COMPARATIVE ANALYSIS ON THE EFFECTIVENESS OF MUSCLE ENERGY TECHNIQUE AND MAITLAND MOBILIZATIONS IN THE MANAGEMENT OF CHRONIC SACRO ILIAC JOINT DYSFUNCTION FOR IMPROVING PAIN AND DISABILITY: A RANDOMIZED CONTROL TRIAL

开始日期2635-09-06

申办/合作机构

Khyber Medical University

NCT05305352 / WithdrawnN/AIIT

Very Low Carbohydrate Dietary Intervention in Gestational Diabetes Mellitus: Effect on Glycemic, Metabolic, Glycated and Inflammatory Marker: A Randomized Controlled Trial

Uncontrolled Gestational Diabetes Mellitus may leads to maternal and fetal complications. These complications can be avoided by adopting the dietary modifications along with medications. Previous studies suggested that consumption of low Carbohydrate diet improves Gestational Diabetes and related complications. Therefore, this study aims to investigate the effect of very low carbohydrate dietary intervention on glycemic, glycemic, metabolic, glycated and inflammatory markers.

开始日期2025-01-01

申办/合作机构

Khyber Medical University

NCT06561126 / RecruitingN/AIIT

Engagement of coMmunity Through Participatory Learning and Action for cOntrol and preVEntion of Type II Diabetes and Its Risk Factors [EMPOWER-D]: Cluster Randomized Controlled Trial

This project aims to adapt, implement, and evaluate Participatory Learning and Action (PLA) based intervention in rural areas of KPK, Pakistan which includes Peshawar and Swabi for TIIDM prevention and control. The pivotal components of this approach include adapting, implementing, and evaluating the PLA-based intervention for the prevention and control of Type II diabetes. These components will be tailored to meet the specific needs of two different settings in Peshawar and Swabi, Pakistan.
Type II Diabetes Mellitus (TIIDM) is considered the fastest-growing health emergency, affecting 537 million adults worldwide. Global projections for the year 2045 suggest that a 12.2% rise in TIIDM is anticipated with an additional 11.4% rise for intermediate hyperglycemia (IHG) [1]. Around 80% of people with TIIDM reside in low-and middle-income countries (LMICs), exhausting the already burdened healthcare system [2]. The intervention "Community groups or mobile phone messaging to prevent and control type 2 diabetes and intermediate hyperglycemia in Bangladesh (DMagic)" has been tested and found effective in the rural context of Bangladesh [1-3]. A full trial will be conducted in the rural areas of Peshawar and Swabi, Pakistan.
It is anticipated that with the use of evidence-based approaches, best practices, and meaningful community participation, PLA is expected to enhance social and behavioural determinants of health and subsequent outcomes. This will further pave the way for the control of other NCDs through a similar focused approach.

开始日期2024-09-01

申办/合作机构

Khyber Medical University

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项与 Khyber Medical University 相关的文献（医药）

2024-12-31·European Journal of Materials

Assessment of chlorohexidine-coated cotton filler addition on resin-based fissure sealants’ mechanical, water sorption, and antibacterial properties

作者: Liaqat, Saad ; Gul, Sajida ; Muhammad, Nawshad ; Khan, Muhammad Adnan ; Ahmad, Naveed

The occlusal surfaces of posterior teeth are susceptible to caries formation due to the presence of pits and fissures.The bacteria present in the oral cavity and food particles are accumulated on these complex structures.To prevent and protect the tooth structure, different additives were added to pits and fissures sealants to improve adhesion with tooth structure, enhance the mech. properties, and prevent bacterial growth.In this regard, cotton was coated with chlorohexidine (CHX) and incorporated in a resin-based sealant to improve its mech. properties (compressive and flexural strength), mass change, and bacterial properties.The mean compressive strength values of CHX coated cotton modified RBS samples S1, S2 & S3 were significantly higher than the control group.The mean flexural strength value of group S1 was significantly higher as compared to the C, S2 & S3.Disc diffusion methods showed a significantly higher value of (p-value = 0.003) antibacterial potential of groups S2 and S3 as compared to group C.The mean percent mass change values of S1, S2 & S3 were higher than the control group.Hence the addition of CHX-coated cotton fillers in RBS improved its properties.

2024-12-01·Molecular Biology Reports

The association of ABCB1 gene polymorphism with clinical response to carbamazepine monotherapy in patients with epilepsy

Article

作者: Khattak, Muhammad Ijaz Khan ; Ullah, Shakir ; Carr, Daniel F ; Asad, Muhammad Imran ; Rehman, Mujeeb Ur ; Rashid, Haroon Ur ; Tipu, Muhammad Khalid

BACKGROUNDEpilepsy is a common neurological disease but around 30% of patients fail to respond to antiepileptic drug (AED) treatment. Genetic variation of the ATP-binding cassette subfamily B, member 1 (ABCB1) gene, a drug efflux transporter may infer treatment resistance by decreasing gastrointestinal absorption and preventing AED entry into the brain. This study examined the impact of ABCB1 genetic variants on carbamazepine responsiveness.MATERIALS AND METHODSGenomic DNA was extracted from whole blood of 104 epileptic patients. Genotyping of 3 ABCB1 variants (c.C3435T, c.G2677T/A and c.C1236T) was undertaken using validated TaqMan allelic discrimination assays. Plasma carbamazepine levels were measured at 3 and 6 months following the initial dose using high-performance liquid chromatography (HPLC) alongside clinical outcomes evaluation.RESULTSNonresponse to carbamazepine (CBZ) was associated significantly with the ABCB1 variants c.C3435T, c.G2677T/A, c.C1236T and TTT, TTC haplotypes (P < 0.05). There was no significant association between variants and plasma CBZ level (P > 0.05).CONCLUSIONSOur results showed that variant alleles of the ABCB1 gene and TTT, TTC haplotypes were significantly associated with CBZ resistance without affecting the plasma level of carbamazepine. The findings of this study may help to predict patient's response to treatment ultimately it will improve the personalized and evidence based treatment choice of patients with epilepsy.

2024-12-01·Annals of Diagnostic Pathology

Ovarian angiosarcoma: A systematic review of literature and survival analysis

Review

作者: Gutierrez, Jesus ; Silwal, Amisha ; Harikrishna, Arya ; Sumie, B R ; Maddi, Meghana ; Rehman, Shafi ; Huynh, Linh ; Farrukh, Ameer Mustafa ; Kolhe, Nisha ; Annepu, Yoshita Rao ; Mohamed, Safdar

Ovarian angiosarcoma (OA) is rare, with only sporadic cases reported in English literature. We performed a systematic review of cases published in the PubMed, Science Direct, and Google Scholar databases with the aim of describing the reported clinicopathological features of OA. Fifty-three articles that reported 60 patients were reviewed. Of the 60 patients, 7 (11.6 %) were diagnosed with secondary (metastatic) ovarian angiosarcoma and 53 (88.3 %) were diagnosed with primary ovarian angiosarcoma. The mean age at presentation for ovarian angiosarcoma was 38.3±17.8 years. The average tumor size for ovarian angiosarcoma was 11.9±6.1 cm. Abdominal distention was reported in 45/60 (75 %). Microscopic examination revealed necrosis in 28/60 (46.7 %), pleomorphism in 32/59 (54.2 %), mitotic figures in 44/60 (73.3 %), spindle-shaped cells in 27/36 (75 %), epithelioid-shaped cells in 20/36 (55.5 %), and mixed epithelioid and spindle-shaped cells in 12/36 (33.3 %) patients. On immunohistochemistry CD 31 was positive in 41/41 (100 %), CD 34 in 38/39 (97.4 %), and Factor VIII related antigen in 18/21 (85.7 %) patients. Metastasis was present in 43/60 (71.6 %) patients. Chemotherapy and surgery was performed in 36/52 (69.2 %). The median follow-up time for ovarian angiosarcoma was 7 months (IQR1-IQR3:2-13.5 months). 24 (48 %) of the 50 patients with available survival data were alive and 26/50 (52 %) were dead of disease. Survival analyses (KM curves) revealed that the presence of necrosis (log-rank test; p = 0.05) and absence of spindle-shaped cells (log rank test; p = 0.04) on histopathology were associated with worse outcomes, while treatment with combined chemotherapy and surgical excision was associated with better survival (P < 0.001) therefore, prompt diagnosis and early treatment with combined chemotherapy and surgical excision can prolong survival in OA.

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