploratory study on falls and behavioral factors among older adults living in the community

作者: TAKAGI, Ryosuke ; FUJII, Wakaya ; YAMAGUCHI, Natsuyo ; KATADA, Akiyoshi ; IKEDO, Saki ; HAYASHI, Setsuya

2024-07-31·Mammal Study

Habitat Use by Indo-Pacific Bottlenose Dolphins Settled in a New Area around Amakusa-Shimoshima Island, Japan

作者: Nishita, Miki ; Nishiyama, Masato ; Shirakihara, Miki ; Amano, Masao ; Kasedou, Teruo ; Shirakihara, Kunio ; Onoue, Toshiyuki

2024-05-10·Imaging Neuroscience

Neural mechanisms of the relationship between aerobic fitness and working memory in older adults: An fNIRS study

作者: Arao, Takashi ; Dan, Ippeita ; Naganawa, Sho ; Soya, Hideaki ; Jindo, Takashi ; Mukoyama, Ayako ; Hyodo, Kazuki ; Niioka, Kiyomitsu

AbstractA growing number of studies have revealed that higher aerobic fitness is associated with better working memory (WM) performance in older adults. However, the underlying functional neural mechanisms of this association remain under debate. It has been reported that aging increases recruitment of the prefrontal cortex (PFC) during cognitive tasks, and that this is associated with task performance in a compensatory manner. Therefore, this study aimed to clarify the prefrontal activation pattern that is associated with the relationship between aerobic fitness and WM performance in older adults, focusing on age-related extended prefrontal recruitment. Forty-seven older adults (65–74 years, 29 females) and 49 younger adults (18–24 years, 23 female) performed verbal and spatial n-back tasks, which included 0-, 1-, and 2-back conditions. Reaction time (RT) and accuracy (ACC) were assessed as indices of task performance. Prefrontal activation during the experimental tasks was monitored using functional near-infrared spectroscopy (fNIRS) and analyzed using an adaptive GLM method. We compared task performance and prefrontal activation between age groups to find age-related prefrontal activation patterns. Only older adults underwent a graded exercise test (GXT) to determine their ventilation thresholds (VT) as a measure of aerobic fitness, and, subsequently, the relationships among aerobic fitness, n-back task performance, and prefrontal activation in older adults were examined using correlation analysis and mediation analysis controlling for possible covariates. A comparison of task performance between groups revealed that older adults had slower RT and lower ACC than did younger adults, especially in the higher WM load 2-back condition. Group comparisons of prefrontal activation showed that older adults exhibited additional or greater activation than younger adults mainly in the ventrolateral PFC (VLPFC) and front polar area (FPA) in both the verbal and spatial 2-back conditions. Correlation analysis showed a relationship between higher VT, shorter RT for the verbal 2-back condition, and greater prefrontal activation of the bilateral FPA and right VLPFC during verbal 2-back conditions in older adults. In addition, mediation analyses indicated the possibility of a mediation effect of the prefrontal activation on the relationship between VT and RT for the verbal 2-back condition. These results suggest that older adults with higher aerobic fitness levels recruited more extended PFC regions, possibly for compensatory activation, to enhance their performance of the verbal n-back task. This study sheds light on the neural mechanisms underpinning the relationship between aerobic fitness and cognitive function in older adults.

100 项与 University of Human Environments 相关的药物交易

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100 项与 University of Human Environments 相关的转化医学

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