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项与 Alkaloid AD Skopje 相关的临床试验

CTIS2023-507428-21-00

/ Not yet recruiting临床1期

- b1-23-CIDg

开始日期-

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Alkaloid AD Skopje

CTIS2024-514447-29-00

/ Not yet recruiting临床1期

- b4-23-TEMt

开始日期2024-12-02

申办/合作机构

Alkaloid AD Skopje

100 项与 Alkaloid AD Skopje 相关的临床结果

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0 项与 Alkaloid AD Skopje 相关的专利（医药）

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5

项与 Alkaloid AD Skopje 相关的文献（医药）

2011-07-01·International Journal of Electrochemical Science

Evaluation of the Antioxidative Activity by Measuring the Rate of the Homogeneous Oxidation Reaction with Ferroceniumdimethanol Cation. Comparative Analysis of Glutathione and Ascorbic Acid

作者: Mirceski, Valentin ; Komorsky-Lovric, Sebojka ; Davceva, Marija

A simple methodol. for estimation of the antioxidative activity by measuring the kinetics of the homogeneous electron transfer reaction between an antioxidant and ferroceniumdimethanol cation (Fc⁺) is proposed.The method is based on the well-known regenerative E_rC' catalytic reaction scheme, where the antioxidant is catalytically oxidized by Fc⁺, which is in situ formed by the reversible oxidation of ferrocenedimethanol at glassy carbon electrode.Comparing the rate of the homogeneous oxidation of different antioxidant with the same oxidant, i.e., Fc⁺, which serves as a referent system, a more consistent comparison of the antioxidative activity can be done than comparing the heterogeneous oxidation reactions at the electrode surface.The applicability of the method is demonstrated in a comparative anal. of glutathione (GSH) and ascorbic acid (AA), the two important and widely abundant low mol. weight antioxidants, by means of cyclic voltammetry (CV), square-wave voltammetry (SWV), and chronoamperometry (CA).At physiol. conditions (pH ∼ 7) the rate of AA oxidation (∼ 10⁴ mol^-1 L s^-1) is two orders of magnitude higher than GSH (∼ 10² mol^-1 L s^-1) implying superior antioxidative activity of the former.From a methodol. point of view it is important to stress that the kinetic data estimated with CV and CA are comparable, while SWV gives much higher estimates for the catalytic rate constantsThis implies that different techniques lead to different kinetic data, which must be taken into account in estimating the antioxidative activity, as well as in comparing the kinetic data reported in the literature.

Macedonian Journal of Chemistry and Chemical Engineering

Development of a stability-indicating method for evaluation of impurity profile of Atorvastatin film-coated tablets using cyano column based on core-shell technology

作者: Ugarkovic, Sonja ; Kovachovska, Elena Trajchova ; Brezovska, Katerina ; Trajkovic, Stefan ; Acevska, Jelena ; Mitrevska, Ivana ; Dimitrovska, Aneta

This research highlights the specificity of the new stability-indicating method developed to evaluate the impurity profile of Atorvastatin film-coated tablets. The proposed method has the ability to capture any possible changes that may occur during the stability studies over time and under different stress factors, and is selective enough to enable quality control of finished product from different suppliers of active pharmaceutical ingredient (API)/excipients. Satisfactory critical peak resolution between specified and unspecified impurities was achieved using the fused-core shell technology and extensively endcapped diisopropyl-cyanopropylsilane stationary phase (Halo ES-CN 150 mm × 4.6 mm, 2.7 µm), with a 10 mM ammonium formate buffer pH 3.5 and acetonitrile as mobile phase. A potential worse case impurity profile was assumed by using retained samples combined with the data obtained for samples manufactured with APIs from different suppliers exposed to the forced degradation study. The mass balance for stressed samples demonstrated the stability-indicating capability of the proposed method.

Macedonian Journal of Chemistry and Chemical Engineering

Green RP-HPLC for diazepam determination

作者: Nakov, Natalija ; Bozinovska, Marijana ; Tomic, Marija ; Anevska-Stojanovska, Natasa ; Anastasova, Liljana ; Lazova, Jelena ; Petkovska, Rumenka

A new eco-friendly RP-HPLC method for determining diazepam in coated tablets was developed and validated. The separation was achieved on a Lichrosper® 100 RP-18 (250 mm × 4 mm, 5 µm particle size) using the isocratic elution mode with a mobile phase composed of a mixture of water (H2O) and ethanol (EtOH) in a 40:60 (v/v %) ratio and a flow rate of 1.0 mL/min. The injection volume was 10 μL, and the detection wavelength was set at 254 nm. The column temperature was maintained at 35 ºC. The method was validated according to the ICH guideline, emphasizing selectivity/specificity, linearity, sensitivity, accuracy, precision, and robustness. The analytical method greenness score and Eco-scale approach were used for the method’s greenness assessment. The method was applied to determine the assay of diazepam in coated tablets and the uniformity of dosage units by content uniformity. Applying the method proposed in this study in the pharmaceutical industry is considered environmentally sustainable. It would bring benefits in terms of a safer working environment and reduction of toxic waste formation without compromising the reliability of the analytical results.

100 项与 Alkaloid AD Skopje 相关的药物交易

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100 项与 Alkaloid AD Skopje 相关的转化医学

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