更新于：2024-11-01

Hospital Nacional Arzobispo Loayza

私营公司|

Peru

私营公司|

Peru

更新于：2024-11-01

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项与 Hospital Nacional Arzobispo Loayza 相关的临床试验

NCT06054269 / Active, not recruiting临床3期IIT

Randomized Controlled Trial, Double Blind, Phase III, to Evaluate the Immunogenicity of an Adjuvanted Influenza Vaccine Among Health Care Personnel (EDUCATE)

This randomized, double-blinded trial will assess humoral immune responses to adjuvanted, egg-based quadrivalent influenza vaccines compared to standard dose, egg-based quadrivalent influenza vaccines among healthcare personnel (HCP). The trial will be conducted at two sites in Lima, Peru during 2022 and 2023.

开始日期2022-11-04

申办/合作机构

Centers for Disease Control & Prevention

[+3]

NCT05522296 / CompletedN/AIIT

Break-through Infection Following Mpox vaccinatIon: Target Trial Emulation

The purpose of this study is to assess the protection of smallpox preexposure vaccination against infection with mpox in real-world individuals with risk factors for mpox.

开始日期2022-09-12

申办/合作机构

Hospital Nacional Arzobispo Loayza

[+7]

NCT04526821 / Terminated临床2期IIT

Bovine Lactoferrin for the Prevention of COVID-19 Infection in Physicians and Nurses in Hospitals in Lima, Peru: a Double Blinded Randomized Clinical Trial (LF-COVID)

Clinical trial in health care personnel (physicians, nurses or nurse assistants) to determine the effect of orally-administered bovine lactoferrin to prevent SARS-CoV-2 infection. Participants will be randomized to receive daily bovine lactoferrin plus standard measures during 12 weeks or placebo (maltodextrine) for the prevention of SARS-CoV-2. The target enrollment is 336 participants. Each study participant will be monitored twice a week for symptoms of COVID-19 and if symptoms occur, a RT-PCR will be performed. Additionally, we will evaluate asymptomatic infections, by measuring SARS-CoV-2 serology every 4 weeks.

开始日期2020-10-17

申办/合作机构

Universidad Peruana Cayetano Heredia

[+1]

100 项与 Hospital Nacional Arzobispo Loayza 相关的临床结果

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0 项与 Hospital Nacional Arzobispo Loayza 相关的专利（医药）

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425

项与 Hospital Nacional Arzobispo Loayza 相关的文献（医药）

2024-07-01·Revista de Gastroenterología de México (English Edition)

Percutaneous cholangioscopy utilizing SpyGlass Discover for difficult-to-treat choledocholithiasis in an altered anatomy: A case report

Article

作者: Aliaga-Ramos, J ; Celedonio-Campos, W ; Reyes-Mugruza, T ; Sánchez-Cerna, V ; Araujo-Almeyda, G

2024-06-01·American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

Latin American Trans‐ancestry INitiative for OCD genomics (LATINO): Study protocol

Article

作者: Prieto, María Belén ; Ramsey, Kesley A ; Rancourt, Diana ; Grice, Dorothy E ; Halvorsen, Matthew W ; Gadad, Bharathi S ; Núñez Bracho, Belinda E ; Paz Y Mino, Mariel ; Fontenelle, Leonardo F ; Ferreira, Gabriela M ; Atkinson, Elizabeth G ; Alves, Gustavo S ; Crowley, James J ; Saraiva, Leonardo C ; Mattheisen, Manuel ; Quarantini, Lucas C ; Borda, Tania ; Castano, Laura Marcela Barón ; Ortega, Iliana ; de Los Angeles Matos, Maria ; Zoghbi, Anthony W ; Gonzalez-Barrios, Polaris ; Jimenez Reynolds, Alexandra Z ; Soileau, Keaton J ; Mithani, Sara M ; Munoz, Macarena Churruca ; Morales-Rivero, Alonso ; Marques, Andrea H ; Delage, Fernanda Z ; Irreño-Sotomonte, Jonathan ; Ancalade, NaEshia ; Fazio, Tomas ; Rodriguez, Carolyn I ; Ramos, Vanessa R ; Moya, Pablo R ; Garrison, Sheldon R ; Guttfreund, Daniel G ; Hovey, Joseph D ; Luna, Elba S ; Olavarria Castaman, Luis A ; Del Río, Daniela ; Gonzalez, Laura D ; Callahan, Jennifer L ; Schweissing, Ethan J ; Timpano, Kiara R ; Quiroz, Pamela Claisse ; Núñez Bracho, Ambar A ; Comer, Jonathan S ; Vallejo-Silva, Alexie ; Weinzimmer, Saira A ; Huang, Hailiang ; Martinez, Guadalupe Vidal ; de Oca, Circe Montes ; Moyano, María Beatriz ; Placencia, Maritza ; Knutsen, Madison A ; Riemann, Bradley C ; Ferrão, Ygor A ; González, Andres ; Sampaio, Aline S ; Martinez Mallen, Mayra C ; Lozada Martinez, David A ; Shavitt, Roseli G ; Costa, Daniel L ; Minaya, Charlene ; Ruiz-Chow, Angel A ; Lujambio, Joali Alexandra Juárez ; Lázaro-Muñoz, Gabriel ; de la Rosa-Gómez, Anabel ; Cruz, Victor O ; Daza, Luisa F ; Nicolini, Humberto ; Ray, Elise V ; Cuevas, Vissente Tapia ; Zai, Gwyneth ; Anderberg, Jacey L ; Duarte, Tania Pérez ; Muñoz, Sandra I ; Schneider, Sophie C ; Crosbie, Jennifer ; Ruiz-Velasco, Alejandra ; Longhurst, Melanie O ; Guzick, Andrew G ; Zapata-Restrepo, Lina M ; Best, John R ; Figueroa, Edith G ; Giusti-Rodriguez, Paola ; Yanez, Mauricio A ; Janssen-Aguilar, Reinhard ; Moreira-de-Oliveira, Maria E ; Martinez-Gonzalez, Karen G ; Perales Orellana, Jose L ; Quarantini-Alvim, Yana ; Jensen, Matias ; Sagarnaga, Melisa N ; Arnold, Paul D ; Ayton, Daphne M ; Alves, Gilberto S ; Guintivano, Jerry ; Peregrina, Tamara ; Lima, Monicke O ; Stumpf, Bárbara Perdigão ; Zepeda-Burgos, Raquel M ; Patrick, Ainsley K ; Stewart, S Evelyn ; Arellano Espinosa, Alejandro A ; Pereira, Stacey ; Patel, Darpan I ; Kook, Minjee ; Lack, Caleb ; Miguel, Euripedes C ; Rosario, Maria C ; Abramowitz, Jonathan S ; Fragoso, Daniele T H ; Wiese, Andrew D ; Storch, Shaina B ; Chire, Jessica M ; Cobite, Journa ; Martinez, Molly S ; Ramos, Iaroslava C ; Cepeda, Sandra L ; Storch, Eric A ; Forero, Diego A ; Dager, Guillermo ; Seligman, Laura D ; Frederick, Renee M ; Pato, Michele T ; Carneiro, Maria Cecília B ; Ochoa-Panaifo, Marcos E ; Richter, Margaret A ; Lanzagorta, Nuria ; Menezes, Gabriela ; Strouphauer, Emily R ; González, Marco A ; Balmaceda, Trinidad Olivos ; Aguirre, Cinthia ; Rojas, Maria Corina Ochoa ; Miño, Tomás ; McGuire, Joseph F ; Zappa, Luz M ; Dreher, Carolina B ; Ruggero, Camilo J ; Maye, Caitlyn E ; Piacsek, Kelly L ; Cappi, Carolina ; Vargas-Medrano, Javier ; Fay, Lucila ; Burton, Christie L ; Naqqash, Zainab ; Rivas, Juan C ; Barrera, Cynthia N ; Morris, Olivia J ; Buxbaum, Joseph D ; Khalfe, Nasim ; Vásquez, María I ; Goodman, Wayne K ; Berardo, María Celeste ; Chazelle, Evelyn ; Schachar, Russell J ; Adorno, Victor R ; la Garza, Beatriz Treviño-de ; Berrones, Dayan ; Barbosa, Izabela G ; Ramos, Renato T ; Bigdeli, Tim B

AbstractObsessive‐compulsive disorder (OCD) is a debilitating psychiatric disorder. Worldwide, its prevalence is ~2% and its etiology is mostly unknown. Identifying biological factors contributing to OCD will elucidate underlying mechanisms and might contribute to improved treatment outcomes. Genomic studies of OCD are beginning to reveal long‐sought risk loci, but >95% of the cases currently in analysis are of homogenous European ancestry. If not addressed, this Eurocentric bias will result in OCD genomic findings being more accurate for individuals of European ancestry than other ancestries, thereby contributing to health disparities in potential future applications of genomics. In this study protocol paper, we describe the Latin American Trans‐ancestry INitiative for OCD genomics (LATINO, https://www.latinostudy.org). LATINO is a new network of investigators from across Latin America, the United States, and Canada who have begun to collect DNA and clinical data from 5000 richly phenotyped OCD cases of Latin American ancestry in a culturally sensitive and ethical manner. In this project, we will utilize trans‐ancestry genomic analyses to accelerate the identification of OCD risk loci, fine‐map putative causal variants, and improve the performance of polygenic risk scores in diverse populations. We will also capitalize on rich clinical data to examine the genetics of treatment response, biologically plausible OCD subtypes, and symptom dimensions. Additionally, LATINO will help elucidate the diversity of the clinical presentations of OCD across cultures through various trainings developed and offered in collaboration with Latin American investigators. We believe this study will advance the important goal of global mental health discovery and equity.

2024-04-20·SLEEP

0725 Phenotyping Obstructive Sleep Apnea in Latin American Women: The Latin American Sleep Network (LATAM Sleep Net)

作者: Herrera, Edwin ; Labarca, Gonzalo ; Bettancourt, Eddy ; Maquilon, Cesar ; Zuniga, Carlos ; Rojas, Stephanie ; Perez-chada, Daniel ; Nieto, Joaquin ; Larrateguy, Luis ; de Castro, Jorge Rey ; Nunez, Jimena ; Che, Jose Luis ; Retamal, Eva ; Bazuarto, Maria Angelica ; Jorquera, Jorge ; Henriquez-beltran, Mario ; Gutierrez, Angela ; Saad, Romina ; Vargas, Leslie ; Saldias, Fernando

AbstractIntroductionObstructive Sleep Apnea (OSA) is a major cardiovascular risk factor and has worse health outcomes. Novel OSA-driven metrics have been associated with worse outcomes. However, data on women from unrepresentative groups, such as the Hispanic/Latino population outside the USA, is scant. This study aims to quantitatively describe the clinical and novel OSA-driven phenotypes among women from Latin America.MethodsWe performed a prospective, multicenter study including women with suspected OSA from 18 sleep clinics in 8 countries (Argentina, Bolivia, Chile, Colombia, Costa Rica, Mexico, Peru, and Uruguay). We extracted the raw data from the baseline sleep study from October 2022 to December 2023. To determine 1). Sleep Apnea Specific hypoxic burden (SASHB) is defined as the total area under respiratory event-related desaturation curves; 2) Specific Heart Rate Response (ΔHR), defined as the difference between a maximum heart rate during a subject-specific search window and an event-related minimum heart rate; 3) Ventilatory burden, defined as the event-specific area under the ventilation signal, identified by amplitude changes in the nasal pressure signal; and 4) Desaturation sensitivity (i.e., the tendency to desaturate) was defined as a hypoxic burden divided by a ventilatory burden.ResultsA total of 318 women were included 26% non-OSA, 38% mild OSA, and 36% moderate to severe OSA). The average AHI3% was 16.5 ev/hr, SASHB was 43.4%min/hr; VB was 244.3 %eupnea*min/h; ΔHR was 8.2 bpm, and the desaturation sensitivity was 0.16. Among OSA patients, the AHI3% was 21.78 ev/hr; SASHB was 57.8 %min/hr; VB was 338.1 %eupnea*min/h; ΔHR was 8.14 bpm, and the desaturation sensitivity was 0.18. Based on high SASHB (≥ 60%min/hr) or high ΔHR (≥ 10 bpm), 19% and 26% of the sample are at risk of worse cardiovascular outcomes, respectively, and 7.4% of the sample reported both criteria associated with adverse outcomes.ConclusionAmong OSA women from Latin America, OSA-physiologically driven metrics are reproducible and similar to previous publications. Further studies are needed to fully understand the clinical utility of these metrics in clinical practice. Study register ISRCTN11936746.Support (if any)The Chest /AASM (7868 ); NIH(1R21HL161766-01); SRS (07-SRG-22); Universidad de Concepcion(2022000589)

100 项与 Hospital Nacional Arzobispo Loayza 相关的药物交易

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100 项与 Hospital Nacional Arzobispo Loayza 相关的转化医学

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