The goal of this feasibility pilot clinical trial is to determine if sildenafil citrate 50mg orally, up to three times during labor, can: 1) reduce perinatal mortality and/or bag and mask ventilation at birth in planned vaginal delivery and 2) reduce the incidence of operative delivery (instrumental vaginal birth or emergency cesarean section) for presumed or suspected fetal distress in up to four facilities of different levels of care in low-resource countries.
The main questions it aims to answer are:
Does sildenafil citrate decrease:
1. the incidence of operative delivery (instrumental vaginal birth or emergency cesarean section) for presumed or suspected fetal distress?
2. the incidence of bag and mask ventilation?
3. the incidence of perinatal mortality?
Researchers will compare sildenafil citrate to a placebo (a look-alike substance that contains no drug) to see if sildenafil works to prevent fetal distress necessitating operative delivery, bag and mask resuscitation at birth, and ultimately, perinatal mortality.
Participants will:
1. Take Sildenafil 50 mg or placebo orally every eight hours during labor (up to 3 doses)
2. Have the (mothers and babies) medical charts reviewed for outcomes, including fetal distress, operative delivery, maternal side effects, neonatal bag & mask ventilation, Apgar Scores, and seizures.
3. Have a neonatal neurological assessment prior to discharge
4. Receive telephone call assessments for re-hospitalization or mortality 7 days post delivery
The results of this feasibility pilot trial will be used to inform the design and conduct of a large pragmatic randomized controlled trial to determine if sildenafil citrate, compared to placebo, will decrease fetal distress and perinatal asphyxia.

开始日期2025-05-01

申办/合作机构

The University of Alabama at Birmingham

[+6]

NCT05558176

/ Unknown status临床4期IIT

Intrapartum Sildenafil Citrate to Prevent Non Reassuring Foetal Status Among Parturients Delivering at LAUTECH Teaching Hospital, Ogbomoso, a Randomised Controlled Trial

Background: Intrapartum non-reassuring foetal status is a global challenge. It is a key contributor to operative deliveries. In low- and middle-income countries, it is a major cause of perinatal deaths, hypoxic ischemic encephalopathy, and cerebral palsy. Through its vasodilatory action and by improving uteroplacental perfusion, intrapartum sildenafil citrate could reduce the risk of intrapartum foetal compromise.
Aim: To determine the effect of intrapartum Sildenafil citrate on the prevention of non-reassuring foetal status among parturients delivering at term.
Specific Objectives: 1. To determine the frequency of non reassuring foetal heart rate (FHR) pattern among parturients delivering at term following administration of intrapartum Sildenafil citrate compared with placebo 2. To determine the rate of Caesarean delivery for non-reassuring FHR following the administration of intrapartum Sildenafil citrate compared with placebo. 3. To determine the rate of instrumental delivery for non-reassuring FHR following the administration of intrapartum Sildenafil citrate compared with placebo 4. To determine the effect of Sildenafil citrate on uteroplacental blood flow compared with placebo. 5. To determine if Sildenafil citrate is associated with an improved APGAR score at 5th minute compared with placebo.
Methodology: Study Design: Double blind randomised controlled trial. Women at term in early labour or undergoing scheduled induction of labour will be randomly allocated to receive 50 mg of sildenafil citrate or placebo orally once admitted in labour 6 hourly up to a maximum dose of 150 mg. Intrapartum foetal monitoring will be done by continuous cardiotocogragh, labour will be monitored with the aid of partograph following the departmental protocol for conduct of labour.
Planned Handling of Results: Obtained data will be analyzed using IBM (International Business Machines Corporation) SPSS (Statistical Product and Service Solutions) version 21, taking level of significance as p-value <0.05. Categorical variables will be expressed as percentages and presented using frequency tables and charts. The chi-square test will be used to test for association between categorical variables. Continuous variables will be presented as mean or median. Differences between continuous variables will be compared with the Student t test.

开始日期2022-04-08

申办/合作机构

Ladoke Akintola University of Technology

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项与 Ladoke Akintola University of Technology 相关的文献（医药）

2025-12-31·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Diamondoid geochemistry of Niger Delta source rocks: implication for petroleum exploration

作者: Xiong, Yongqiang Q. ; Li, Yun ; Adedosu, T.A. ; Akinlua, Akinsehinwa ; Adekola, Solomon A. ; Ibeachusim, Blessing I.

Investigation on the use of diamondoids to assess the extent of thermal maturity, depositional environment, and origin of Niger Delta source rocks was carried out.This was done to evaluate the significant of diamondoids in petroleum exploration in the basin.Pulverized rock samples selected from four Niger Delta oil wells, were extracted with Soxhlet extraction technique.The biomarkers content of saturated hydrocarbons fraction was assayed by gas chromatog.-mass spectrometry (GC-MS) while the diamondoids content was analyzed using GC-MS-MS.The distribution of saturated hydrocarbons; n-alkanes, pristane, pyhtane, steranes, and terpanes revealed that samples from well AW were sourced from mixed terrestrial/marine organic matter while samples from wells OP, GB, and OT were sourced largely from terrestrial organic matter origin.The Pr/Ph ratio values indicated that the organic matter of wells AW and OP samples were deposited under suboxic conditions while those of wells GB and OT were deposited under anoxic conditions.Hopane and sterane thermal maturity geochem. parameters showed that the organic matter in source rocks from the four wells are thermally mature.Diamondoids source parameters indicated that well AW source rock samples had mixed marine/terrestrial organic matter input, while samples from wells OP, GB, OT were sourced from terrestrial organic matter, which is in perfect agreement with the results of other source geochem. parameters, thus indicating that diamondoids are good tools in determining the origin of petroleum.Diamondoid maturity parameters showed that all the samples from the four wells are thermally mature with maturity level ranging from early to main oil window.This study revealed that diamondoids can be used to evaluate petroleum occurrence in the study area or any other sedimentary basins.

2025-12-31·Annals of Medicine

Prevalence, pattern, and predictors of WPV against medical interns in Southwest Nigeria: a cross-sectional study

Article

作者: Olatunji, Samuel ; Olaniyi, Peter ; Afolabi, Samson ; Ajagbe, Kamil ; Ojo, Deborah ; Olatunji, Gbolahan ; Toritseju, Tsele ; Awodun, Adedamola ; Olamide, Kadiri A. ; Aderinto, Nicholas ; Jegede, Oluwatosin Samson ; Yusuf, Ismaila Ajayi ; Ijitade, Grace

BACKGROUNDWorkplace violence (WPV) is a significant occupational hazard threatening the safety and well-being of medical interns in Nigeria. Despite its critical impact, there is a notable research gap regarding the prevalence, patterns, and influencing factors of WPV among medical interns in Southwest Nigeria. This study aims to fill this gap by investigating these aspects.METHODSThis cross-sectional study utilized online questionnaires to collect data from 379 medical interns at ten hospitals in Southwest Nigeria. The data were analyzed using descriptive statistics and logistic regression.RESULTSThe study found that 62.5% of medical interns had experienced WPV. Verbal abuse was the most common type of violence (63.3%), followed by threats (50.4%), physical assault (24.3%), verbal sexual harassment (13.2%), and physical sexual abuse (2.6%). The primary perpetrators were patients' relatives (81.9%) and patients (61.2%). WPV predominantly occurred in the afternoon (68.8%) and in emergency rooms (70.5%). The primary triggers were long waiting times (64.6%) and unmet patient needs (54.9%). Female interns had higher odds of experiencing WPV, with an adjusted odds ratio of 3.01 (95% CI: 0.82-11.03, p = 0.01) than their male counterparts.CONCLUSIONWPV is prevalent among medical interns in Southwest Nigeria, with patients as the main perpetrators. Healthcare organizations must implement measures such as promoting a culture of respect, establishing zero-tolerance policies, training interns to recognize and address WPV, and providing support for victims.

2025-08-01·Advances in Colloid and Interface Science

Porous MIL, ZIF, and UiO metal-organic frameworks for adsorption of pharmaceuticals and personal care products

Review

作者: Adegoke, Kayode Adesina ; Okeke, Emmanuel Sunday ; Amaku, James F ; Akpotu, Samson O ; Ohoro, Chinemerem Ruth ; Omotola, Elizabeth Oyinkansola ; Akpomie, Kovo G ; Malloum, Alhadji ; Olisah, Chijioke ; Conradie, Jeanet

Pharmaceuticals and personal care products (PPCPs) are a newly identified category of emerging global pollutants often found in aquatic systems. Efficient removal of these pollutants from the water/wastewater is currently problematic because of their low biodegradability and high hydrophilicity, as well as their distinct physicochemical features and lower concentrations. Materials of Institut Lavoisier (MIL), Zeolitic imidazolate framework (ZIF), and University of Oslo (UiO) are highly engineered metal-organic frameworks (MOFs) composed of unique components necessary for the formation of crystals with exceptional porosity, large surface areas, large pore sizes, crystalline structures, tunable properties, excellent chemical and thermal stability for environmental remediation. This study provides detailed and combined applications of UiOs, MILs, and ZIFs as adsorbents for capturing the new class of emerging pollutants (PPCPs) from the liquid phase. MOFs as ideal candidates for PPCP decontamination were discussed, followed by the MOF porosity and factors that affect MOF stability. Various synthetic approaches for MILs, ZIFs, and UiOs were discussed, as well as their corresponding pros and cons. An in-depth performance of these three MOFs for adsorptive removal of PPCPs from the liquid phase was discussed, assessing the state-of-the-art for specific applications and the effectiveness of UiOs, MILs, and ZIFs as adsorbents for PPCP decontamination . The unique performance garnered from the study provided a way forward/potential for real-life/practical applications of these sorbents and insight into corresponding mechanisms and synergistic relationships. To foster the advancement of the field, viable shortcomings and strengths associated with these novel classes of MOFs, treatment options, and knowledge gaps to explore specific research directives for large-scale or industrial-scale applications were highlighted.

项与 Ladoke Akintola University of Technology 相关的新闻（医药）

2023-12-14

·PRNewswire

The Inner Circle Acknowledges, Wale Charles Abolarin as a Distinguished Healthcare Professional for his contributions to the field of Clinical Informatics Technology

OWINGS MILLS, Md., Dec. 14, 2023 /PRNewswire/ -- Prominently featured in The Inner Circle, Wale Charles Abolarin is acknowledged as a Distinguished Healthcare Professional for his contributions to the field of Clinical Informatics Technology. Dr. Abolarin received his Doctorate of Medicine specializing in Anesthesiology from the Ladoke Akintola University of Technology in 2009. He furthered his education in the United States at the University of South Florida, obtaining a graduate certificate in Health Informatics in 2016 and a Master's degree in Health informatics in 2017. In addition, Dr. Abolarin boasts an impressive array of prestigious certifications in Leadership and Health Information Technology, among them the notable Physician IT Architect Certificate. Touting more than 14 years in the Healthcare, Dr. Abolarin stands at the forefront as the CEO and Chief Medical Informatics Officer of Helix Healthcare Inc. This esteemed institution is not just a provider but a beacon of hope for those with developmental disabilities in Maryland and beyond. Championing the cause of local communities, Dr. Abolarin passionately avers that the mission of Helix Healthcare goes beyond medical care. It's about sculpting an ecosystem where patients and their families can effortlessly avail themselves of equitable healthcare, find promising employment opportunities, access top-notch job training, community development, and harness the power of education through technology. Helix Healthcare is a lifeline, providing indispensable services like Alternative living units and remote support services. Before stepping into his current role, Dr. Abolarin accumulated an expansive range of experiences across various capacities in the medical field. He has held esteemed roles such as Physician Champion, Physician Executive, Physician Advisor, and Physician Informatics Architect. His association with significant institutions includes the McLaren Health Care Corporation, Atos Digital Health Solutions, Midland Memorial Hospital, Texas Scottish Rite Hospital for Children, Our Lady of Lourdes's Memorial Hospital, MedStar Good Samaritan Hospital, and a number of hospitals in Nigeria. Beyond these roles, Dr. Abolarin has provided consultation services to several US hospitals, pioneering multiple informatics projects. These projects, powered by technology, have been meticulously designed to mitigate physician burnout and amplify productivity. In his relentless pursuit of excellence, he is a member of the American College of Healthcare Executives, the American Society of Anesthesiology, and the Nigerian Medical Association. With an unwavering and formidable passion for serving others, Dr. Abolarin has not only achieved immense success but has also set himself apart in the realm of informatics. One of his crowning achievements is his role as the architect behind the sepsis advisor at McLaren Health Care Corporation, an algorithmic powerhouse designed to swiftly diagnose sepsis, thus acting as a bulwark against potential fatalities. As we gaze into the horizon, let it be known that Dr. Abolarin's legacy as a leader isn't just rooted in his unmatched expertise in healthcare or informatics alone. It's his unparalleled versatility and prowess across diverse fields, from healthcare to entrepreneurship, that truly sets him apart from the crowd. Contact: Katherine Green 516-825-5634 [email protected] SOURCE The Inner Circle

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