A Randomized, placebo-controlled study to assess the efficacy & safety of the combination of Berberis aristata and Phyllanthus emblica extract supplementation in prediabetic subjects. - NIL

开始日期2024-06-10

申办/合作机构

Pharmanza Herbal Pvt Ltd.

CTRI/2023/07/055436

/ Not yet recruitingN/A

Clinical Pharmacokinetic Study of Standardized Crocus sativus Extract Capsules in Healthy Human Volunteers - Nil

开始日期2023-07-30

申办/合作机构

Pharmanza Herbal Pvt Ltd.

CTRI/2023/06/053380

/ Not yet recruitingN/A

â??A randomized controlled trial to assess the effect of curcumin and amla containing ointment on PICC related contact dermatitis in patients receiving chemotherapy at TMH Mumbaiâ??

开始日期2023-06-30

申办/合作机构

Pharmanza Herbal Pvt Ltd.

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项与 Pharmanza Herbal Pvt Ltd. 相关的文献（医药）

2025-08-01·Food Chemistry

Machine learning-guided Orbitrap-HRAMS-based metabolomic fingerprinting for geographical origin, variety and tissue specific authentication, and adulteration detection of turmeric and ashwagandha

Article

作者: Rakwal, Poonam ; Rathor, Priya ; Rai, Abhishek Kumar ; Khan, Samreen ; Hinghrani, Lal ; Mukhopadhyay, Pradipto ; Verma, Anoop Kumar ; Trivedi, Prabodh Kumar ; Birse, Nicholas ; Trivedi, Ritu ; Ratnasekhar, C H

The increasing global demand for herbs and spices in food and nutraceutical industries highlights their key functional benefits, including antioxidant and anti-inflammatory properties. Ensuring authenticity and traceability is essential to counteract challenges such as geographical origin (GO) mislabelling and tissue- or variety-specific adulteration, which can undermine product quality and safety. This study employs LC-Orbitrap-MS-based untargeted metabolomics coupled with machine learning to authenticate the GO, variety, and tissue specificity of turmeric (Curcuma longa) and ashwagandha (Withania somnifera), two widely used food ingredients. Four GO-specific turmeric samples, three tissue- and variety- specific ashwagandha samples, and adulterated market samples were analysed using data-dependent acquisition mode. Machine learning algorithms identified key biomarkers and constructed robust classification models, achieving 98 % specificity and accuracy in authenticating GO, variety, and tissue specificity, even in adulterated samples. These results demonstrate the value of integrating advanced metabolomics and machine learning for quality assurance and food safety in the global market.

2025-04-14·Current Functional Foods

Plant-Based Carotenoids: An Insightful Review of Their Chemistry, Extraction, And Analysis

作者: Hingorani, Lal ; Mulay, Vallabh ; Saste, Ganesh ; Bhatt, Ankit ; Girme, Aboli ; Kureshi, Azazahemad A.

Carotenoids are a major class of natural pigments widely found in chloroplasts or chromoplasts of plants (fruits, flowers, and vegetables), fungi, algae, and bacteria. In the past few decades, researchers have explored carotenoids from various sources and determined their structures using different analytical tools. Owing to a wide range of health benefits, carotenoid-based food supplements have emerged as an excellent option for nutraceutical and food indus-tries. Carotenoids are a class of plant pigments involved in light absorption during photosyn-thesis. They also protect chlorophylls from oxidative stress and damage caused by reactive oxygen species (ROS). However, standardizing these molecules in botanicals is extremely challenging due to their poor stability against numerous environmental factors such as temper-ature, light, air, and oxygen. This review article describes chemistry and classification, the health benefits of various plant-based carotenoids and biosynthesis. Extraction of carotenoids plays a crucial role in standardization; various modern (green) techniques, microwave-assisted extraction (MAE), ultrasound-assisted extraction (UAE) supercritical fluid extraction (SFE), have been discussed in this review. The recent concepts of extracting carotenoids using deep eutectic solvents (DES), and ionic liquid (IL) have also been covered. Along with that, the review is more focused on the identification and characterization of carotenoids in dietary bo-tanicals, extraction techniques, sample stability, and analytical techniques for qualitative and quantitative analysis of carotenoids. Detailed information on liquid chromatographic tech-niques, HPLC, LC-MS, and HPTLC has been summarized in this review. In this context, the future prospects of carotenoids have also been included in this review.

2025-03-01·Chromatographia

Isolation and Purification of Isoflavones and Isoflavone Glycosides from Dalbergia sissoo Leaves and In silico Evaluation for Anti-aging Potential

作者: Trivedi, Ritu ; Hingorani, Lal ; Saste, Ganesh ; Balasubramaniam, Arun Kumar ; Mulay, Vallabh ; Modi, Siddharth J.

Dalbergia sissoo Roxb., rich in isoflavones and isoflavone glycosides, is widely used to treat osteogenic effects, pain, and other diseases.This study employed simple procedures based on preparative reversed-phase high-pressure liquid chromatog. (prep-RP-HPLC) for large-scale isolation of isoflavones and isoflavone glycosides present in Dalbergia sissoo leaves (DSL).The seven compounds were isolated from the ethanolic extract by the preparative HPLC-PDA method, and their purity was > 95%.The authors carried out an in silico anal. to find possible anti-aging compoundsIsolated compounds biochanin-A-7-O-β-Dapiofuranosyl-(1-5)-β-D-apiofuranosyl-(1-6)-β-D-glucopyranoside DS2 and biochanin-A-7-O β-D-apiofuranosyl-(1-6)-β-D-glycopyranoside DS3 demonstrated docking scores of -10.466 and -9.430 with docking energies of -81.864 and -77.531 kcal/mol, resp., to the Hyaluronidase enzyme.For the Collagenase enzyme, they showed docking scores of -10.734 and -10.777 with docking energies of -107.102 and -98.317 kcal/mol, resp.Against the Tyrosinase enzyme, Compounds DS2 and DS3 had docking scores of -7.333 and -7.993 with docking energies of -59.933 and -84.825 kcal/mol, resp.For the elastase enzyme, they exhibited docking scores of -9.840 and -7.993 with docking energies of -68.490 and -84.815 kcal/mol, resp.This study found that the isolation and purification method is simple and produces neat chromatograms with good selectivity and reproducibility.At the same time, docking results revealed that the compounds exhibited anti-aging properties.

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