BUGWORKS Research, Inc.

BANGALORE, India and SARATOGA, Calif. and ADELAIDE, Australia, Dec. 7, 2023 /PRNewswire/ -- Bugworks Research Inc., a clinical-stage biopharmaceutical company, is presenting the research findings on its novel, best-in-class, dual-acting adenosine antagonists BWC2094 and BWC2562 with the potential to treat a variety of hard-to-treat cancers, at the European Society for Medical Oncology (ESMO) Immuno-Oncology Congress 2023 in Geneva, Switzerland on 7th December. The poster highlights two lead molecules discovered from structure and property-guided drug discovery platform. The molecules demonstrate potent A2A/A2B dual antagonism across a variety of pathologically relevant models that recapitulate the high adenosine driven immunosuppression found in the tumour microenvironment (TME) across several cancers. To build differentiation and improve clinical translation, AI/ML driven virtual trials were employed to identify potential combination drugs, and to guide in patient selection during clinical development. BWC2094 and BWC2562 demonstrate synergistic activity in combination with approved cancer drugs in human peripheral blood assays and proprietary patient-derived ex vivo tumor explant platform as measured by a reduction in the tumor density and increased apoptosis/necrosis. Additionally, these molecules demonstrate good oral bioavailability in rodents and dogs and were found to be well tolerated for 14 days in dose-range finding toxicological studies in preclinical species. Based on the totality of evidence, BWC2094 is ready for IND submission. Bugworks Research is at the forefront of developing novel small molecule drugs to combat hard-to-treat cancers and drug-resistant bacterial infections. The company is building a deep pipeline of differentiated oncology programs that target critical pathways involved in cancer progression and treatment evasion. The ESMO Immuno-Oncology Congress is an annual event offering a forum to present the latest scientific and clinical developments in immunotherapy to diverse stakeholders with an interest to deliver innovative treatments for cancer. Attendees are invited to visit the Bugworks poster on December 7th, 2023, between 12.00-1.00 CET. About Bugworks Bugworks Research Inc. (Bugworks) is a clinical stage biopharmaceutical company, that is developing novel multi-target therapeutic assets in the anti-infective and oncology areas by integrating the latest innovations in computational biology, pharmacology, structural-biology, and medicinal chemistry. For further information, please visit Logo: SOURCE Bugworks

BANGALORE, India and DELAWARE CITY, Del. and ADELAIDE, Australia, April 17, 2023 /PRNewswire/ -- Bugworks Research Inc., a clinical-stage biopharmaceutical company, is set to present its latest research findings on the novel bacterial topoisomerase inhibitor, BWC0977 at the upcoming 33rd European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark. The eight posters highlight data from the microbiological and efficacy studies of the clinical candidate, BWC0977 that exhibits broad-spectrum activity against a globally, diverse panel of Gram-positive, Gram-negative and biothreat pathogens. Additionally, data from a range of studies, including in vitro biochemical assays, in vitro resistance frequency studies, minimum inhibitory concentration (MIC90) data against multi-drug resistant clinical isolates from around the world, and in vivo efficacy data in mice and rat models of infection will be presented. These studies were conducted in collaboration with scientists at the Walter Reed Army Institute of Research (WRAIR), Bethesda, USA, University of Liverpool, United Kingdom, University of Texas Medical Branch, USA, International Health Management Associates (IHMA), USA and TheraIndx Lifesciences Pvt. Ltd., India. "ECCMID 2023 is a globally renowned platform in Infectious Diseases R&D arena, and we are proud to have the opportunity to showcase the pre-clinical highlights of our drug candidate BWC0977; a first-of-its-kind in over six decades that has the potential to treat an entire gamut of infections caused by hard-to-treat Gram-negative and Gram-positive bacterial pathogens," says Dr. Vasanthi Ramachandran, Vice President - Collaborations, Bugworks Research India. Bugworks Research is at the forefront of developing novel antibiotics to combat the growing threat of antimicrobial resistance. The company's cutting-edge research is focused on discovering and developing small molecule drugs that target bacterial enzymes essential for their survival. The ECCMID conference is a leading global forum for infectious diseases and clinical microbiology. Bugworks Research's presentations will take place on April 17th, 2023, during the poster session. Attendees are invited to visit the Bugworks Research booth to learn more about the company's innovative approach to fighting antibiotic resistance. About Bugworks Bugworks Research Inc, (Bugworks), is a clinical stage biopharmaceutical company, that is developing novel multi target therapeutic assets in the anti-infectives and immuno-oncology (IO) areas by integrating the latest innovations in computational biology, pharmacology, structural-biology, and medicinal chemistry. BWC0977 is currently in a Phase 1 clinical trial and is targeted to address unmet needs of serious hospital & community infections, and bacterial biothreats. Its asset for IO is in the late pre-clinical stage, targets multiple cancers and is expected to be used either as standalone or in combination with immune checkpoint therapies. For further information, please visit Media Contact Information Concept Public Relations Archana Jain ([email protected] / +91 98455 41244) Aditi Nair ([email protected] / +91 9071949810) Logo: SOURCE Bugworks

Bugworks - a US, India and Australia based start-up with globally recognized expertise in drug discovery, has set up a dedicated Immuno-oncology ex vivo research lab at the Bengaluru-based hospital, Cytecare. The lab bridges the translation from discovery to development, addressing several hard-to-treat cancers such as gastric, colorectal, renal cell, breast, head and neck, non-small cell lung cancers. This partnership between leading drug discovery start-up and leading cancer hospital paves way for the development of novel Immuno-oncology drugs that can be effective in wider patient populations. The outcome of this translational research will guide the first-in-human trials, expected to commence in early 2024. BENGALURU, India, Sept. 19, 2022 /PRNewswire/ -- Bugworks Research Inc., a clinical stage biopharmaceutical company, and Cytecare Cancer Hospitals today announced the launch of a first-of-its-kind collaboration. Bugworks develops best-in-class, novel therapies for cancer and infectious diseases & has set up a dedicated research center within Cytecare, which is committed to excellence in treating cancer patients. Continue Reading Cytecare Logo The coming together of a leading innovator in drug discovery and a state-of-the-art cancer hospital promises to be a game changer in saving countless human lives. Bugworks' drug discovery engine coupled with Cytecare's excellence in delivering optimal clinical outcomes will offer differentiated solutions to patients all over the world. Commenting on the significance of this strategic collaboration, Suresh Ramu, Co-Founder & CEO, Cytecare Cancer Hospitals, said, "We are excited to partner with Bugworks Research, in this inspiring endeavor to discover novel treatments for different types of cancers. In 2016, we started with the vision of building the country's best institution for cancer care, supported by India-specific research data. At Cytecare, we are committed to provide the best possible treatment to patients and support cutting-edge research. We strongly believe that affordable and accessible immuno-oncology therapies can come from India and be made accessible to all patients. This collaboration heralds a brave new beginning to a healthier future." Bugworks' current research in immuno-oncology centers around modulating the tumour microenvironment that includes adenosine antagonism - an area of research with applications across many solid tumours. The drug candidates from this research will undergo translational testing on patient-derived tumours in the ex vivo laboratories at Cytecare, prior to progressing to first-in-human clinical studies. Dr. V. Balasubramanian, Co-Founder and COO, Bugworks, noted, "We are discovering highly differentiated, novel small molecule immunotherapeutic agents that target the immunosuppressive and tumour-promoting microenvironment. The ex vivo laboratories at Cytecare Cancer Hospitals, as part of our collaboration, will greatly aid the translation of our research to high percentage successful clinical outcomes." At present, immunotherapy is an important pillar in the armamentarium of cancer care. The currently approved agents are indeed life-saving, albeit only for a small segment of patients. Bugworks' approach, in collaboration with Cytecare Hospitals, offers new avenues to increase the percentage of patients who would benefit from these life-saving immunotherapies. The current collaboration is a small, yet significant step in helping India become a biotech powerhouse. About Bugworks Research () Bugworks Research is a clinical-stage biopharmaceutical company, developing novel therapeutic assets to combat Antimicrobial Resistance (AMR) and immunotherapies to treat cancer patients using innovative structure-guided medicinal chemistry. Its AMR asset, BWC0977, currently in Phase 1 human studies will address serious hospital, community and biothreat bacterial infections. Its immuno-oncology pipeline is in pre-clinical development and has the potential to target multiple cancers. About Cytecare Cancer Hospitals () Cytecare launched its flagship center, Cytecare Cancer Hospitals, a 150-bed organ-site focused cancer hospital, in November 2016 at Yelahanka, Bengaluru. Founded on the principle of 'Fighting Cancer the Right Way', Cytecare houses some of the finest surgeons, physicians, medical oncologists, radiation oncologists, and other clinical experts in the country within its world-class facility. Patient-centricity is a hallmark of treatment at Cytecare and today their comprehensive clinical team delivers holistic healing across a range of medical specialties. Cytecare is also a part of multiple global clinical research studies, which ensures continuous learning & improvement in clinical outcomes for their patients. Cytecare delivers a consistently high-level of specialized care for thousands of cancer patients, from more than 40 countries. For enquiries contact: Pradeep Fernandes [email protected] Logo: Logo: SOURCE Bugworks