更新于：2024-11-01

Australian and New Zealand Intensive Care Research Centre

Australia

更新于：2024-11-01

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项与 Australian and New Zealand Intensive Care Research Centre 相关的临床试验

NCT05453565 / Not yet recruitingN/AIIT

Fluid Restricted Resuscitation in Sepsis With Hypotension Meta-Analysis (FRESHLY): Individual Patient Data Met-analysis of the ARISE FLUIDS, CLASSIC, CLOVERS and EVIS Trials

A prospective, individual patient data meta-analysis (IPDMA) of four multicentre, open-label, randomised clinical trials of initial haemodynamic resuscitation in patients with septic shock.

开始日期2024-11-01

申办/合作机构

Australian and New Zealand Intensive Care Research Centre

NCT06526533 / Not yet recruiting早期临床1期IIT

Reducing Major Complications to Improve the Safety and Efficacy of ECMO in Severe Cardiac and Respiratory Failure (RECOMMEND)

Patients in the intensive care unit (ICU) undergoing extracorporeal membrane oxygenation (ECMO) require close monitoring and interventions to support their recovery. The RECOMMEND Platform Trial aims to develop clear, high-quality evidence for ECMO care, to better inform clinicians in this rapidly evolving field.
The RECOMMEND Platform Trial will provide a 'platform' for funding, logistics, and training protocols. This approach enhances efficiency, allowing research to begin, and complete more efficiently. The platform maintains rigorous standards and provides a safe, cost-effective, and time-efficient method for generating knowledge about ECMO care.
Overall, platform clinical trials offer a dynamic and innovative approach that enables the simultaneous evaluation of multiple treatments and the rapid translation of scientific discoveries into improved patient care. The RECOMMEND Platform Trial has been informed by patient preferences and values and will evaluate the effectiveness and safety of various standards of care. This approach supports continuous learning and real-time clinical decision-making to improve patient outcomes.

开始日期2024-09-01

申办/合作机构

Australian and New Zealand Intensive Care Research Centre

[+2]

NCT06576895 / RecruitingN/AIIT

Nutrition Practice in Critically Ill Adults - an Observational Study

To determine the role of nutrition in recovery from critical illness, current practice must first be understood. However, no benchmarking process currently exists for nutrition practice during critical illness, from ICU admission to hospital discharge. This vital gap requires addressing.
The aim of this study is to inform and re-design models of nutrition care and generate research priorities for the future by obtaining data on nutrition provision and practice and that of consumer preference for nutrition care.

开始日期2024-08-26

申办/合作机构

Australian and New Zealand Intensive Care Research Centre

100 项与 Australian and New Zealand Intensive Care Research Centre 相关的临床结果

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0 项与 Australian and New Zealand Intensive Care Research Centre 相关的专利（医药）

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111

项与 Australian and New Zealand Intensive Care Research Centre 相关的文献（医药）

2024-10-01·Journal of Parenteral and Enteral Nutrition

Characteristics of enteral and oral nutrition support among infants and young children in the pediatric intensive care unit: A descriptive cohort study

Article

作者: McCall, Andrea ; Bollard, Tessa ; Menzies, Jessica ; Woodgate, Jemma ; Jenkins, Samantha ; Little, Bridget ; Sim, Kirsten ; Farrell, Tamara ; Rowe, Carla ; Winderlich, Jacinta ; Paul, Eldho ; Landorf, Emma ; Ridley, Emma J. ; O'Brien, Katie ; Oberender, Felix ; van der Wilk, Melanie ; Udy, Andrew A.

AbstractBackgroundChildren who are critically ill are often reliant on enteral and oral nutrition support. However, there is limited evidence to guide “what” to prescribe, and current practice is unknown. The primary objective of this study was to describe enteral nutrition prescription in children ≤2 years of age in the pediatric intensive care unit (PICU). The secondary objectives were to describe oral nutrition support practices and factors associated with the use of increased energy and protein density nutrition support.MethodsChildren ≤2 years of age admitted to participating PICUs over a 2‐week period in June 2021 were enrolled. Data were collected on PICU admission days 1 to 7, 14, 21, and 28 on the mode of nutrition, enteral and oral nutrition support prescription, and dietitian intervention.ResultsEighty‐four children were included (49 [58%] male; 79 [94%] ≤1 year of age). Enteral nutrition was administered to 79 (94%) children (with expressed breast milk in 45 [57%]). Forty‐three children received formula as enteral nutrition. Increased energy and protein density formulas were provided to 14 (33%) children enterally, with concentrated standard infant formula powder being the most common (5 [12%]). Among children offered oral intake (22; 26%), three (14%) received oral nutrition support. Children who received increased energy and protein density enteral nutrition were more likely to receive dietitian intervention (P = 0.002).ConclusionIn children ≤2 years of age admitted to PICU, expressed breast milk was provided to half of those requiring enteral nutrition and oral nutrition support prescription was infrequent. One third of children receiving formula via enteral nutrition received an increased energy and protein density feed, and this was strongly associated with dietitian intervention.

2024-09-15·American Journal of Respiratory and Critical Care Medicine

Impact of High-Dose Early Mobilization on Outcomes for Patients with Diabetes: A Secondary Analysis of the TEAM Trial

Article

作者: Bailey, Michael ; Brickell, Kathy ; Sivasuthan, Janani ; Tipping, Claire J. ; Gould, Doug W. ; Higgins, Alisa M. ; Zoungas, Sophia ; Harrold, Meg ; Young, Paul J. ; Broadley, Tessa ; Buhr, Heidi ; Presneill, Jeffrey J. ; Poole, Alex ; Nichol, Alistair D. ; Webb, Steven ; Iwashyna, Theodore J. ; Bellomo, Rinaldo ; Hurford, Sally ; Schaller, Stefan J. ; Serpa Neto, Ary ; Agli, Alicia ; Bradley, Scott ; Parke, Rachael ; Hodgson, Carol L. ; Gabbe, Belinda J. ; Seller, Daniel

Rationale: Patients with diabetes represent almost 20% of all ICU admissions and might respond differently to high-dose early active mobilization. Objectives: To assess whether diabetes modified the relationship between the dose of early mobilization on clinical outcomes in the TEAM trial. Methods: All TEAM trial patients were included. The primary outcome was days alive and out of the hospital at Day 180. Secondary outcomes included 180-day mortality and long-term functional outcomes at Day 180. Logistic and median regression models were used to explore the effect of high-dose early mobilization on outcomes by diabetes status. Measurements and Main Results: All 741 patients from the original trial were included. Of these, 159 patients (21.4%) had diabetes. Patients with diabetes had fewer days alive and out of the hospital at Day 180 (124 [0-153] vs. 147 [82-164]; P = 0.013) and higher 180-day mortality (30% vs. 18%; P = 0.044). In patients receiving high-dose early mobilization, the number of days alive and out of the hospital at Day 180 was 73.0 (0.0-144.5) in patients with diabetes and 146.5 (95.8-163.0) in patients without diabetes (P value for interaction = 0.108). However, in patients with diabetes, high-dose early mobilization increased the odds of mortality at 180 days (adjusted odds ratio, 3.47; 95% confidence interval, 1.67-7.61; P value for interaction = 0.001). Conclusions: In this secondary analysis of the TEAM trial, in patients with diabetes, a high-dose early mobilization strategy did not significantly decrease the number of days alive and out of the hospital at Day 180, but it increased 180-day mortality.

2024-07-01·Clinical Transplantation

What Happens to Frailty in the First Year After Lung Transplantation?

Article

作者: Fuller, Louise Mary ; Cristiano, Yvie ; Paul, Eldho ; Robinson, Rebecca ; Snell, Greg ; Whitford, Helen M. ; Steward, Ranjana ; Poulsen, Megan

ABSTRACTBackgroundFrailty is prevalent in lung transplant (LTx) candidates, but the impact and subsequent frailty trajectory is unclear. This study aimed to investigate frailty over the first year after LTx.MethodPost‐LTx recipients completed a thrice weekly 12‐week directly supervised exercise rehabilitation program. Edmonton Frail Scale (EFS) was used to assess frailty. Primary outcome was 6‐Minute Walk Distance (6MWD) measured at pre‐LTx, prerehabilitation, postrehabilitation, and 1 year post‐LTx.Results106 of 139 recruited participants underwent LTx: mean age 58 years, 48% male, 52% with chronic obstructive pulmonary disease. Mean (± SD) frailty scores pre‐LTx and 1 year post‐LTx were 5.54 ± 2.4 and 3.28 ±1.5. Mean 6MWD improved significantly for all: prerehabilitation 326 m (SD 116), versus postrehabilitation 523 m (SD 101) (p < 0.001) versus 1 year 512 m (SD 120) (p < 0.001). There were significant differences between an EFS > 7 (frail) and EFS ≤ 7 (not frail) for 6MWD, grip strength (GS), anxiety, and depression. Postrehabilitation, there were no significant differences in 6MWD, GS, anxiety, or depression while comparing EFS > 7 versus ≤ 7. At 1 year, there was a significant difference in depression but not 6MWD, GS, or anxiety between those EFS ≤ 7 and > 7 (p = 0.017).ConclusionParticipants in a structured post‐LTx rehabilitation program improved in functional exercise capacity (6MWD), GS, depression, and anxiety. For frail participants exercise capacity, depression, anxiety, and GS were well managed in rehabilitation with no significant differences between those who were not frail. Pre‐LTx frailty may be reversible post‐LTx and should not be an absolute contraindication to LTx.

100 项与 Australian and New Zealand Intensive Care Research Centre 相关的药物交易

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100 项与 Australian and New Zealand Intensive Care Research Centre 相关的转化医学

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