Delving into the Latest Updates on The Prince Charles Hospital with Synapse

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1

项与 The Prince Charles Hospital 相关的药物

Mesenchymal Stromal Cells(The Prince Charles Hospital)

靶点-

作用机制

干细胞替代物

在研机构-

原研机构

The Prince Charles Hospital

在研适应症-

非在研适应症

闭塞性细支气管炎

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

52

项与 The Prince Charles Hospital 相关的临床试验

ACTRN12623001198617 / Not yet recruitingN/AIIT

Evaluation of wavelet semblance analysis for determining the lower limit of cerebral autoregulation in a non-cardiac surgery population

开始日期2024-01-08

申办/合作机构

The Prince Charles Hospital

ACTRN12623000333617 / RecruitingN/AIIT

Comparing the acceptability and treatment fidelity of digital pre-operative education to face-to-face physiotherapy pre-operative education in patients awaiting elective thoracic surgery: A pilot feasibility randomised controlled trial.

开始日期2023-11-20

申办/合作机构

The Prince Charles Hospital

NCT06035055 / Not yet recruiting临床4期IIT

The Feasibility of Ceftolozane/Tazobactam Continuous Infusion for Exacerbations of Cystic Fibrosis and Bronchiectasis Treated in an Outpatient Parenteral Antibiotic Therapy (OPAT) Setting

The goal of this clinical trial is to assess the feasibility of ceftolozane/tazobactam (C/T) administered on an outpatient parenteral antibiotic therapy programme to patients with a current infective exacerbation of bronchiectasis or cystic fibrosis related to pseudomonas aeruginosa or burkholderia cepacia spp. organisms. The main question[s] it aims to answer are:
Is C/T effective, safe, well-tolerated and able to induce clinical and microbiologic response?
What are mechanisms of antimicrobial resistance are induced by administration of C/T?

开始日期2023-10-01

申办/合作机构

The Prince Charles Hospital

100 项与 The Prince Charles Hospital 相关的临床结果

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0 项与 The Prince Charles Hospital 相关的专利（医药）

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2,592

项与 The Prince Charles Hospital 相关的文献（医药）

2024-12-01·Journal of Critical Care

Authors response: “Association between elevated lactate and clinical outcomes in adults with diabetic ketoacidosis”

Letter

作者: Shaikh, Arif ; Tabah, Alexis ; Zahumensky, Amanda ; Kumar, Aashish ; Laupland, Kevin B ; Ramanan, Mahesh ; Doola, Ra'eesa

2024-11-01·Thorax

Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease

Article

作者: Chai, Gin Tsen ; Moodley, Yuben P ; Galbraith, Michelle ; Wilsher, Margaret L ; Corte, Tamera ; Jo, Helen ; Royals, Karen ; de Boer, Sally ; Ng, Ziqin ; Tan, Geak Poh ; Troy, Lauren ; Edwards, Adrienne ; Reynolds, Paul N ; Thien, Francis ; Veitch, Elizabeth ; Li, Andrew ; Wrobel, Jeremy ; Khor, Yet Hong ; Keir, Gregory J ; Ong, Chong ; Glaspole, Ian ; Kwan, Benjamin ; Jackson, Dan ; Grainge, Christopher ; Chambers, Daniel C ; Teoh, Alan ; Goh, Nicole ; Gallagher, Henry ; Mackintosh, John

BackgroundLung function testing remains a cornerstone in the assessment and management of interstitial lung disease (ILD) patients. The clinical implications of the Global Lung function Initiative (GLI) reference equations and the updated interpretation strategies remain uncertain.MethodsAdult patients with ILD with baseline forced vital capacity (FVC) were included from the Australasian ILD registry and the National Healthcare Group ILD registry, Singapore.The European Coal and Steel Community and Miller reference equations were compared with the GLI reference equations to assess (a) differences in lung function percent predicted values; (b) ILD risk prediction models and (c) eligibility for ILD clinical trial enrolment.ResultsAmong 2219 patients with ILD, 1712 (77.2%) were white individuals. Idiopathic pulmonary fibrosis (IPF), connective tissue disease-associated ILD and unclassifiable ILD predominated.Median FVC was 2.60 (2.01–3.36) L, forced expiratory volume in 1 s was 2.09 (1.67–2.66) L and diffusing capacity of the lungs for carbon monoxide (DLCO) was 13.60 (10.16–17.60) mL/min/mm Hg. When applying the GLI reference equations, the mean FVC percentage predicted was 8.8% lower (87.7% vs 78.9%, p<0.01) while the mean DLCO percentage predicted was 4.9% higher (58.5% vs 63.4%, p<0.01). There was a decrease in 19 IPF and 119 non-IPF patients who qualified for the nintedanib clinical trials when the GLI reference equations were applied. Risk prediction models performed similarly in predicting mortality using both reference equations.ConclusionApplying the GLI reference equations in patients with ILD leads to higher DLCO percentage predicted values and smaller lung volume percentage predicted values. While applying the GLI reference equations did not impact on prognostication, fewer patients met the clinical trial criteria for antifibrotic agents.

2024-11-01·British Journal of Oral and Maxillofacial Surgery

Who let the dogs out? A 10-year review of maxillofacial dog bite injuries

Article

作者: Hulbert, J ; Lewis, K ; Meek, E. ; Mustafa, S ; Meek, E ; Hulbert, J. ; Lewis, K. ; Mustafa, S.

Dog bites are common within the United Kingdom, with their incidence increasing over recent years. Bites to the head and neck region can have substantial and multifactorial implications for victims, and can provide a challenge to maxillofacial departments. This study is a 10-year retrospective review of head and neck dog bites that required input from the maxillofacial team within the Cwm Taf Morgannwg University Health Board. Data collected included demographics of the patients involved, relationship with and breed of dog, nature of the injury, treatment received, and nature of any complications. In total, 168 records matched our inclusion criteria. The median age of our cohort was 12 years, with 57.1% of patients being younger than 15. Of the patients, 52.4% were female. Eighty-three per cent of cases involved a known dog, with Jack Russells being the breed most commonly involved. The upper lip was the most commonly affected area (30.3%), followed by the cheek (24.5%). Twenty-eight per cent of patients were admitted for management in theatre, with 8% of the total patients experiencing a complication. In conclusion, head and neck dog bites most commonly affect children and the upper lip.

100 项与 The Prince Charles Hospital 相关的药物交易

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100 项与 The Prince Charles Hospital 相关的转化医学

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