The methods for determination of schizandrol A in Hu Gan capsules were established.Schizandrol A was extracted by methanol soxhlet, methanol ultrasonic extraction and Et acetate reflux.Schizandrol A was determined by high-performance liquid chromatog.A Ajilent C18 column (250 mm×4.6 mm) was used with the mobile phage of acetonitrile-water (50:50), flow rate was 0.1 mg/mL, and detection wavelength was at 250 nm.There were good linear relationships between the peak area and concentration (r=0.9999, n=6), and linear range was 58-2,320 μg/mL.Recovery of schizandrol A was above 98% with RSD of 1.39% (n=9).The method was accurate and could be used for quality control for the preparation