Delving into the Latest Updates on Max Zeller Söhne AG with Synapse

概览

排名前五的药物类型	数量

中药	1

关联

1

项与 Max Zeller Söhne AG 相关的药物

Zeller Entspannung film coated tablet

靶点-

作用机制-

在研机构

Max Zeller Söhne AG

原研机构

Max Zeller Söhne AG

在研适应症

心理压力

非在研适应症-

最高研发阶段批准上市

首次获批国家/地区-

首次获批日期-

9

项与 Max Zeller Söhne AG 相关的临床试验

NCT05684523 / Completed临床4期

Feasibility Study on the Use of Redormin® 500 (Ze 91019) on Day-time Cognition and Quality of Life in People With Occasional Sleep Problems

Randomized, double-blind, parallel groups, placebo-controlled, baseline/run-in period of 21 days followed by trial period of 21 days, digital phenotyping (sleep, cognitive/psychological parameters and HRV).
The aim of this study is to determine the feasibility of investigating the effects of Redormin® 500 on day-time cognition and to assess psychological parameters (subjective cognitive performance, tiredness, mood, stress level, quality of life, motivation), in people with occasional sleep problems.
Sleep tracking data will be collected using consumer devices of the Charge series by Fitbit.

开始日期2023-03-01

申办/合作机构

Max Zeller Söhne AG

[+1]

NCT03482817 / Unknown status临床1期

Drug Cocktail Interaction Study to Investigate the Effect of St. John's Wort Dry Extract Ze 117 on Several Cytochrome P450 Enzymes and on Transporter P-Glycoprotein in Healthy Volunteers

This Study evaluates the Effect of St. John's Wort dry Extract Ze 117 on Several Cytochrome P450 Enzymes and on Transporter P-Glycoprotein in Healthy Volunteers.

开始日期2018-02-05

申办/合作机构

Max Zeller Söhne AG

NCT02505191 / Completed临床1期

A Pilot Phase I, Randomised, Open Mono-center, Multiple Dose, Two Parallel Groups Clinical Trial Investigating the Pharmacokinetics of a Prolonged-release Formulation in Comparison to an Immediate-release Formulation of St. John's Wort Extract Ze 117 in Healthy Male Volunteers Under Fasting Condition

A pilot phase I, randomised, open mono-center, two parallel group clinical trial investigating the pharmacokinetics of a prolonged-release formulation in comparison to an immediate-release formulation of St. John's wort extract Ze 117 in healthy male volunteers under fasting condition.

开始日期2015-11-01

申办/合作机构

Max Zeller Söhne AG

100 项与 Max Zeller Söhne AG 相关的临床结果

登录后查看更多信息

0 项与 Max Zeller Söhne AG 相关的专利（医药）

登录后查看更多信息

52

项与 Max Zeller Söhne AG 相关的文献（医药）

2024-04-01·Phytochemical Analysis

Photostability of sennosides and their aglycones in solution

Article

作者: Meier, Beat ; Wolfram, Evelyn ; Schenk, Alexander ; Meier, Nadja ; Ziegler, Le Nhung ; Peter, Samuel

AbstractIntroductionSennosides are the main active constituents of the dried leaves and/or pods of Senna alexandrina Mill. that are used as laxatives. A hypothesis is that aglycones are formed during the degradation of sennosides. However, it is unknown, whether this happens under visible light exposure and how photosensitive sennosides behave in solution.ObjectivesPure anthraquinone glycosides were tested on their behaviour during sample preparation in the lab under visible light exposure in dependence on the instability of the solvent.Materials and methodsSamples before and after exposure were analysed using UHPLC with UV/Vis and MS detection.ResultsUnder visible light protection, the solutions were stable for 14 days at room temperature whereas a loss of 20%–60% was measured after 1 day of light exposure. The loss of sennosides due to degradation can be as fast as up to 2%–2.5% per hour, which might have a tremendous impact on phytochemical analysis results during the course of an analysis. The formation of aglycones was not observed in the degradation of sennosides and rhein‐8‐O‐glucoside.ConclusionAglycones could not be found as a result of the forced degradation. The solutions of sennosides clearly need to be protected from light to obtain reliable analytical results, and light protection is a major point for the stability of liquid preparations.

2023-04-07·Molecular medicine (Cambridge, Mass.)

Impact of St. John's wort extract Ze 117 on stress induced changes in the lipidome of PBMC.

Article

作者: Bremer, Swen ; Butterweck, Veronika ; Bussmann, Hendrik ; Franken, Sebastian ; Boonen, Georg ; Drewe, Jurgen ; Haberlein, Hanns

BACKGROUNDMembrane lipids have an important function in the brain as they not only provide a physical barrier segregating the inner and outer cellular environments, but are also involved in cell signaling. It has been shown that the lipid composition effects membrane fluidity which affects lateral mobility and activity of membrane-bound receptors.METHODSSince changes in cellular membrane properties are considered to play an important role in the development of depression, the effect of St. John's wort extract Ze 117 on plasma membrane fluidity in peripheral blood mononuclear cells (PBMC) was investigated using fluorescence anisotropy measurements. Changes in fatty acid residues in phospholipids after treatment of cortisol-stressed [1 μM] PBMCs with Ze 117 [10-50 µg/ml] were analyzed by mass spectrometry.RESULTSCortisol increased membrane fluidity significantly by 3%, co-treatment with Ze 117 [50 µg/ml] counteracted this by 4.6%. The increased membrane rigidity by Ze 117 in cortisol-stressed [1 μM] PBMC can be explained by a reduced average number of double bonds and shortened chain length of fatty acid residues in phospholipids, as shown by lipidomics experiments.CONCLUSIONThe increase in membrane rigidity after Ze 117 treatment and therefore the ability to normalize membrane structure points to a new mechanism of antidepressant action of the extract.

2023-01-01·Biomedicine & Pharmacotherapy

Effect of St. John’s wort extract Ze 117 on the lateral mobility of β1-adrenergic receptors in C6 cells

Article

作者: Boonen, Georg ; Franken, Sebastian ; Butterweck, Veronika ; Bussmann, Hendrik ; Häberlein, Hanns ; Drewe, Jürgen

Depression has been associated with altered signal transduction of serotonergic, dopaminergic and adrenergic neurotransmitter systems in the brain. Signaling relies on receptor-ligand interactions and subsequent regulatory processes, but also on lateral receptor mobility. The aim of this study was to investigate the effect of the St. John's wort extract Ze 117 on the lateral mobility of SNAP-tagged β₁-adrenergic receptors (β₁AR) in the plasma membrane of C6 cells under both, non-stimulating and isoprenaline-stimulating conditions. Single particle tracking (SPT) was used, whereby the registered trajectories were evaluated by variational Bayesian treatment of a hidden Markov model (vbSPT) and packing coefficient (Pc) analysis with respect to diffusion coefficients, receptor state occupancies and confinement. Three different diffusion states were identified, differing in their diffusion coefficients. Treatment with Ze 117 [25 µg/ml] decreased the mobility of the β₁AR, which was manifested by a relative increase in the slow-diffusing state S1 (0.21-0.30) compared to control and by an increase in receptor confinement (79.4-68.1 nm). After isoprenaline stimulation of control cells, the slow-diffusing state was more pronounced, whereas confinement was not affected. In summary, SPT has been shown to be a powerful method to analyze lateral receptor mobility. Furthermore, the present study identified a correlation between Ze 117 treatment and β₁AR mobility.

100 项与 Max Zeller Söhne AG 相关的药物交易

登录后查看更多信息

100 项与 Max Zeller Söhne AG 相关的转化医学

登录后查看更多信息