Delving into the Latest Updates on Warsaw Agricultural University with Synapse

概览

疾病领域	数量

内分泌与代谢疾病	2
肿瘤	2
神经系统疾病	1

排名前五的药物类型	数量

蛋白药物偶联	2
巨噬细胞疗法	2

排名前五的靶点	数量

Tubulin(微管蛋白)	1

关联

2

项与 Warsaw Agricultural University 相关的药物

MDC-735

靶点

Tubulin

作用机制

微管蛋白抑制剂

在研机构

Warsaw Agricultural University [+3]

原研机构

Cellis Oy

在研适应症

膀胱癌 [+9]

非在研适应症-

最高研发阶段临床1期

首次获批国家/地区-

首次获批日期-

MDC-250

靶点-

作用机制-

在研机构

Cellis Sp. Z O.O. [+2]

原研机构

Cellis Oy

在研适应症

胰腺癌 [+1]

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Warsaw Agricultural University 相关的临床结果

登录后查看更多信息

0 项与 Warsaw Agricultural University 相关的专利（医药）

登录后查看更多信息

24,858

项与 Warsaw Agricultural University 相关的文献（医药）

2025-07-01·European Journal of Pharmacology

Pharmacokinetics of oxycodone in rats: Influence of micronized magnesium lactate on oxycodone bioavailability

Article

作者: Strus, Bartosz ; Szterk, Arkadiusz ; Hijano, Daniel Ortega ; Ofiara, Karol ; Flis, Sylwia

This article presents studies on the pharmacokinetics of oxycodone hydrochloride and the influence of micronized magnesium lactate on its bioavailability and pharmacokinetic parameters. Two methods, HPLC-DAD, and HPLC-MS/MS, were developed and validated to investigate the content of oxycodone hydrochloride in the developed medicinal products and, oxymorphone in blood serum using an isotopic dilution method. The aim was to develop a novel pharmaceutical formulation combining oxycodone hydrochloride with Mg²⁺, which could increase the efficacy of analgesia while reducing the opioid dose. Experiments were conducted on Wistar rats, analyzing the changes in plasma concentrations of oxycodone hydrochloride and its metabolite oxymorphone after intragastric administration of two formulations: one containing oxycodone hydrochloride alone and the other with the addition of micronized magnesium lactate. The results indicate that the presence of Mg²⁺ decrease the bioavailability of oxycodone, which is related to chemical reactions between the formulation components. This phenomenon has been overlooked by other researchers determining the interaction of Mg²⁺ with opioids in enhancing the antinociceptive effect of opioids.

2025-06-01·The Journal of nutrition, health and aging

Associations between time spent in sedentary behaviors and metabolic syndrome risk in physically active and inactive European older adults

Article

作者: Nilsson, Andreas ; Kaluza, Joanna ; Jurado-Medina, Laura Smeldy ; Jennings, Amy ; Fairweather-Tait, Susan ; Santoro, Aurelia ; Limem, Hadil ; Kadi, Fawzi ; Berendsen, Agnes A M ; Franceschi, Claudio ; de Groot, Lisette C P G M ; Januszko, Olga

OBJECTIVESTo determine how clustered metabolic risk based on a validated continuous metabolic syndrome risk score is associated with objectively assessed time in sedentary behaviors (SB) in physically active and inactive older adults, while considering adherence to healthy eating habits.DESIGNCross-sectional study SETTING AND PARTICIPANTS: The study comprises 871 community-dwelling older adults (age 65-79 years) recruited from four European countries.MEASUREMENTSDaily times spent in SB and physical activity (PA) were assessed by accelerometers (Actigraph GT3X) for a week. Waist circumference, triglycerides, HDL-cholesterol, mean arterial blood pressure, fasting glucose and insulin were determined, and a continuous metabolic syndrome risk score (cMSy) was generated using principal component analysis. Healthy eating habits were assessed by food record. General linear models stratified by adherence to PA guidelines (active/inactive) were used to examine differences in cMSy across tertiles of time in SB (Low, Medium, High) with adjustment for covariates, including healthy eating habits.RESULTSA significantly (p < 0.05) lower cMSy was observed among older adults in the low SB tertile compared to medium and high SB tertiles, with no difference between the latter tertiles. The favorable effect of low amounts of SB on cMSy was indicated in both active and inactive groups, and regardless of healthy eating habits. Further, being active was related to a more favorable cMSy across all SB tertiles.CONCLUSIONLow amounts of time spent in SB are related to a lower metabolic syndrome risk regardless of adherence to PA guidelines and healthy eating habits in older adults, supporting guidelines targeting limited amounts of SB alongside engagement in moderate-to-vigorous PA for promotion of metabolic health.

2025-06-01·Poultry Science

Effects of husbandry practices on Ross 308 and Hubbard chicken hybrids welfare

Article

作者: Jaszczyk, Aneta ; Wójcik, Wojciech ; Adamek-Urbańska, Dobrochna ; Ludwiczak, Agnieszka ; Stelmasiak, Adrian ; Damaziak, Krzysztof ; Spoolder, Hans ; Sell-Kubiak, Ewa ; Barłowska, Katarzyna ; Marchewka, Joanna ; Strzałkowska, Nina ; Pogorzelski, Grzegorz ; Horbańczuk, Jarosław O ; Sztandarski, Patryk ; Michnowska, Hanna ; Kemp, Bas ; Solka, Magdalena

This study evaluated the impact of husbandry practices including enrichments, diet, stocking density, genotype, and outdoor access on welfare indicators in fast-growing Ross 308 and two genotypes of medium-growing Hubbard hybrids of chickens. The set of studies was designed with specific factors relevant to each genotype, with stocking density, perch enrichment and lucerne provision targeted for Ross 308 broilers and perch, outdoor access, as well as genotype (JA757 and JA787) for Hubbard chickens. Feather condition, footpad dermatitis (FPD), comb wounds, skin injuries, hock burn, lameness, dirtiness, toe damage, respiratory infections, and diarrhea were evaluated at the end of each production cycle. For Ross 308, just like for Hubbard hybrids, enrichment with perches significantly deteriorated feather condition (P = 0.03). Lucerne provision enhanced footpad health (P = 0.02) and reduced comb wounds (P = 0.03). For Hubbard hybrids, outdoor access led to a reduction in comb wounds (P = 0.04) and FPD severity (P = 0.02). Additionally, differences in plumage damage were observed between the Hubbard hybrid genotypes (P = 0.03), with less damage observed in Hubbard JA757, as compared to JA787. These findings enhance understanding of how targeted modifications in husbandry practices improve poultry welfare and provide practical guidance for optimizing broiler production systems.

100 项与 Warsaw Agricultural University 相关的药物交易

登录后查看更多信息

100 项与 Warsaw Agricultural University 相关的转化医学

登录后查看更多信息