A Clinical Study on Migraine without Aura (Shaqeeqa) and its Management with Polyherbal Formulation- A Randomized Standard Controlled Clinical Trial - NIL

开始日期2024-10-21

申办/合作机构

Ayurvedic And Unani Tibbia College

CTRI/2024/10/074747 / Not yet recruiting临床2期IIT

A clinical evaluation of Dawa ul kurkum Kabir and Qurs kushta Folad in Su-al-qinya bawajah qilat Folad (Iron deficiency anemia) among women of reproductive age.

开始日期2024-10-15

申办/合作机构

Ayurvedic And Unani Tibbia College

CTRI/2024/10/074682 / Not yet recruiting临床2期IIT

A Clinical Study on Generalized Anxiety Disorder and its Managementwith a Polyherbal Unani Formulation- A Randomized Standard Controlled Clinical Trial - NIL

开始日期2024-10-10

申办/合作机构

Ayurvedic And Unani Tibbia College

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项与 Ayurvedic And Unani Tibbia College 相关的文献（医药）

2024-07-02·Journal of Biomolecular Structure and Dynamics

Repurposing phytochemicals of Citrullus colocynthis against maltase-glucoamylase using molecular docking, MMGBSA, MD simulation and linear regression to identify potential anti-diabetic compounds

Article

作者: Sahu, Parameswar ; Behera, Banshidhar ; Sahoo, Rosaleen ; Saluja, Sundeep Singh ; Sahu, Abhishek Kumar

Diabetes is a common lifestyle disorder found in populations of different age groups. Maltase-glucoamylase catalyses the release of the glucose molecule in the final enzymatic reaction of starch digestion; therefore, inhibition of maltase-glucoamylase is one of the approaches in the development of therapeutics for diabetes. Citrullus colocynthis is commonly recommended in Ayurveda for the treatment of diabetes. The current study applied a structure-based drug design approach to repurpose the phytochemicals of Citrullus colocynthis to identify potential inhibitors for maltase-glucoamylase. 70 phytochemicals of Citrullus colocynthis were screened against maltase-glucoamylase and top 5 molecules 8-p-hydroxybenzylisovitexin, isoorientin, cucurbitacin B, cucurbitacin E, and cucurbitacin I with significant binding energy of -10 kcal/mol, -9.9 kcal/mol, -9.6 kcal/mol, -9.2 kcal/mol, and -7.7 kcal/mol were identified. Furthermore, MMGBSA, pharmacokinetics properties and toxicity prediction were performed on the five identified molecules and top 3 molecules were selected for molecular dynamics (MD) simulation. It was observed from the structural flexibility and dynamic behaviour of the systems that conformational changes were noticed in the complexes as compared to its native state, which suggests that the 3 molecules, namely 8-p-hydroxybenzylisovitexin, isoorientin, and cucurbitacin I of Citrullus colocynthis may act as inhibitors for maltase-glucoamylase.Communicated by Ramaswamy H. Sarma.

2023-06-01·INDIAN JOURNAL OF APPLIED RESEARCH

AYURVEDIC MANAGEMENT OF OLIGOSPERMIA: A CASE STUDY

作者: Garg, Sahil ; Kumar Panda, Srikanta ; Kumar, Manish

The condition known as oligoasthenozoospermia occurs when the two parameters, sperm count and sperm motility, are changed. It is assessed by semen analysis and shows a decrease in the concentration and proportion of motile spermatozoa in a sperm sample. Research indicates that conditions or causes affecting male reproduction account for roughly 50% of infertility cases in India. According to a research by the WHO from 1982 to 1985 in many locations, 20% of cases of infertility are caused by male factors. About 23% of Indian couples receiving infertility treatment blamed male factors for their infertility. It is possible to correlate oligoasthenozoospermia to the Sukra kshaya Lakshanas stated in Ashta sukra dushtis. A 31-year-old man with 1.5 years of marriage was diagnosed with oligospermia, which is characterised by a low sperm count and a lack of motile spermatozoa. Shodhan (Virechan) and Shamanchikitsa demonstrated an improvement in seminal parameters following Deepan/Pachan. This demonstrates the effectiveness of Ayurvedic medicine in the treatment of male infertility.

2023-01-01·Journal of Surgical Specialties and Rural Practice

Knowledge, Attitude, and the Practice Study among the Kshar Sutra Practicing Surgeons

作者: Dixit, Ashish Kumar ; Tarique, BarkatiMd ; Dixit, AshishKumar ; Dhama, Yudhveer ; Tarique, Barkati Md. ; Javed, Danish ; Chaudhary, Praveen

Background:Kshar Sutra treatment in cases of fistula is quite common in India. We conducted a cross-sectional study among Kshar Sutra practitioners to find out knowledge, attitude, and practicing approach in the present scenario. A total of 192 participants completed this online survey through a self-administered questionnaire.Materials and Methods:Two experts assessed the content and face validity of the questionnaire. The tool was pilot-tested to validate the questionnaire and Cronbach’s alpha coefficient was calculated to assess the acceptable internal consistency before the data collection. A total of 32 questions in three domains, knowledge (6), attitude (12), and practice (14), respectively, were asked to participants. We performed linear and logistic regressions to find out the relations with respect to independent variables such as experience, nature of job, qualification, and number of surgeries performed every year by participants.Results:Knowledge was found positively related to qualification and experience significantly. Less use of analgesics and antibiotics was positively related to qualification but negatively related to experience. More cosmetic scar in postoperative cases was positively supported by more cases performing surgeons but negatively by private practitioners. Less time required for surgery was positively related to more experienced surgeons. The use of self-prepared Kshar Sutra was seen 2–6 times popular among more qualified and experienced private practitioners. Most of the surgeons were in favor of investigations and indoor admission before surgery.Conclusion:Re-orientation programs are required to conduct for Kshar Sutra surgeons and the availability of commercial Kshar Sutras is extremely demanding to fill the gap in current practice.

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