Efficacy of 10 percent Nanohydroxyapatite Paste as Desensitizer alone and in Combination with 940nm Diode Laser in Treatment of Dentin Hypersensitivity – A Split-Mouth Single Blind Clinical Trial. - NIL

开始日期2024-09-25

申办/合作机构

SRM University

CTRI/2024/07/070517 / Not yet recruiting临床3期IIT

Comparative Evaluation of Perioperative Analgesic and Anaesthetic Efficacy in Supraperiosteal Infiltration of Tramadol Hydrochloride in patients with Symptomatic Irreversible Pulpitis – A Triple-blind randomized controlled trial.

开始日期2024-07-26

申办/合作机构

SRM University

CTRI/2024/06/068805 / Not yet recruitingN/AIIT

Comparative evaluation of crestal bone loss between SLA and RBM surface implants in Narrow Alveolar ridges with Osseo densification technique - An Observational clinical trial. - NIL

开始日期2024-07-15

申办/合作机构

SRM University

100 项与 SRM University 相关的临床结果

登录后查看更多信息

0 项与 SRM University 相关的专利（医药）

登录后查看更多信息

20,471

项与 SRM University 相关的文献（医药）

2025-03-01·Recent Patents on Biotechnology

Role of Artificial Intelligence in Drug Discovery to Revolutionize the Pharmaceutical Industry: Resources, Methods and Applications

作者: Singh, Pranjal Kumar ; Sachan, Kapil ; Khandelwal, Vishal ; Singh, Sumita ; Singh, Smita

Abstract:Traditional drug discovery methods such as wet-lab testing, validations, and synthetic techniques are time-consuming and expensive. Artificial Intelligence (AI) approaches have progressed to the point where they can have a significant impact on the drug discovery process. Using massive volumes of open data, artificial intelligence methods are revolutionizing the pharmaceutical industry. In the last few decades, many AI-based models have been developed and implemented in many areas of the drug development process. These models have been used as a supplement to conventional research to uncover superior pharmaceuticals expeditiously. AI's involvement in the pharmaceutical industry was used mostly for reverse engineering of existing patents and the invention of new synthesis pathways. Drug research and development to repurposing and productivity benefits in the pharmaceutical business through clinical trials. AI is studied in this article for its numerous potential uses. We have discussed how AI can be put to use in the pharmaceutical sector, specifically for predicting a drug's toxicity, bioactivity, and physicochemical characteristics, among other things. In this review article, we have discussed its application to a variety of problems, including de novo drug discovery, target structure prediction, interaction prediction, and binding affinity prediction. AI for predicting drug interactions and nanomedicines were also considered.

2025-02-01·Combinatorial Chemistry & High Throughput Screening

Mixed Solvency Concept to Replace Harmful Organic Solvent: Recent Trends and Future Challenges in Formulation Development

Article

作者: Singh, Pranjal Kumar ; Bhardwaj, Poonam ; Singh, Smita ; Sachan, Kapil ; Singh, Nidhi ; Singh, Atul Pratap

Abstract:Organic solvents are hazardous and should be replaced with less harmful alternatives. When developing a new formulation for a medicine with low aqueous solubility, improving its solubility might be a significant difficulty. According to the mixed solvency concept, a novel concept of solubilization, the solubility of poorly soluble drugs can be increased by dissolving them in a concentrated solution comprising various substances. Methods commonly used to improve solubility include complexation, pH modification, salt formation, hydrotropy, cosolvency, and micelle solubilization. By reducing the concentration of specific solubilizers, this method can be used to reduce the toxicity of solubilizers in various formulations of poorly soluble medicines. This review aims to provide scientists with a fresh concept for enhancing medication solubility. The benefits and drawbacks of currently available green solvents have been analyzed as potential replacements for traditional solvents. Some examples of these solvents are bio-based solvents like ethanol, methanol, and cyrene; d-limonene; deep eutectic solvents such as ionic liquids and natural deep eutectic solvents; supercritical fluids; subcritical water; surfactant-based solutions like hydrotopes and supramolecular solvents; and deep eutectic solvents like cyrene.

2025-01-01·Journal of Colloid and Interface Science

Deep eutectic Solvents-Assisted synthesis of NiFe-LDHs/Mo2Ti2C3: A bifunctional electrocatalyst for overall electrochemical water splitting in alkaline media

Article

作者: Honnappa, Brahmari ; Matheswaran Arun Kumar, Kalingarayanpalayam ; Kokulnathan, Thangavelu ; Wang, Tzyy-Jiann ; Sekar, Karthikeyan

The development of efficient and stable electrocatalysts is crucial for the advancement of green and clean hydrogen energy technologies. In this work, we synthesized a nanocomposite of nickel-iron layered double hydroxide/molybdenum titanium carbide (NiFe-LDHs/Mo₂Ti₂C₃) using a deep eutectic solvent (DESs) by the solvothermal method. The formation of NiFe-LDHs/Mo₂Ti₂C₃ nanocomposite was confirmed by various electron microscopic and spectroscopic techniques. The synthesized nanocomposite was investigated as a bifunctional electrocatalyst for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) under the alkaline condition. The NiFe-LDHs/Mo₂Ti₂C₃-based electrodes exhibit small overpotentials of 204 and 306 mV for HER and OER at a current density of 10 mA cm^-2. The anchor of NiFe-LDHs on the surface of Mo₂Ti₂C₃ induces an interfacial synergistic effect, leading to a significantly improvement in electrochemical performance. Remarkably, the proposed NiFe-LDHs/Mo₂Ti₂C₃ modified electrode demonstrates superior performance compared to many recently reported LDHs and MXenes-based electrocatalysts in an alkaline environment. Furthermore, a symmetrical two-electrode water splitting setup employing the NiFe-LDHs/Mo₂Ti₂C₃ electrocatalyst requires an electrolysis voltage of 1.65 V to achieve a current density of 10 mA cm^-2. The findings provide a new perspective on the rational design and synthesis of multifunctional electrocatalysts for electrochemical applications.

100 项与 SRM University 相关的药物交易

登录后查看更多信息

100 项与 SRM University 相关的转化医学

登录后查看更多信息