Instituto de Assistência Médica ao Servidor Público Estadual (Instituto de Assistência Médica ao Servidor Público Estadual)

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项与 Instituto de Assistência Médica ao Servidor Público Estadual 相关的临床试验

RBR-28swytb

/ Not yet recruitingN/A

Use of Dexmedetomidine as an adjuvant in Peng Block for hip surgery: randomized clinical study

开始日期2025-01-01

申办/合作机构

Instituto de Assistência Médica ao Servidor Público Estadual

[+1]

RBR-6b4zwx3

/ RecruitingN/AIIT

Effectiveness of Aerobic Training in Chemotherapy-related adverse symptoms during treatment: controlled and randomized trial with economic evaluation

开始日期2023-07-01

申办/合作机构

Universidade Cidade De Sao Paulo

[+1]

RBR-564y4n

/ RecruitingN/A

Investigation of muscle weakness, function and quality of life after Intensive Care Unit discharge in survivors of COVID-19

开始日期2020-05-20

申办/合作机构

Instituto de Assistência Médica ao Servidor Público Estadual

[+1]

100 项与 Instituto de Assistência Médica ao Servidor Público Estadual 相关的临床结果

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0 项与 Instituto de Assistência Médica ao Servidor Público Estadual 相关的专利（医药）

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143

项与 Instituto de Assistência Médica ao Servidor Público Estadual 相关的文献（医药）

2025-06-01·The Breast

CADONOT: Comparing axillary dissection or not in breast cancer surgery

Review

作者: Madeira, Marcelo ; Rondelo, Sabrina Monteiro ; Soares, Leonardo Ribeiro ; Arakelian, Renata ; Zerwes, Felipe ; Amorim, Andressa Gonçalves ; Millen, Eduardo de Camargo ; Baruel, Patrícia Carvalho ; Ramos, Marcellus do Nascimento Moreira ; Couto, Henrique Lima ; de Freitas Junior, Ruffo ; Cavalcante, Francisco Pimentel ; Brenelli, Fabricio Palermo ; Teixeira, Marina Diógenes ; Mattar, André ; Gebrim, Luiz Henrique ; Facina, Gil ; Leite, Renata Montarroyos ; Antonini, Marcelo ; Real, Juliana Monte ; Frasson, Antônio Luiz ; Okumura, Lucas Miyake ; de Oliveira, Larissa Chrispim

INTRODUCTIONSentinel lymph node biopsy (SLNB) is the gold standard for the axillary evaluation of clinically node-negative early breast cancer. The ACOSOG Z0011 study demonstrated the safety of omitting axillary dissection for limited SLNB disease, with other trials confirming SLNB alone or with axillary radiotherapy (AR) as non-inferior.METHODSWe followed PRISMA guidelines and registered at PROSPERO. Using Medline, Embase, and Cochrane, we reviewed randomized controlled trials (2010-2024). Outcomes, including 5-, 8-, and 10-year OS, DFS, recurrence rates, and lymphedema, were analyzed with R software and assessed for bias (Cochrane RoB) and evidence quality (GRADE). The focus was ALND vs. SLNB, alone or with AR, in cT1-T3 BC with 1-2 metastatic SLNs.RESULTSThirteen articles from seven randomized controlled trials (RCTs) were included, covering 7338 women with a follow-up period of 2.8-10 years. SLNB was associated with a 65 % lower risk of lymphedema than ALND, with no significant differences in the 5-, 8-, or 10-year OS, DFS, or recurrence rates. A meta-analysis comparing micrometastasis and macrometastasis showed no impact on outcomes, indicating that ALND may be unnecessary in either case. Recurrence rates also did not differ between SLNB and ALND, reinforcing SLNB's significantly lower lymphedema risk of SLNB.CONCLUSIONSThis systematic review and meta-analysis support SLNB as a safe and effective alternative to ALND in early-stage BC with 1-2 positive SLNs, providing comparable survival and recurrence outcomes, with fewer complications.

2025-04-01·Anais Brasileiros de Dermatologia

Merkel cell carcinoma coexisting with squamous cell carcinoma⋆

Article

作者: de Almeida, Mariana Abdo ; Valente, Neusa Yuriko Sakai ; Barata, Mariangela Cristina Crispino ; Curcelli, Emílio Martins ; Scabello, Bruna Nascimento Arruda

2025-01-16·Cureus

Osteosynthesis of Three- and Four-Part Proximal Humerus Fractures in Elderly Patients Using Locking Plates and Synthetic Bone Grafts: A Clinical and Radiographic Evaluation

Article

作者: Tenor Júnior, Antonio Carlos ; Neves, Rafael Segundo Ferreira ; Assunção, Jorge ; Brasil Filho, Rômulo ; Malavolta, Eduardo A ; Gracitelli, Mauro E

OBJECTIVESTo evaluate clinical and radiographic outcomes and complications of three- and four-part proximal humerus fractures (PHF) in elderly patients treated with angular locking plate (LP) combined with calcium sulfate (CaSO₄) paste graft.MATERIALS AND METHODSA prospective case series evaluating patients aged ≥ 60 years with three- or four-part PHF treated with LP and 10 ml of CaSO⁴ paste graft. Primary outcome was clinical evaluation using the Constant-Murley (CM) score at 12 months. Secondary outcomes included scores from the University of California, Los Angeles (UCLA), American Shoulder and Elbow Surgeons (ASES), Visual Analog Scale (VAS), Disabilities of the Arm, Shoulder and Elbow (DASH), bilateral active range of motion (ROM), abduction strength, Constant Relative Index (CRI), radiographic findings, and complications.RESULTSThirty patients were evaluated. At 12 months, the mean scores were: 67.7 (CM), 30.5 (UCLA), 86.5 (ASES), 0.7 (VAS), and 18.9 (DASH). The mean active ROM was 121° (flexion), 109° (abduction), 53° (external rotation), and thumb-T12, with abduction strength of 5.7 kg. The mean head-shaft angle (HSA) on the first postoperative day was 133°, with minimal change to 129° at 12 months, and the mean humeral height (HH) remained unchanged (11 mm). There were five complications in four patients (13.3%): three cases of severe varus collapse (difference between the neck-shaft angle (NSA) on the first postoperative day and the 12th month postoperative > 20°), and two cases of cutout. Two reoperations (6.0%) were performed to remove screws that had penetrated the joint.CONCLUSIONClinical and radiographic outcomes of three- or four-part PHF in elderly patients treated with LP and CaSO₄ paste graft are satisfactory, with relatively low complications and reoperation rates.

100 项与 Instituto de Assistência Médica ao Servidor Público Estadual 相关的药物交易

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100 项与 Instituto de Assistência Médica ao Servidor Público Estadual 相关的转化医学

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