Sunrock Biopharma SL

LAUSANNE, Switzerland & SANTIAGO DE COMPOSTELA, Spain--(BUSINESS WIRE)-- Debiopharm ( ), a privately-owned, Swiss-based, biopharmaceutical company aiming to establish tomorrow’s standard-of-care to cure cancer and infectious diseases, today secured an option to enter an exclusive licensing deal with SunRock Biopharma ( ), a Galician company supported by the regional government, Xunta de Galicia, through Xes Galicia. SunRock is devoted to the development of sophisticated, bispecific antibodies against highly invasive tumors with an urgent clinical need in oncology and will benefit from Debiopharm’s Multilink™ technology to produce an enhanced HER3-EGFR bispecific antibody-drug conjugate (ADC). This option agreement prolongs the existing partnership that was initiated in September of this year allowing Debiopharm to further develop HER2/HER3 targeting antibodies. “At Debiopharm, we are actively scouting for opportunities to apply our proprietary linker technology, Multilink™, in a way that complements the licensed antibodies. MultilinkTM has been engineered to produce ADC with high drug to antibody ratio and excellent stability in circulation, to avoid premature drug release, and to increase treatment specificity and effectiveness,” commented Frederic Levy, Chief Scientific Officer of Debiopharm. Over the past five years, ADCs have gained enormous momentum and become standard-of-care for the treatment of many cancers. The success of this therapeutic class is mainly linked to the possibility of chemically conjugating cytotoxic payloads onto antibodies, thereby combining the targeted specificity of antibodies with the lethality of cytotoxic payloads while minimizing damage to healthy tissue. "We are thrilled to enhance our partnership with Debiopharm. This collaboration enables us to merge our innovative expertise in bispecific antibodies with Debiopharm's cutting-edge Multilink™ technology. Together, we're paving new paths to address highly aggressive cancers with critical clinical needs. It's a significant step in our quest to deliver more effective, targeted therapies to patients,” commented Laureano Simón, CEO of SunRock Biopharma. About Multilink™ Multilink™ is a new cleavable linker platform suited for multidrug attachment and compatible with any conjugation technology to produce ADCs with high DAR (drug-to-antibody ratio). This unique and innovative technology allows the loading of multiple payloads on an antibody for an enhanced therapeutic effect. This highly efficient and well-tolerated linker platform is available for use by other specialty biotech or pharmaceutical companies to generate proprietary, clinical-stage ADCs. About SunRock Biopharma SunRock Biopharma is a biotech company devoted to the development of therapeutic antibodies against highly invasive tumors with an urgent clinical need. SunRock has developed a unique portfolio of first-in-class and best-in-class therapeutic antibodies and bispecific antibodies against novel targets, such as CCR9 and well-known targets such as HER3. About Debiopharm Debiopharm develops innovative therapies that target high unmet medical needs in oncology and infectious diseases. Bridging the gap between disruptive discovery products and international patient reach, we identify high-potential compounds and technologies for in-licensing, clinically demonstrate their safety and efficacy and then select large pharmaceutical commercialization partners to maximize patient access globally. Visit us Follow us on Twitter @DebiopharmNews at Follow us on LinkedIn at

The partnership will advance antibody drug conjugates for hard-to-treat cancers. Credit: Pawel Giovanni Cancemi/Shutterstock.com. Debiopharm and SunRock Biopharma have signed an exclusive option and licence agreement to advance the development of specifically targeted antibody drug conjugates (ADCs) for hard-to-treat cancers. Under the agreement, Debiopharm will further develop SunRock’s antibodies by incorporating its linker technologies, Multilink and AbYlink, for creating the new ADCs. Recommended Reports Reports LOA and PTSR Model - DF-9001 in Gastric Cancer GlobalData Reports LOA and PTSR Model - PEG-irinotecan in Gastric Cancer GlobalData View all Companies Intelligence Multilink, Inc. Debiopharm SA SunRock Biopharma SL View all New ADCs are being developed to target tumour-specific antigens for fighting cancers with significant unmet needs, including the types of tumours that express HER2/HER3. SunRock Biopharma CEO Laureano Simón said: “We are really enthusiastic about the powerful synergy of SunRock antibodies and bispecific antibodies with Debiopharm’s ADC platform and clinical development capabilities.” Multilink, a new cleavable linker platform intended for multidrug attachment, is compatible with any conjugation technology to create ADCs with a high drug-to-antibody ratio (DAR). This technology enables multiple payloads loading on an antibody for improved therapeutic effect. Pharmaceutical or other speciality biotech companies can use this platform for generating clinical-stage ADCs. AbYlink is a rapid antibody conjugation technology for diagnostic uses and ADC preparation. It is a site-selective method that provides defined and invariable conjugation sites without any impact on antigen-binding regions. Using this technology, researchers can design ADCs with improved safety, efficacy and specificity to meet the unmet medical requirements of patients through ADC innovation. Debiopharm CEO Bertrand Ducrey said: “Our partnership with SunRock could result in the creation of highly innovative antibody-drug conjugates with the potential to tackle cancer in a new way and ultimately improve the lives of cancer patients.”

Debiopharm to boost its ADC oncology pipeline through multi-asset partnership with SunRock’s antibody portfolio integrating Multilink™ & AbYlink™ technologies LAUSANNE, Switzerland & SANTIAGO DE COMPOSTELA, Spain--(BUSINESS WIRE)-- Debiopharm ( ), a privately-owned, Swiss-based, biopharmaceutical company aiming to establish tomorrow’s standard-of-care to cure cancer and infectious diseases, today announced an exclusive option and license agreement with SunRock Biopharma ( ), a Galician company supported by the regional government, Xunta de Galicia, through Xesgalicia, devoted to the development of antibodies against highly invasive tumors with an urgent clinical need in oncology, for the advancement of the development of specifically targeted antibodies. The agreement offers Debiopharm licensing options to further develop SunRock’s antibodies integrating Debiopharm’s innovative linker technologies, Multilink™ and AbYlink™, to create innovative antibody drug conjugates (ADCs). Novel ADCs will be developed with capacity to target tumor-specific antigens to fight cancers with high unmet need, including those tumor types expressing HER2/HER3. ADCs are emerging as promising therapies in the fight against cancer due to their unique ability to target and destroy cancer cells selectively while minimizing damage to healthy tissues. These innovative therapeutics combine the precise targeting capabilities of monoclonal antibodies with the potent cytotoxic effects of small molecule drugs, resulting in a powerful synergistic effect. By harnessing the specificity of antibodies, ADCs can recognize and bind to tumor-specific antigens on the surface of cancer cells, ensuring that the toxic payload is delivered directly to its intended target. This precise approach not only enhances therapeutic efficacy but also reduces systemic toxicity and side effects commonly associated with traditional cancer treatments. “Our partnership with SunRock could result in the creation of highly innovative antibody-drug conjugates with the potential to tackle cancer in a new way and ultimately improve the lives of cancer patients,” commented Bertrand Ducrey, CEO of Debiopharm. “In a time when few new modalities show promise in effectively beating cancer, the potential of this collaboration is sparking scientific curiosity by combining biology and chemistry.” Advancements in linker technology have improved ADC stability in circulation, reducing premature drug release and further increasing treatment specificity and effectiveness. Debiopharm’s unique Multilink™ technology can be used to create ADCs that are significantly more effective and better tolerated as it allows the loading of multiple payloads on an antibody. AbYlink™ is an antibody conjugation technology suited to rapidly generate new antibody drug conjugates or imaging antibodies while preserving the original affinity of the antibody to its target. “We’re highly motivated to uncover the potential of these antibodies with well-validated oncology targets such as HER2 and HER3,” expressed Frederic Levy, Senior Executive Director, Search & Evaluation and Scientific Innovation. “Combining these promising molecules with our linker technology could really boost efficacy and safety to outsmart a wide variety of cancers with a high unmet medical need.” “We are really enthusiastic about the powerful synergy of SunRock antibodies and bispecific antibodies with Debiopharm’s ADC platform and clinical development capabilities,” commented Laureano Simón, CEO of SunRock Biopharma. About Multilink™ Multilink™ is a new cleavable linker platform suited for multidrug attachment and compatible with any conjugation technology to produce ADCs with high DAR (drug-to-antibody ratio). This unique and innovative technology allows the loading of multiple payloads on an antibody for an enhanced therapeutic effect. This highly effective and well-tolerated linker platform is available for use by other specialty biotech or pharmaceutical companies to generate proprietary, clinical-stage ADCs. About AbYlink™ AbYlink™ is a versatile and rapid antibody conjugation technology for diagnostic purposes and ADC preparation. This site-selective method offers defined and invariable conjugation sites with no impact on antigen-binding regions. It facilitates a seamless, homogenous antibody conjugation process between antibodies and cytotoxic drugs, ensuring optimal stability and controlled drug release at the site of action. AbYlink empowers researchers to design ADCs with enhanced efficacy, safety, and specificity that can address unmet medical needs of patients through cutting-edge ADC innovation. About SunRock Biopharma SunRock Biopharma is a biotech company devoted to the development of therapeutic antibodies against highly invasive tumors with an urgent clinical need. SunRock has developed a unique portfolio of first-in-class and best-in-class therapeutic antibodies and bispecific antibodies against novel targets, such as CCR9 and well-known targets such as HER3. About Debiopharm Debiopharm develops innovative therapies that target high unmet medical needs in oncology and infectious diseases. Bridging the gap between disruptive discovery products and international patient reach, we identify high-potential compounds and technologies for in-licensing, clinically demonstrate their safety and efficacy and then select large pharmaceutical commercialization partners to maximize patient access globally. Visit us Follow us on Twitter @DebiopharmNews at Follow us on LinkedIn View source version on businesswire.com: Contacts Debiopharm Dawn Bonine – Head of Communications dawn.bonine@debiopharm.com Tel: +41 (0)21 321 01 11 Source: Debiopharm View this news release online at: