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项与 Kanebo Ltd. 相关的药物

GSC-150

靶点

E-sel x L-sel x P-sel

作用机制

E-sel抑制剂 [+2]

在研机构-

原研机构

Kanebo Ltd.

在研适应症-

非在研适应症

炎症

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

KB-R5608

靶点

Kv7.2

作用机制

Kv7.2激动剂

在研机构-

原研机构

Kanebo Ltd.

在研适应症-

非在研适应症

高血压

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Kanebo Ltd. 相关的临床结果

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0 项与 Kanebo Ltd. 相关的专利（医药）

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628

项与 Kanebo Ltd. 相关的文献（医药）

2011-04-12·Journal of Pharmacy and Pharmacology3区 · 医学

Effect of KBT-3022, a New Diphenylthiazole Derivative, on Platelet Functions

3区 · 医学

Article

作者: Yamashita, Akira ; Oda, Minoru ; Yokota, Koichi ; Yamamoto, Noriko ; Morimoto, Yasuo

AbstractThe effects of KBT-3022 and its metabolite desethyl KBT-3022 on platelet aggregation were determined in rat, guinea-pig, rabbit and human platelets in-vitro and ex-vivo.KBT-3022 and desethyl KBT-3022 inhibited platelet aggregation induced by arachidonic acid and collagen in-vitro more potently than aggregation induced by adenosine diphosphate, platelet-activating factor or thrombin, as well as by acetylsalicylic acid, and their effects were approximately 100 times more potent than those of acetylsalicylic acid.Desethyl KBT-3022, but not KBT-3022 or acetylsalicylic acid, inhibited thrombin-induced aggregation and 5-hydroxytryptamine release from platelets more potently than ticlopidine hydrochloride at higher concentrations. Oral administration of KBT-3022 inhibited both arachidonic acid- and collagen-induced platelet aggregation and reduced platelet retention in a glass-bead column approx. 100 times more potently than acetylsalicylic acid. KBT-3022 showed little or no anti-inflammatory effect on either ultraviolet-induced erythema or arachidonic acid induced ear oedema, and had lower gastro-ulcerogenicity than acetylsalicylic acid.These results suggest that KBT-3022 is a potent inhibitor of platelet activation with weak side-effects.

2005-02-01·YAKUGAKU ZASSHI4区 · 医学

Antiobesity Actions of <i>Zingiber officinale</i> Roscoe

4区 · 医学

Article

作者: SAITO, Masato ; OKUDA, Hiromichi ; KAWANO, Shiho ; KIMURA, Yoshiyuki ; HAN, Li-Kun ; GONG, Xiao-Jie

Zingiber officinale Roscoe has been used as a folk medicine in China. An aqueous extract of Z. officinale Roscoe inhibited the hydrolysis of triolein emulsified with phosphatidylcholine by pancreatic lipase in vitro and it reduced the elevation of rat plasma triacylglycerol levels 1 and 2 h after oral administration of a lipid emulsion containing corn oil. These results suggest that the aqueous extract of Z. officinale Roscoe might inhibit the intestinal absorption of dietary fat by inhibiting its hydrolysis. Therefore we investigated the antiobesity effects of the aqueous extract of Z. officinale Roscoe by feeding a high-fat diet to mice for 8 weeks. Body weights at 2-8 weeks and final parametrial adipose tissue weights were significantly lower in mice fed the high-fat diet containing 3% aqueous extract of Z. officinale Roscoe than in the controls fed the high-fat diet. Feeding a high-fat diet containing 1% aqueous extract of Z. officinale Roscoe also significantly reduced final parametrial adipose tissue weights that were elevated in mice fed the high-fat diet alone. Our data suggest that the antiobesity effect of aqueous extract of Z. officinale Roscoe in mice fed a high-fat diet may be due in part to the inhibition of intestinal absorption of dietary fat by the active compounds of Z. officinale Roscoe.

2004-01-01·Immunopharmacology and Immunotoxicology4区 · 医学

Effects of Hochu‐ekki‐to and Ninjin‐youei‐to, Traditional Japanese Medicines, on Porcine Serum‐Induced Liver Fibrosis in Rats

4区 · 医学

Article

作者: Nomoto, Kikuo ; Ochi, Takashi ; Kawakita, Takuya

In this study, we estimated the effects of traditional Japanese medicines on liver fibrosis in Wistar rats injected with porcine serum twice a week for 8 weeks. The rats were orally administered Hochu-ekki-to, Ninjin-youei-to (100 and 300 mg/kg/day) or Sho-saiko-to (300 mg/kg/day) 5 days per week. Serum and liver samples were obtained 2 days after the last porcine serum injection. Hochu-ekki-to and Ninjin-youei-to showed significant suppressive effects on the increase in hepatic hydroxyproline, namely total collagen. Further, Ninjin-youei-to significantly suppressed the increases of type IV collagen localized in the basement membrane and prolyl 4-hydroxylase, a collagen synthesis enzyme, in serum or liver. Hochu-ekki-to showed a similar trend. Although Sho-saiko-to did not significantly suppress the increase in hepatic hydroxyproline, it intensely suppressed serum type IV collagen. Further, Hochu-ekki-to, Ninjin-youei-to, and Sho-saiko-to inhibited the production of fibrogenic cytokines, namely TGF-beta1 and IL-13, in the serum and liver. Additionally, we showed that IL-13 levels were positively correlated with hydroxyproline contents in the liver. These results suggest that Ninjin-youei-to as well as Hochu-ekki-to suppress porcine serum-induced liver fibrosis more effectively than Sho-saiko-to. The effects of these three medicines probably depend on the inhibition of fibrogenic cytokine production, resulting in the suppression of collagen synthesis and deposition in the liver, though different mechanisms underlie their anti-fibrogenic effects.

100 项与 Kanebo Ltd. 相关的药物交易

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100 项与 Kanebo Ltd. 相关的转化医学

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