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概览

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

5-HT1A receptor x 5-HT2C receptor	1

关联

1

项与 Centre européen de recherches Mauvernay 相关的药物

Oxaflozane

奥沙氟生

靶点

5-HT1A receptor x 5-HT2C receptor

作用机制

5-HT1A receptor调节剂 [+1]

在研机构

Centre européen de recherches Mauvernay

原研机构

Centre européen de recherches Mauvernay

在研适应症

抑郁症

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期1988-01-18

100 项与 Centre européen de recherches Mauvernay 相关的临床结果

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0 项与 Centre européen de recherches Mauvernay 相关的专利（医药）

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11

项与 Centre européen de recherches Mauvernay 相关的文献（医药）

Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales

Ricin-induced hyperthermia. Pharmacodynamic interest

作者: Hache, J. ; Duchene-Marullaz, Pierre ; Delort, P. ; Artigas, M.

Ricin (20 γ/kg., s.c.) induced a progressive and reproducible increase in the temperature of rats after a latent period of 3.5 hrs.; after 6 hrs. the body temperature remained at a constant high level.Antipyretic agents, such as aspirin (125-500 mg./kg.), phenacetin (62.5-250 mg./kg.), novaminsulfone (62.5-250 mg./kg.), and aminopyrine (62.5-250 mg./kg.), administered orally to rats 6 hrs. after injection of ricin, exhibited sharper antipyretic effects in these animals than in rats given only saline.The use of ricin-treated animals in assaying for antipyretic agents was suggested.The hypothermic compound chlorpromazine (10 mg./kg., orally) produced similar effects in both ricin and saline-treated rats.

Therapie

Alterations of coronary venous blood ammonia levels after treatment with some vasodilators

作者: Cosnier, D. ; Duchene-Marullaz, Pierre ; Talvard, J.

The direct and metabolic effects involved in coronary vasodilation were considered and the effects of vasodilators on the levels of O, NH3, and CO2 in blood were determinedI.v. injection of heptaminol-HCl (10 mg./kg.) into chloralosed dogs increased the coronary venous blood NH3 level by 65%, and the CO2 level by 9%, and decreased the pO2 value by 35%.Adrenaline (i.v. perfusion of 2 μg./kg./min. for 5 min.) increased the NH3 level by 27% and the COs level by 9%, and decreased the pO2 value by 7%; isoprenaline (2 μg./kg./min. for 5 min.) had a similar effect on the 3 parameters, changing them by +7, +2, and -8%, resp.Aminophylline (i.v. injection of 10 mg./kg.) also increased the total venous CO2 and NH3 levels by 5 and 21%, resp., and decreased the pO2 value by 7%, while papaverine (2 mg./kg.) increased these 3 parameters by 4, 53, and 29%, resp.I.v. injected Persantin (1 mg./kg.) increased the pO2 value by 79% and decreased the CO2 and NH3 levels by 13 and 7%, resp.

Pharmacien Fr.

Placebos

作者: Mauvernay, Roland Y. ; Stevenard, Monique

A review of actions and reactions (resistance, sensitivity) of placebos, their use in exptl. techniques, and in therapy is given.59 references.

100 项与 Centre européen de recherches Mauvernay 相关的药物交易

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100 项与 Centre européen de recherches Mauvernay 相关的转化医学

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