Delving into the Latest Updates on Pontifícia Universidade Católica do Rio de Janeiro with Synapse

概览

疾病领域	数量

感染	1

排名前五的药物类型	数量

预防性疫苗	1

排名前五的靶点	数量

SARS-CoV-2 3CLpro x SARS-CoV-2 E protein x SARS-CoV-2 N protein x SARS-CoV-2 S protein	1

关联

1

项与 Pontifícia Universidade Católica do Rio de Janeiro 相关的药物

Multiepitope vaccines(Pontifical Catholic University of Rio de Janeiro)

靶点

SARS-CoV-2 3CLpro x SARS-CoV-2 E protein x SARS-CoV-2 N protein x SARS-CoV-2 S protein

作用机制

SARS-CoV-2 3CLpro 抑制剂 [+3]

在研机构

Pontifícia Universidade Católica do Rio de Janeiro

原研机构

Pontifícia Universidade Católica do Rio de Janeiro

在研适应症

冠状病毒感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

2

项与 Pontifícia Universidade Católica do Rio de Janeiro 相关的临床试验

RBR-3r6pc2

/ RecruitingN/A

Cognitive stimulation therapy for Dementia: Brazilian adaptation and validation

开始日期2017-07-01

申办/合作机构

Pontifícia Universidade Católica do Rio de Janeiro

[+1]

NCT02671578

/ Completed临床4期IIT

Bispectral Index and Clinical Parameters Evaluation in Different Dental Procedures With Nitrous Oxide and Oxygen Sedation

BACKGROUND: The degree of consciousness during nitrous oxide use is still a matter of concern for both dentists and anesthesiologists. Investigators hypothesized that BIS levels do not vary according nitrous oxide concentration during minimum to moderate sedation in the dental treatment.
METHODS: One hundred patients undergoing dental procedures demanding local anesthesia (1.8 mL of 2% lidocaine with 1:100.000 epinephrine) were enrolled in this study. Initial pain and anxiety were measured by 11-point numerical and anxiety visual scales, respectively. Systolic/diastolic arterial blood pressure, SpO2, heart and respiratory rates, and psychomotor ability (Trieger test) were assessed before, during and after dental treatment. Sedation levels were evaluated by both BIS and sedation analogic scale at the same intervals. The duration of treatment along with nitrous oxide concentration and side effects were observed. Kruskal-Wallis, Friedman and Mann-Whitney tests were used (alpha=5%).

开始日期2006-11-01

申办/合作机构

University of Campinas

[+1]

100 项与 Pontifícia Universidade Católica do Rio de Janeiro 相关的临床结果

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0 项与 Pontifícia Universidade Católica do Rio de Janeiro 相关的专利（医药）

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17,613

项与 Pontifícia Universidade Católica do Rio de Janeiro 相关的文献（医药）

2025-08-01·Journal of Pharmaceutical and Biomedical Analysis

N-doped graphene quantum dots combined with Ag nanoparticles for luminescence based analytical sensing of gentamycin after solid-phase extraction in a molecularly-imprinted polymer

Article

作者: da Silva, Andrea R ; De Falco, Anna ; Almeida, Joseany M S ; Pinto, Igor A ; Pedrozo-Peñafiel, Marlin J ; Toloza, Carlos A T ; Larrude, Dunieskys G ; Aucelio, Ricardo Q

A luminescence-based method was developed to detect gentamicin using silver nanoparticles (AgNPs) associated with nitrogen-doped graphene quantum dots (N-GQDs). When gentamicin sulfate interacts with the AgNPs/N-GQDs system, the characteristic blue fluorescence of N-GQDs, which had been previously turned off by AgNPs, is restored. Under specific conditions (such as the amount of synthesis dispersion and pH), this AgNPs/N-GQDs probe enabled quantification of gentamicin ranging from 3.0 × 10^-7 to 6.0 × 10^-6 mol L^-1. To address interference from other substances during the analysis, a solid-phase extraction, with a kanamycin-imprinted polymer cartridge, enabled accurate results. Two veterinary pharmaceutical samples were used to test the method and results were in agreement with those achieved by obtained using high-performance liquid chromatography with analyte chemical derivatization. This new method is straightforward, sensitive, and selective, and it is also considered eco-friendly (0.63 score Analytical greenness calculator) since it avoids the use of toxic chemical derivatization reagents, use nanoquantities of carbon and silver based nanomaterials and aqueous systems.

2025-05-01·Optical Materials Express

Nanocellulose-based materials for photonic applications [Invited]

作者: Pugina, R. S. ; Ribeiro, S. J. L. ; Cremona, M. ; Legnani, C. ; Torres, F. R. ; Fontes, M. L. ; Barud, H. S. ; Santos, M. V. ; Onishi, B. S. D.

The escalating demand for optical and photonic devices across various sectors, encompassing energy, sustainability, medicine, information and communication technologies, is catalyzing the pursuit of renewable and eco-friendly materials. From the perspective of materials science, nature polymers emerge as a versatile resource for designing optical and photonics devices, offering unique opportunities for integrating technology sustainability. Among natural polymers, nanocellulose (NC) stands out, presenting boundless opportunities for processing, functionalization, and biological integration. Interest in the direct use and strategic re-engineering of NC as a platform for developing advanced optical and photonic materials has significantly increased over the past decade. This review consolidates recent advancements in the processing of NC-based materials for active photonic devices. Furthermore, it addresses the challenges and delineates directions for further device design and fabrication. We foresee NC playing a pivotal role in facilitating the future exploitation of sustainable, intelligent, implantable, wearable, and multifunctional optical devices.

2025-05-01·GCB Bioenergy

Incorporating Biochar Into Biogeochemical Models: Achievements and Challenges

作者: Latawiec, Agnieszka Ewa ; Ronix, Amanda ; Carvalho, João Luís Nunes ; da Silva Neto, Eduardo Carvalho ; Cerri, Carlos Eduardo Pellegrino

ABSTRACTIn the last two decades, several studies have utilized biogeochemical models to evaluate the impact of different edaphoclimatic conditions on soil carbon storage and the dynamics of soil organic carbon. At the same time, biochar, a carbon‐rich material obtained from the pyrolysis of biomass residues, has been identified as a promising carbon sequestration material. However, current models do not adequately incorporate the role of biochar in soil management. In this context, the current state of research on biogeochemical models that include the entry of biochar into soil has been characterized. The research indicated that the development of studies on the topic “biochar” is widely explored, with 4259 papers being identified using the first search filter. Specifically, searching for studies that mentioned terms related to biogeochemical models for estimating soil carbon stock, it was observed that a small number of the studies (N = 46) considered the entry of biochar into the models. Although most studies have used the RothC model to simulate biochar within biogeochemical models, biochar inputs have also been implemented in APSIM, EPIC, Century, DNDC, and other models, including those not primarily focused on soil carbon stock estimation. Among these studies, the minority included the results of calibration and validation of the models, which are paramount for the model's credibility. Therefore, efforts must be concentrated on solving the lack of valuable data to validate the models. Data from long‐term field experiments that consider interactions between crop and climate conditions are highly desirable. The possibility of increasing carbon stocks by incorporating biochar into the soil could promote environmental and financial gains, and biogeochemical models that consider the incorporation of biochar are valuable tools for decision‐makers.

100 项与 Pontifícia Universidade Católica do Rio de Janeiro 相关的药物交易

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100 项与 Pontifícia Universidade Católica do Rio de Janeiro 相关的转化医学

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当前项目

药物(靶点)	适应症	全球最高研发状态

Multiepitope vaccines(Pontifical Catholic University of Rio de Janeiro) ( SARS-CoV-2 3CLpro x SARS-CoV-2 E protein x SARS-CoV-2 N protein x SARS-CoV-2 S protein )	冠状病毒感染更多	临床前