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项与 Wesley Medical Research 相关的临床试验

ACTRN12622000487718 / Not yet recruitingN/A

Metabolomics in Ehancing Responses to ImmunoTherapy - in adult Melanoma patients

开始日期2022-06-01

申办/合作机构

Wesley Medical Research

ACTRN12621001327875 / Not yet recruiting临床4期

A prospective, randomised non-blinded pilot study to investigate the effect of oral tranexamic acid on the recovery time in patients undergoing primary total knee arthroplasty.

开始日期2021-10-01

申办/合作机构

Wesley Medical Research

ACTRN12621000781842 / RecruitingN/A

A Double-Blind, Placebo-Controlled, Adaptive Dose-Response Study To Assess the Acute Effects of Gluten in Adults with Treated Coeliac Disease (Gluten Threshold Study”)

开始日期2021-07-29

申办/合作机构

Wesley Medical Research

100 项与 Wesley Medical Research 相关的临床结果

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0 项与 Wesley Medical Research 相关的专利（医药）

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49

项与 Wesley Medical Research 相关的文献（医药）

2024-10-01·Journal of Paediatrics and Child Health

Letter to the Editor

Letter

作者: Franklin, Donna ; Schibler, Andreas

2024-07-01·Perfusion

Iliopsoas haematoma during extracorporeal membrane oxygenation: A registry report from the COVID-19 critical care consortium across 30 countries

Article

作者: Jacobs, Jeffrey P ; Suen, Jacky Y ; Cespedes, Marcela ; Rätsep, Indrek ; Li Bassi, Gianluigi ; Heinsar, Silver ; Fraser, John F ; Liu, Keibun ; Peek, Giles J ; Taniguchi, Hayato

Introduction Iliopsoas haematoma (IPH) during extracorporeal membrane oxygenation (ECMO) is a rare bleeding complication that can be fatal due to its progression to abdominal compartment syndrome, but its incidence and risk factors are not well known. We have previously reported an IPH incidence rate of 16% in Japan. Among possible reasons for this high incidence, ethnicity has been hypothesised to play a role. Therefore, we used an international multi-centre cohort registry to test this hypothesis by determining the incidence rate of IPH. Methods This study was performed using the COVID-19 Critical Care Consortium database, conducted in 30 countries across five continents between 3 January 2020, and 20 June 2022. Results Overall, 1102 patients received ECMO for COVID-19-related acute respiratory distress syndrome. Of them, only seven were reported to have IPH, indicating an incidence rate of 0.64%, with comparable rates between the countries. The IPH group tended to have a higher mortality rate (71.4%) than the non-IPH group (51%). Conclusions Overall incidence of IPH in the studied COVID-19 ECMO cohort was 0.64%. Most cases were reported from Japan, Belgium, and Italy. In our study, this rare complication did not appear to be confined to Asian patients. Due to the high fatality rate, awareness about the occurrence of IPH should be recognised.

2024-06-01·Journal of Neuropsychology

Verbal and nonverbal fluency in amyotrophic lateral sclerosis

Article

作者: Robinson, Gail A ; Ceslis, Amelia ; Argall, Rosemary ; Henderson, Robert D ; McCombe, Pamela ; Barker, Megan S

AbstractAmyotrophic lateral sclerosis (ALS) is a multi‐system disorder that commonly affects cognition and behaviour. Verbal fluency impairments are consistently reported in ALS patients, and we aimed to investigate whether this deficit extends beyond the verbal domain. We further aimed to determine whether deficits are underpinned by a primary intrinsic response generation impairment (i.e., a global reduction across tasks), potentially related to apathy, or an inability to maintain responding over time (i.e., a ‘drop off’ pattern). Twenty‐two ALS patients and 21 demographically‐matched controls completed verbal and nonverbal fluency tasks (phonemic/semantic word fluency, design fluency, gesture fluency and ideational fluency), requiring the generation of responses over a specified time period. Fluency performance was analysed in terms of the overall number of novel items produced, as well as the number of items produced in the first ‘initiation’ and the remaining ‘maintenance’ time periods. ALS patients' overall performance was not globally reduced across tasks. Patients were impaired only on meaningful gesture fluency, which requires the generation of gestures that communicate meaning (e.g., waving). On phonemic fluency, ALS patients showed a ‘drop off’ pattern of performance, where they had difficulty maintaining responding over time, but this pattern was not evident on the other fluency tasks. Apathy did not appear to be related to fluency performance. The selective meaningful gesture fluency deficit, in the context of preserved meaningless gesture fluency, highlights that the retrieval of action knowledge may be weakened in early ALS.

100 项与 Wesley Medical Research 相关的药物交易

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100 项与 Wesley Medical Research 相关的转化医学

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