Delving into the Latest Updates on 合肥师范学院 with Synapse

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疾病领域	数量

感染	2

排名前五的药物类型	数量

合成多肽	2

关联

2

项与合肥师范学院相关的药物

HJH-6

靶点-

作用机制-

在研机构

合肥师范学院

原研机构

合肥师范学院

在研适应症

细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

HJH-5

靶点-

作用机制-

在研机构

合肥师范学院

原研机构

合肥师范学院

在研适应症

细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

1

项与合肥师范学院相关的临床试验

ChiCTR2400093921

/ Suspended临床1期IIT

Effect of intermittent hypoxia training combined with intermittent fasting on executive function and BDNF expression in overweight or obese college students

开始日期2025-01-01

申办/合作机构

合肥师范学院

100 项与合肥师范学院相关的临床结果

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0 项与合肥师范学院相关的专利（医药）

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2,168

项与合肥师范学院相关的文献（医药）

2025-09-01·Journal of Environmental Sciences

A new perspective on the simultaneous removal of nitrogen, tetracycline, and phosphorus by moving bed biofilm reactor under co-metabolic substances

Article

作者: Wang, Minghui ; Shao, Sicheng ; Gao, Qijuan ; Zhu, Fang

With the burgeoning growth of aquaculture industry, high concentration of NH₄⁺-N, phosphorus and tetracycline are the prevalent pollutants in aquaculture wastewater posing a significant health risk to aquatic organisms. Therefore, an effective method for treating aquaculture wastewater should be urgently explored. Simultaneous removal of NH₄⁺-N, phosphorus, tetracycline, and chemical oxygen demand (COD) in aquaculture wastewater was developed by moving bed biofilm reactor (MBBR) under co-metabolic substances. The result showed that co-metabolism substances had different effects on MBBR performance, and 79.4 % of tetracycline, 68.2 % of NH₄⁺-N, 61.3 % of total nitrogen, 88.3 % of COD, and 38.1 % of total phosphorus (TP) were synchronously removed with sodium acetate as a co-metabolic carbon source. Protein (PN), polysaccharide (PS), and electron transfer system activity were used to evaluate the MBBR performances, suggesting that PN/PS ratio was 1.48, 0.91, 1.07, 3.58, and 0.79 at phases I-V. Additionally, a mode of tetracycline degradation and TP removal was explored, and the cell apoptosis was evaluated by flow cytometry. The result suggested that 74 %, 83 %, and 83 % of tetracycline were degraded by extracellular extracts, intracellular extracts, and cell debris, and there was no difference between extracts and non-enzyme in TP removal. The ratio of viable and dead cells from biofilm reached 33.3 % and 7.68 % with sodium acetate as a co-metabolic carbon source. Furthermore, Proteobacteria and Bacteroidetes in biofilm were identified as the dominant phyla for tetracycline and nutrients removal. This study provides a new strategy for tetracycline and nutrients removal from aquaculture wastewater through co-metabolism.

2025-08-01·Journal of Biotechnology

Genome mining of an endophytic natural yeast isolate Rhodotorula sp. Y090 and production of the potent antioxidant ergothioneine

Article

作者: Zhang, Feng-Li ; Li, Jun ; Chen, Chao ; Zou, Yue ; Li, Yu-Zhen ; Cheng, Cheng ; Zhao, Xin-Qing ; Wang, Qi

Endophytic yeast strains are promising sources of various valuable bioactive compounds. However, studies on endophytic strains derived from lichen samples remain limited. In this study, we isolated and characterized Rhodotorula sp. Y090 from a Usnea longissima lichen sample, and investigated its biosynthetic potential. Genome mining revealed distinct genetic features that differed from its closest relative strain R. graminis WP1. Ergothioneine (EGT) is a potent antioxidant and rare sulfur-containing histidine derivative. However, so far, the EGT biosynthetic enzymes by natural yeast strains have been limitedly studied. In this study, combining genome mining and transcriptomic analysis, genes encoding the potential enzymes for the production of EGT and xylose utilization were identified in Rhodotorula sp. Y090. Further studies demonstrated that Rhodotorula sp. Y090 was capable of producing EGT using xylose, glucose, glycerol, or sucrose as the sole carbon source, and the highest titer reached 363.6 mg/L in shake flask culture, which is significantly higher than that of the most reported levels in the other natural yeasts. Rhodotorula sp. Y090 also exhibited a good ability of EGT export, which could facilitate cost-effective production. These findings suggest that the lichen-derived endophytic yeast Rhodotorula sp. Y090 represents a promising natural candidate for bio-production of the potent antioxidant.

2025-08-01·Food Chemistry

Comparison of the effects of three different fungal laccases on the quality of rye bread

Article

作者: Wang, Jingjing ; Gao, Yuan ; Guan, Jiaxin ; Zhang, Ran ; Zhu, Guilan ; Chen, Zifan ; Zhou, Peng ; Zhang, Yan ; Li, Jun ; Zhou, Lulu ; Fang, Zemin ; Li, Ying ; Wang, Wei

Rye bread is recognized for its high nutritional value but faces challenges such as sticky dough and an inelastic texture. Laccase, a green biological enzyme, can modify the key components of wheat and gluten-free flour products, showing promise in improving their quality. However, the use of fungal laccase on rye bread has not yet been explored, and the potential effects of different sources of fungal laccase on improving rye bread quality remain unexamined. This study comprehensively analyzed the effects of three fungal laccases on rye bread using multidimensional evaluation methods. The results indicated that each laccase had distinct effects on dough properties, with the acid laccase rLacA showing the most significant impact. This research confirmed the role of fungal laccase in enhancing the quality of rye bread and effectively evaluated the mechanisms of different fungal laccases. Additionally, it provided a foundation for developing new combinations to improve rye bakery products.

100 项与合肥师范学院相关的药物交易

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100 项与合肥师范学院相关的转化医学

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