Fraunhofer Institute for Chemical Technology

ZUG, Switzerland, Oct. 03, 2024 (GLOBE NEWSWIRE) -- Pharvaris (Nasdaq: PHVS), a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to prevent and treat hereditary angioedema (HAE) attacks, today announced the acceptance of six abstracts, two for oral presentation and four for poster presentation, at the 2024 Global Angioedema Forum – HAEi Global Leadership Workshop, taking place in Copenhagen, Denmark, from Oct. 4-5, 2024. Details are as follows: Title: Long-Term Safety and Efficacy of Oral Deucrictibant, a Bradykinin B2 Receptor Antagonist, for Prophylaxis in Hereditary Angioedema: Results of the CHAPTER-1 Open-Label Extension StudyPresenter: Marc A. Reidel, M.D., M.S.Format: Oral and PosterDate, time: Oral: Saturday, Oct. 5, Session 5, 9:59 CEST (3:59 a.m. EDT) | Poster: Friday, Oct. 4, 18:00-18:30 CEST (12:00-12:30 p.m. EDT), Poster Walk 1Title: Long-Term Efficacy and Safety of Oral Deucrictibant, a Bradykinin B2 Receptor Antagonist, in Treatment of Hereditary Angioedema Attacks: Results of the RAPIDe-2 Extension StudyPresenter: Anna Valerieva, M.D., Ph.D.Format: Oral and PosterDate, time: Oral: Saturday, Oct. 5, Session 5, 10:08 CEST (4:08 a.m. EDT) | Friday, Oct. 4, 18:30-19:00 CEST (12:30-1:00 p.m. EDT), Poster Walk 4Title: Efficacy and Safety of Oral Deucrictibant, a Bradykinin B2 Receptor Antagonist, in Prophylaxis of Hereditary Angioedema Attacks: Results of CHAPTER-1 Phase 2 TrialPresenter: Emel Aygören-Pursun, M.D.Format: Poster Date, time: Friday, Oct. 4, 18:00-18:30 CEST (12:00-12:30 p.m. EDT), Poster Walk 3Title: Prophylactic Treatment With Oral Deucrictibant Improves Health-Related Quality of Life of Patients with Hereditary AngioedemaPresenter: Andrea Zanichelli, M.D., Ph.D.Format: PosterDate, time: Friday, Oct. 4, 18:30-19:00 CEST (12:30-1:00 p.m. EDT), Poster Walk 2Title: Propensity Score-Matched Comparison of Outcomes for Deucrictibant vs. Standard of Care in People Living with Hereditary AngioedemaPresenter: Danny M. Cohn, M.D., Ph.D.Format: PosterDate, time: Friday, Oct. 4, 18:30-19:00 CEST (12:30-1:00 p.m. EDT), Poster Walk 2Title: Design of RAPIDe-3 Phase 3 Trial: Efficacy and Safety of the Oral Bradykinin B2 Receptor Antagonist Deucrictibant Immediate-Release Capsule in Treatment of Hereditary Angioedema AttacksPresenter: Phillip H. Li, MBBS, FRCPFormat: PosterDate, time: Friday, Oct. 4, 18:00-19:00 CEST (12:00-1:00 p.m. EDT), Poster Walk 1 The presentation slides and posters will be available on the Investors section of the Pharvaris website at: https://ir.pharvaris.com/news-events/events-presentations. In memory of Prof. Marcus Maurer, Professor of Dermatology and Allergy, Executive Director of the Institute of Allergology at the Charité – Universitätsmedizin Berlin, and Co-Director of Allergology and Immunology at the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Pharvaris will make a donation to the Marcus Maurer Fellowship Program through GA2LEN, the Global Allergy and Asthma Excellence Network. About PharvarisPharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to prevent and treat HAE attacks. By directly pursuing this clinically proven therapeutic target with novel small molecules, the Pharvaris team aspires to offer people with all types of bradykinin-mediated angioedema effective, well-tolerated, and easy-to-administer alternatives to treat attacks, both prophylactically and on-demand. With positive data in both Phase 2 prophylaxis and on-demand studies in HAE, Pharvaris is encouraged to further develop deucrictibant. Pharvaris is currently enrolling a pivotal Phase 3 study for the on-demand treatment of HAE attacks and plans to initiate a pivotal Phase 3 study of deucrictibant for the prevention of HAE attacks in the coming months. For more information, visit https://pharvaris.com/.

AVK Innovation Award first, second and third place winners. Photo credit, all images: JEC JEC Forum DACH, launched by JEC Group (Paris, France) in partnership with AVK (Industrievereinigung Verstärkte Kunststoffe e.V., Frankfurt, Germany), the German Federation of Reinforced Plastics, has announced the winner of this year’s JEC Startup Booster competition as well as AVK Innovation Award first, second and third place winners. Five Startup Booster finalists pitched their innovations in front of the event’s jury of composites experts. After deliberation of the jury in a closed room, the winner is Carbocon (Dresden, Germany), is an independent service provider in the field of the innovative carbon-reinforced concrete building material. The company operates in different areas of business, ranging from civil engineering services to introducing new products and processes to the market. In this way, Carbocon seeks to advocate progress and sustainability in the building industry. Carbocon, Startup Booster winner. The AVK Innovation Awards support new products, components and applications made from fiber-reinforced plastics (FRP) and promote new processes and methods for the manufacture of FRP products with a specific focus on sustainable solutions. Nine companies and projects were welcomed on stage during the event and awarded for breaking new grounds in the field of composites: Products and Applications category First place: “Insulating Coupling Shaft for Rail Vehicles” – Leichtbauzentrum Sachsen GmbH and partner KWD Kupplungswerk Dresden GmbH Second place: “Electric Car Battery Housing Components Based on Innovative Continuous Fiber-Reinforced Phenolic Resin Composites” – SGL Carbon Third place: “High-Performance Recycled Carbon Fiber Materials (HiPeR)” – Composites Technology Center GmbH (CTC GmbH) and partners Faserinstitut Bremen e. V, Sächsisches Textilforschungsinstitut e.V., C.A.R. FiberTec GmbH; Faserinstitut Bremen e.V., Sächsisches Textilforschungsinstitut e.V., C.A.R. FiberTec GmbH; CFRI Carbon Fiber Recycle Industry Co., Ltd.; IHI Logistics and Machinery Corp.; and ICC Kanazawa Institute of Technology Innovative Processes and Methods category First place: “Chopped Fiber Direct Processing (CFP)” – KraussMaffei Technologies GmbH and partner Wirthwein SE Second place: “CIRC — Complete Inhouse Recycling of Thermoplastic Compounds” – Fraunhofer Institute for Production Engineering and Automation (IPA) and partners Schindler Handhabetechnik GmbH; and Vision & Control GmbH Third place: “CarboScreen — Sensor-Based Monitoring of Carbon Fiber Production” – CarboScreen GmbH, and partner Institute of Textile Technology at RWTH Aachen University Research and Science category First place: “Development of a Stereocomplex PLA Blend on a Pilot Plant Scale” – Faserinstitut Bremen e. V. Second place: “Fiber-Reinforced Salt as a Robust Lost Core Material” – Technical University of Munich, Chair of Carbon Composites and partners Apppex GmbH; and Haas Metallguss GmbH Third place: “VliesSMC — Recycled Carbon Fibers with a Second Life in the SMC Process” – Sächsisches Textilforschungsinstitut e.V. (STFI) and partner Fraunhofer Institute for Chemical Technology (ICT).

Photo Credit: Sumitomo Bakelite Europe (Ghent) NV The rapid electrification of automotive powertrains and the emerging urban air mobility (UAM) market will create numerous opportunities for composites suppliers based in phenolics and epoxies. These were the key messages delivered at the Composites for Future Mobility Conference organized by thermoset plastics specialist Sumitomo Bakelite Europe (Ghent) NV (Ghent, Belgium), a subsidiary of Sumitomo Bakelite Co., Ltd. – Japan, at the end of March 2023. The conference attracted more than 50 experts from important OEMs, suppliers and research institutes working in the automotive and aerospace industries, including Ford Motor Co., Volkswagen (VW), Mahle, GKN Aerospace, Denso Automotive, Robert Bosch, Infineon Technologies, Vitesco Technologies and the Fraunhofer Institute for Chemical Technology (ICT). The managing director of Sumitomo Bakelite Europe (Ghent) NV, Pieter Vanderstraeten, told conference delegates, “Five years ago, we were asking ourselves whether plug-in hybrid powertrains or fully electric powertrains would become dominant in future. Today, we must ask ourselves if there is even a future for conventional powertrain technologies. The human coronavirus pandemic and the current geopolitical situation have also created a need for strong local supply chains, rather than global ones.” These trends were obvious in the presentations from OEMs at the conference and are believed will create significant opportunities for composites. OEMs need electric motors that are more energy-efficient and power-dense than current alternatives. VW’s team leader for process development and power electronics, Jan Winter, told conference attendees that the carmakers’ sales of electric vehicles (EVs) will surpass those of cars with internal combustion engines (ICEs) by 2030. VW is creating an entirely new platform, the Scalable Systems Platform, for all the EVs it produces across its numerous brands and is developing much of the technology for its future electric powertrains in-house. In particular, VW is using composites in the production of its current electric motors and Winter also sees opportunities for the strong, lightweight materials in the production of new types of motors, and for the encapsulation of power modules. Similarly, Ford’s technical expert for E-machines, Franco Leonardi, told delegates that EVs will account for more than 50% of the carmaker’s sales by 2030. The carmaker is also using composites in the development of its rotor and stator technologies for electric motors. The potential of composites to produce components for electrified powertrains was illustrated by two demonstrators developed by Sumitomo Bakelite and shown during the event. The first was a high-energy-density battery module with a strong, durable housing made from flame-resistant and thermal runaway-delaying phenolic molding compounds. The housing maintains its structural integrity in the event of a crash and is 40% lighter in weight than conventional alternatives. The second demonstrator was a lightweight, compact and cost-effective E-axle with a phenolic compound housing that demonstrates optimal noise, vibration and harshness (NVH) behavior, and a stator with epoxy compound insulation, encapsulation and integrated cooling that increases its power density. According to Sumitomo, technologies such as these being developed by the automotive industry could also find use in the UAM market. Motors for electric vertical takeoff and landing craft (eVTOL) must also be light in weight, efficient and reliable (see “Composites opportunities in eVTOLs”). Engineering manager for electric propulsion at Denso Automotive, Christoph Mueller, told the conference about the motors his company is developing for these aircraft. To reduce their weight, the company is exploring the use of composites for the production of motors and for the encapsulation of parts of the rotors and stators. Mueller said that there could be tens of thousands of eVTOLs in the air within the next decade. Sumitomo Bakelite Europe (Ghent) NV is also experiencing change. From April this year, it will shed its previous name, Vyncolit NV, and it is adding epoxy molding compounds to the portfolio of products that it manufactures, having invested in a state-of-the-art epoxy plant at its Ghent facility. As the presentations at the conference made clear, composites based on epoxies and phenolics will be key enabling technologies as the world transitions to a net-zero emissions economy.