Pregnant women in South Africa (SA) are at high risk of HIV acquisition. Pre-exposure prophylaxis (PrEP) use during pregnancy is both safe and effective in preventing HIV. However, posttraumatic stress (associated with intimate partner violence and/or other traumas) and depression negatively impact PrEP adherence among women in SA. Addressing posttraumatic stress and depression will likely improve PrEP adherence and persistence (i.e., sustained PrEP adherence over time) during pregnancy and breastfeeding, which are periods of dramatically increased HIV risk. The overarching goal of this proposal is to develop and test the feasibility and acceptability of a cognitive behavioral intervention that targets common underlying factors of posttraumatic stress and depression to improve PrEP adherence and persistence during pregnancy and the postpartum transition. The specific aims of the project are to (1) explore the mechanisms by which posttraumatic stress and depression impact PrEP adherence and persistence during pregnancy via qualitative interviews; (2) develop a brief PrEP adherence and persistence intervention (
4 sessions) that reduces the negative impact of psychological mechanisms common to posttraumatic stress and depression on PrEP use, and builds behavioral skills to improve self-care; and (3) evaluate the feasibility, acceptability, and signals of preliminary efficacy of the intervention, which will be integrated into antenatal care, in a pilot randomized controlled trial. All data will be collected in the Midwife Obstetrics Unit (MOU) in Gugulethu, a peri-urban settlement and former township community outside of Cape Town, SA.

开始日期2025-02-28

申办/合作机构

Winthrop University

[+2]

NCT06593847 / Not yet recruitingN/AIIT

Multisite Virtual Reality Intervention for Speech Anxiety

Exposure-based cognitive behavior therapy is an efficacious treatment for speech anxiety and has been delivered effectively in a virtual reality (VR) environment. The present multicenter study (conducted through the Exposure Therapy Consortium) is designed to evaluate whether trait versus state positive affectivity is a more effective predictor of exposure therapy outcomes. Further, the investigators will examine whether the predictive significance of trait positive affectivity can be accounted for by examination of baseline levels of self-efficacy, hope, and optimism.

开始日期2024-09-23

申办/合作机构

Winthrop University

[+11]

NCT06182241 / Not yet recruitingN/AIIT

Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South Africa: Part 2

The investigators will conduct the formative work that is necessary to develop a novel, multi-level intervention (inclusive of patient- and provider-level components), which will increase awareness of and modify the complex, intersecting factors that contribute to cervical cancer development among cisgender women with HIV (WWH). In Aim 1a, the investigators will explore the multi-level barriers and facilitators to follow-up appointment attendance among WWH who have had a recent high-risk abnormal Pap smear in the past six months, via qualitative interviews with WWH who have either attended at least one follow-up visit (n<10) or have not yet attended a follow-up visit (n<10). In Aim 1b, the investigators will explore provider awareness of the HIV-cervical cancer relationship and perspectives on barriers to retention in care via qualitative interviews (n<8). For Aim 2, The study team will leverage the Aim 1 data, develop a patient-level intervention (1-2 sessions) and a provider toolkit, with the goal of increasing retention in care among WWH who are at heightened risk for cervical cancer. The study team will seek feedback on the manual and the toolkit from providers and from a community advisory board. In Aim 3a, the investigators will test the feasibility and acceptability of the intervention in a pilot randomized control trial (RCT) (n<60). The study team will also assess (1) changes in self-efficacy to attend cervical cancer-related healthcare appointments pre-post intervention, (2) the proportion of women who attend a follow-up appointment, and, of those participants, (3) the proportion of women who complete the next phase of treatment. In Aim 3b, the investigators will explore the feasibility of intervention implementation in the clinic and acceptability of the provider-level intervention components in qualitative interviews with providers, clinic staff, the interventionalists, and other key stakeholders (n<10).

开始日期2024-09-01

申办/合作机构

Winthrop University

[+1]

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项与 Winthrop University 相关的文献（医药）

2024-11-01·Reading & Writing Quarterly

Reading Inside Out: A Resilience-Driven Mentoring Approach to Enhancing Reading Fluency for at-Risk Students of Color

作者: Mize, Min ; Park, Yujeong ; Ferguson, Shea

2024-11-01·Letters in Organic Chemistry

Synthesis of Symmetrical and Unsymmetrical Tetrahydroxybiphenyls and their Evaluation as Amyloid-β Aggregation Inhibitors

作者: Wicks, Sarah L. ; Murray, Mouskudah G. ; Lammi, Robin K. ; Taylor, Andrea L. ; Stevens, Craig B. ; Hanna, James M. ; Roberts, Jake A. ; Jones, Jason J. ; Logan, Jessica K. ; Schreiber, William J. ; Crenshaw, Brandy L. ; Hernandez, Benjamin P. ; Hurtt, Matthew J.

Abstract:Our group recently reported that the polyhydroxy aromatic compound 3,3′,4,4′- biphenyltetrol (2a) is a successful inhibitor of amyloid-β peptide (Aβ) aggregation, decreasing Aβ aggregation by 50 % when present in equimolar concentrations. In the present study, several additional biphenyltetrols were prepared and examined for their in vitro activity against aggregation of Aβ to investigate the effect of the relative positions of hydrogen-bond donors on the aggregation process. Congo red spectral shift assays demonstrated that, of the eight (8) additional biphenyltetrol compounds prepared, three (3) successfully inhibited the association of Aβ monomers, two symmetrical isomers, 2,2′,5,5′-biphenyltetrol (2c), and 2,2′,3,3′-biphenyltetrol (2d), along with one unsymmetrical isomer, 2,3′,4′,5-biphenyltetrol (2g). These results, along with the previously reported results of 2a, strongly suggest that hydroxyl group position affects the ability of the inhibitor to bind to Aβ assemblies, thus impacting inhibitory efficacy.

2024-09-03·Evolutionary Computation

Preliminary Analysis of Simple Novelty Search

Article

作者: Wiegand, R. Paul

AbstractNovelty search is a powerful tool for finding diverse sets of objects in complicated spaces. Recent experiments on simplified versions of novelty search introduce the idea that novelty search happens at the level of the archive space, rather than individual points. The sparseness measure and archive update criterion create a process that is driven by a two measures: (1) spread out to cover the space while trying to remain as efficiently packed as possible, and (2) metrics inspired by k nearest neighbor theory.In this paper, we generalize previous simplifications of novelty search to include traditional population (μ,λ) dynamics for generating new search points, where the population and the archive are updated separately. We provide some theoretical guidance regarding balancing mutation and sparseness criteria and introduce the concept of saturation as a way of talking about fully covered spaces. We show empirically that claims that novelty search is inherently objectiveless are incorrect. We leverage the understanding of novelty search as an optimizer of archive coverage, suggest several ways to improve the search, and demonstrate one simple improvement—generating some new points directly from the archive rather than the parent population.

项与 Winthrop University 相关的新闻（医药）

2023-11-27

·PRNewswire

The Inner Circle Acknowledges, Josel Doyle as a Pinnacle Platinum Healthcare Professional for her contributions to Neonatology

TOPEKA, Kan., Nov. 27, 2023 /PRNewswire/ -- Prominently featured in The Inner Circle, Josel Doyle is acknowledged as a Pinnacle Platinum Healthcare Professional for her contributions to Neonatology. Dr. Doyle pursued higher education at St. Georges University School of Medicine, earning undergraduate and medical degrees. She completed a residency in pediatrics at Winthrop University and a fellowship in neonatal-perinatal medicine at Stonybrook University Hospital. Recognized for her leadership early in her career, she also served as Chief Resident at Stony Brook University Hospital. Continue Reading Josel Doyle Dr. Doyle currently works at Pediatrix Neonatology of Topeka, where she and her team, all board-certified neonatologists and certified neonatal nurse practitioners (NNPs), care for premature and critically ill newborns. She has provided services at StormontVail Healthcare Level III NICU and Kansas University St. Francis campus Level II NICU in Topeka since 2015. Dr. Doyle explained that neonatology is a subspecialty of pediatrics that consists of the medical care of newborn infants, especially ill and premature newborns. It is a hospital-based specialty usually practiced in neonatal intensive care units. She said that neonatologists generally diagnose and treat newborns with conditions such as breathing disorders, infections, and congenital disabilities, as well as coordinating care and medically managing newborns born prematurely, critically ill, or in need of surgery. Dr. Doyle is dedicated and passionate about providing the latest advancements in her field, and her clinical interests include neonatal nutrition, developmental outcomes, and respiratory distress syndrome, all essential components of the care of premature and critically ill infants. She also specializes in providing transportation services to neighboring hospitals needing advanced care for the most critical infants requiring specialized neonatal services. She is a member of numerous professional organizations, including the American Academy of Pediatrics, the Kansas Perinatal Collaborative on Neonatal Abstinence Syndrome (NAS), and Stormont Vail Hospitals NAS task force, where she helps to develop policies and practices aimed at improving the care of infants affected by substance use disorders. The doctor is highly sought after for her skills and leadership abilities. As such, she is also on Stormont's Family-Centered Care Committee and serves on the NICU Developmental and Relationship Committee. Dr. Doyle is the visionary Founder of JAAD's Purpose movement, which extends far beyond traditional boundaries and embraces medical care, consulting, and practitioner education to save lives. Through a powerful blend of compassion, expertise, and steadfast dedication, JAAD's Purpose truly impacts lives. When considering her achievements during her career, Dr. Doyle credits her faith in God and her parents for instilling in her a strong sense of purpose and the values of hard work, compassion, and dedication. She notes that her love for the profession has been a driving force in her success. She is deeply committed to providing the best possible care to her patients and is constantly seeking new ways to improve outcomes and enhance the patient's experience. Her website: Contact: Katherine Green, 516-825-5634, [email protected] SOURCE The Inner Circle

高管变更

2021-08-23

·GlobeNewswire

Sharonview Federal Credit Union Promotes VP of Risk Management

Indian Land, S.C., Aug. 23, 2021 (GLOBE NEWSWIRE) -- Casey Munn has been promoted to Vice President of Risk Management at Sharonview Federal Credit Union, one of the nation’s top 200 credit unions. In this role, Munn will be responsible for identifying, assessing and managing Sharonview’s operational, financial and strategic risks. He will ensure Sharonview has a strong compliance culture and is taking the necessary steps to remain safe and observe all regulatory requirements. Munn joined Sharonview in February 1996 and has held many roles within the company, including mortgage loan underwriter, mortgage loan manager, loan operations manager, vice president of loan operations, vice president of real estate lending and compliance officer. His breadth of experience with Sharonview makes him the ideal candidate for his new role. He earned his Bachelor of Science Degree in Finance and Management from the University of South Carolina and his Master in Business Administration Degree from Winthrop University. He also holds professional certifications in Compliance, BSA/AML (Bank Secrecy Act/Anti-Money Laundering) and Risk Management. Originally from Rock Hill, South Carolina, Munn continues to live in his hometown with his wife, Shannon. They have two children: Ashley, 24, and Ryan, 19. When not working, he enjoys running, golf, movies and is an avid college sports fan. ### About Sharonview Federal Credit Union Sharonview Federal Credit Union, voted in 2018 the No.1 credit union in South Carolina by Forbes, is headquartered in Indian Land, South Carolina, and has been serving its members since 1955. Today, Sharonview serves over 100,000 members nationwide, has assets totaling more than $1.7 billion and operates 19 branches in North Carolina and South Carolina. It is also ranked as one of the top 200 credit unions in the country, proving its dedication to providing its members with a full array of value-added financial services, all of which are backed by the United States government and federally insured by the National Credit Union Administration. Sharonview currently stands above the crowd in delivering the personal touch, providing loans with fewer restrictions, flexible terms and lower rates. For more than 65 years, Sharonview has promised exceptional value and delivered financial services members can trust, with us it’s personal. For more information on Sharonview Federal Credit Union: . Attachment

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