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The DoD states that infectious diarrhoea is the most common illness that US troops deployed overseas experience. Image credit: Shutterstock / Andrew Angelov. Immuron Limited has won an A$3.5m ($2.3m) grant to develop a version of its anti-diarrhoeal medication Travelan, following support from the US Department of Defense (DoD). The financing will fund a new agreement with the Naval Medical Research Command and Walter Reed Army Institute of Research, the latter being the largest biomedical research facility overseen by the DoD. The aim of the collaboration is to develop an enhanced formulation of Travelan for military use against pathogens that cause diarrhoea, according to a 16 August press release. The new version will target bacterial pathogens Campylobacter, Shigella and Enterotoxigenic E coli strains (ETEC) that are not present in the current product formulation. Travelan is an over-the-counter bovine colostrum product. Bovine colostrum is cow’s milk secreted during the first few days after calving and contains a range of immunoglobulins, growth factors, and cytokines that help with immune protection. Travelan is a highly purified tablet preparation that prevents bacteria colonisation in the digestive tract associated with travellers’ diarrhoea. See Also: Licensing agreements for innovator GLP1R drugs weigh in with over $6.2bn in 2024 Top 20 biopharmas’ market cap up 4.3% in Q2 2024 as GLP-1 drug innovators hold top spots The US DoD has already been working with Australia-based Immuron as it eyes wider effectiveness against diarrhoeal pathogens. The Naval Medical Research Command has ongoing ETEC and Campylobacter research programmes with the company while the Walter Reed Army Institute of Research is investigating the medication’s protection against Shigella. In the past, the DoD has provided $3.43m to perform a randomised double-blind placebo-controlled Phase II trial (NCT05933525) for ETEC infection testing a once-daily dosing schedule for the treatment. Immuron reported positive interim topline results from the study in March 2024, which showed that ETEC-induced moderate to severe diarrhoea was reduced by 36.4% following Travelan treatment compared to placebo.  The protective efficacy of once-daily dosing was around 50% as effective as the currently recommended three times daily dosing regimen; Immuron stated this was a strong result given the lower-than-expected attack rate in the study. Based on the results, the company is proceeding to Phase III registration strategy with the US Food and Drug Administration (FDA). Immuron said the new award aims to “identify and define pathways to formulate, characterise and perform preclinical testing of a military-relevant combined colostrum product”. Infectious diarrhoea is the most common illness that US troops deployed overseas experience, according to a 2019 DoD Infectious Disease Threats Prioritisation Panel. The government agency has also been funding a vaccine to immunise against ETEC. Scandinavian Biopharma is developing the lead candidate called ETVAX – an oral whole-cell vaccine – that demonstrated a positive safety and immunogenic profile in Phase IIb trial results published last year in The Lancet .

COPENHAGEN, Denmark, Jan. 26, 2023 /PRNewswire/ -- The Scandinavian Biotech company, Tetra Pharm Technologies has secured €9M in a series A round led by a group of Danish investors. The company, with operations in Copenhagen, Denmark focuses on therapeutics targeting the endocannabinoid system to treat neuropathic pain and mental health disorders. With the investment, Tetra Pharm Technologies will increase its capacity in Research and Development and expand its commercial operations internationally. Continue Reading Tetra Pharm Technologies - Laboratory "We have a promising pipeline of drugs that we believe carries the ability to treat - and potentially cure - health conditions stemming from certain imbalances in the endocannabinoid system. The additional funding enables us to accelerate formulation development and clinical activities", says Dr. Morten Allesø, CSO, Tetra Pharm Technologies. During 2022, Tetra Pharm Technologies closed several significant distribution deals across their main markets in Europe, and the company expect to release its first product to treat neuropathic pain in February 2023. "We are delighted to welcome our new investors and look forward to our partnership with them. The investment will create a strong platform to accelerate our current product portfolio and it provides us with an opportunity to finalize the promising drugs we have under development so we can continue to deliver on our mission to improve the lives of patients and their families, by formulating efficient drugs, with a low side-effect profile, at a fair price" added Martin Rose, CEO, Tetra Pharm Technologies. About Tetra Pharm Technologies Tetra Pharm Technologies is a Danish Biopharmaceutical company with a mission to improve treatment of neuropathic pain and mental health disorders globally. Its shareholders include leading commercialisation investors, including Leafy Tunnel, Enexis, Rump Invest, Nesroht Holding and Ole GS Holding. For more information, please visit For further information, please contact: Martin Caspersen: [email protected]; +45 61224241; Photo - Logo - SOURCE Tetra Pharm Technologies