A 16 week exploratory, Proof of Concept study to evaluate the effect of Fostamatinib (12 weeks of treatment) upon cutaneous inflammation in Hidradenitis Suppurativa.

开始日期2021-10-01

申办/合作机构

Holdsworth House Medical Practice

[+1]

NCT04161014 / Recruiting临床2期

The Nintedanib in Progressive Pneumoconiosis Study (NiPPS): a Collaborative NSW Treatment Trial

Prospective clinical pilot study for subjects diagnosed with Occupational Progressive Pneumoconiosis.
Subjects will be treated with Nintedanib 150mg twice daily for 3 years.

开始日期2020-10-09

申办/合作机构

Holdsworth House Medical Practice

[+1]

NCT04354818 / Unknown statusN/AIIT

Coronavirus Outcomes Registries in Immunocompromised Individuals Australia (CORIA): a Multisite Registry and Optional Biorepository in People With COVID-19 and Selected Conditions Affecting Immune Function

CORIA is an observational cohort study of immunosuppressed populations who test positive for COVID-19. This includes people living with HIV, cancer, acquired immunodeficiency associated with other immunosuppressive therapy, primary immunodeficiency and recipients of a solid organ transplant. Participants will have routine clinical data collected with optional baseline collection and storage of a blood sample for storage . The study will be conducted in up to 30 sites within Australia.

开始日期2020-05-11

申办/合作机构

Kirby Institute

[+12]

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项与 Holdsworth House Medical Practice 相关的文献（医药）

2024-10-01·International Journal of Transgender Health

“Ever since I knew I was trans I knew I wanted hormone therapy”: a qualitative exploration into the journey of Australian trans individuals accessing feminizing gender-affirming hormone therapy

Article

作者: Warzywoda, Sarah ; Dean, Judith A. ; Wood, Penny ; Franks, Nia ; Bisshop, Fiona ; Fowler, James A.

BackgroundFor many trans folks, gender-affirming hormone therapy (GAHT) is a desired affirming procedure that has been linked with positive health outcomes, however literature has had little focus on the journeys of trans people as they access GAHT.AimTo understand trans people's journey of accessing GAHT to delineate supports necessary to better engage trans individuals into gender-affirming care.MethodThis study conducted semi-structured interviews with a sample of 15 Australian trans adults who participated in a larger study investigating the effects of a cyproterone acetate titration protocol.FindingsA four-factor thematic structure was created from the data. Theme one describes early cognizance of being trans and the pivotal moments in their trans realization. The second theme explores the rapid engagement with community to begin accessing information and affirming healthcare, including GAHT. The third theme explores barriers to engaging in GAHT and theme four reflects on advice participants have for other trans people who are considering GAHT.ConclusionFindings from this study emphasize the importance of providing support to young trans people to help reconcile their gender identity and assist them to engage into care as early as possible. It also highlights the key role that community plays in providing links to affirming information and providers of GAHT - but also emphasizes the importance of considering how to engage with community who may be missed. The experience of accessing GAHT is personal and contextual, but signaling of affirming safe spaces and access to salient information may be key strategies to better support trans people choosing to access GAHT.

2024-06-04·Proceedings of the National Academy of Sciences

Tissue comparability and bias in hidradenitis suppurativa transcriptomic studies

Article

作者: Frew, John W ; Nebo, Ikenna David ; Gudjonsson, Johann E ; Petukhova, Lynn

2024-03-28·Open Forum Infectious Diseases

Risk of Primary Incident Hepatitis C Infection Following Bacterial Sexually Transmissible Infections Among Gay and Bisexual Men in Australia From 2016 to 2020

Article

作者: Bloch, Mark ; Matthews, Gail V ; Agius, Paul ; Harney, Brendan L ; Hellard, Margaret E ; Donovan, Basil ; Fairley, Christopher K ; Guy, Rebecca ; Doyle, Joseph S ; van Santen, Daniela K ; Sacks-Davis, Rachel ; Roth, Norman ; Wilkinson, Anna L ; Asselin, Jason ; Stoové, Mark ; Traeger, Michael W

AbstractBackgroundIn Australia, the incidence of hepatitis C virus (HCV) has declined among gay and bisexual men (GBM) with human immunodeficiency virus (HIV) since 2015 and is low among GBM using HIV preexposure prophylaxis (PrEP). However, ongoing HCV testing and treatment remains necessary to sustain this. To assess the potential utility of sexually transmissible infections (STIs) to inform HCV testing among GBM with HIV and GBM using PrEP, we examined the association between bacterial STI diagnoses and subsequent primary HCV infection.MethodsData were from a national network of 46 clinics participating in the Australian Collaboration for Coordinated Enhanced Sentinel Surveillance. GBM included had ≥1 HCV antibody negative test result and ≥1 subsequent HCV antibody and/or RNA test. Discrete time survival analysis was used to estimate the association between a positive syphilis, rectal chlamydia, and rectal gonorrhea diagnosis in the previous 2 years and a primary HCV diagnosis, defined as a positive HCV antibody or RNA test result.ResultsAmong 6529 GBM with HIV, 92 (1.4%) had an incident HCV infection. A prior positive syphilis diagnosis was associated with an incident HCV diagnosis (adjusted hazard ratio, 1.99 [95% confidence interval, 1.11–3.58]). Among 13 061 GBM prescribed PrEP, 48 (0.4%) had an incident HCV diagnosis. Prior rectal chlamydia (adjusted hazard ratio, 2.75 [95% confidence interval, 1.42–5.32]) and rectal gonorrhea (2.54 [1.28–5.05]) diagnoses were associated with incident HCV.ConclusionsDiagnoses of bacterial STIs in the past 2 years was associated with HCV incidence. These findings suggest that STIs might be useful for informing HCV testing decisions and guidelines for GBM with HIV and GBM using PrEP.

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